A5082129877- Glioma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Advanced Breast Cancer Therapies
- Ferroptosis and cancer prognosis
- Neurofibromatosis and Schwannoma Cases
- Single-cell and spatial transcriptomics
- Mitochondrial Function and Pathology
- Bone Tumor Diagnosis and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Meningioma and schwannoma management
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Chromatin Remodeling and Cancer
- Neuroendocrine Tumor Research Advances
- Pituitary Gland Disorders and Treatments
- RNA modifications and cancer
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Oncology and Treatments
- Cancer Cells and Metastasis
- Renal and related cancers
Vanderbilt University Medical Center
2016-2025
Vanderbilt University
2012-2024
University Medical Center
2024
University Hospital and Clinics
2024
Vanderbilt-Ingram Cancer Center
2020-2023
Bipar
2015-2023
Breast Cancer Research Foundation
2022-2023
Neurological Surgery
2015-2019
The Ohio State University
2016
Indiana University – Purdue University Indianapolis
2016
Amplification and activating mutations of the epidermal growth factor receptor (EGFR) oncogene are molecular hallmarks glioblastomas. We hypothesized that deletion NFKBIA (encoding nuclear κ-light polypeptide gene enhancer in B-cells inhibitor-α), an inhibitor EGFR-signaling pathway, promotes tumorigenesis glioblastomas do not have alterations EGFR.We analyzed 790 human for deletions, mutations, or expression EGFR. studied tumor-suppressor activity tumor-cell culture. compared results with...
Chordoma and chondrosarcoma of the skull base are rare tumors with overlapping presentations anatomic imaging features but different prognoses. We hypothesized that these might be distinguished by using diffusion-weighted MR imaging.We retrospectively reviewed 19 patients pathologically confirmed chordoma or who underwent both conventional imaging. Differences in distributions ADC were assessed Kruskal-Wallis test. Associations between histopathologic diagnosis (T2 signal intensity, contrast...
We hypothesized that the apparent diffusion coefficient (ADC) and other MRI features can be used to predict medulloblastoma histologic subtypes, as defined by World Health Organization (WHO) in WHO Classification of Tumours Central Nervous System.A retrospective review pediatric patients with between 1989 2011 identified 38 both pretreatment original pathology slides. The mean minimum tumor ADC values conventional were compared among subtypes.The cohort included following subtypes: 24...
Mass cytometry measures 36 or more markers per cell and is an appealing platform for comprehensive phenotyping of cells in human tissue tumor biopsies. While disaggregation fluorescence protocols were pioneered decades ago, it not known whether established will be effective mass maintain cancer stromal diversity.Tissue preparation techniques systematically compared gliomas melanomas, patient derived xenografts small lung cancer, tonsil as a control. Enzymes assessed included DNase, HyQTase,...
HER2+ breast cancer patients are presented with either synchronous (S-BM), latent (Lat), or metachronous (M-BM) brain metastases. However, the basis for disparate metastatic fitness among disseminated tumor cells of similar oncotype within a distal organ remains unknown. Here, employing models, we show that metabolic diversity and plasticity brain-tropic determine fitness. Lactate secreted by aggressive lactate supplementation to mice bearing Lat limits innate immunosurveillance triggers...
This article shows how mitochondria in murine cardiac changes, importantly elucidating age-related changes. It also is the first to show that MICOS complex may play a role outer membrane mitochondrial structure.
Abstract During aging, muscle gradually undergoes sarcopenia, the loss of function associated with mass, strength, endurance, and oxidative capacity. However, 3D structural alterations mitochondria aging in skeletal cardiac tissues are not well described. Although mitochondrial is decreased capacity, genes responsible for morphological changes during poorly characterized. We measured morphology aged murine gastrocnemius, soleus, using serial block‐face scanning electron microscopy...
Abstract Background Central nervous system (CNS) cancer is the 10th leading cause of cancer-associated deaths for adults, but in pediatric patients and young adults. The variety complexity histologic subtypes can lead to diagnostic errors. DNA methylation an epigenetic modification that provides a tumor type-specific signature be used diagnosis. Methods We performed prospective study using analysis as primary method 1921 brain tumors. All tumors received pathology diagnosis profiling by...
Abstract Therapy resistance and metastatic progression are primary causes of cancer-related mortality. Disseminated tumor cells possess adaptive traits that enable them to reprogram their metabolism, maintain stemness, resist cell death, facilitating persistence drive recurrence. The survival disseminated also depends on ability modulate replication stress in response therapy while colonizing inhospitable microenvironments. In this study, we discovered the nuclear translocation AXL, a TAM...
Persistent neutrophilic meningitis presents a diagnostic challenge, because the differential diagnosis is broad and includes atypical infectious causes. We describe case of persistent due to Aspergillus fumigatus in an immunocompetent man who had no evidence sinopulmonary or cutaneous disease. An epidural glucocorticoid injection was identified as potential route entry for this organism into central nervous system, reported state health department.
Metabolic complications such as obesity, hyperglycemia, and type 2 diabetes are associated with poor outcomes in patients glioblastoma. To control peritumoral edema, use of chronic high-dose steroids glioblastoma is common, which can result de novo diabetic symptoms. These metabolic may affect tumors via profound mechanisms, including activation insulin receptor (InsR) the related insulin-like growth factor 1 (IGF1R) malignant cells. In present study, we assessed expression InsR surgical...
Background: Mass cytometry measures 36 or more markers per cell and is an appealing platform for comprehensive phenotyping of cells in human tissue tumor biopsies. While disaggregation fluorescence protocols were pioneered decades ago, it not known whether established will be effective mass maintain cancer stromal diversity. Methods: Tissue preparation techniques systematically compared gliomas melanomas, patient derived xenografts small lung cancer, tonsil as a control. Enzymes assessed...
Astroblastoma (AB) is a rare CNS tumor demonstrating abundant astroblastomatous pseudorosettes. Its molecular features have not been comprehensively studied and its status as entity controversial. We analyzed cohort of 27 histologically-defined ABs using DNA methylation profiling, copy number analysis, FISH site-directed sequencing. Most cases demonstrated mutually exclusive MN1 rearrangements (n = 10) or BRAFV600E mutations 7). Two additional harbored RELA rearrangements. Other lacked these...
Abstract Purpose: Aberrant activation of EGFR is a hallmark glioblastoma. However, inhibitors exhibit at best modest efficacy in This sharp contrast with the observations EGFR-mutant lung cancer. We examined whether functionally redundant receptor tyrosine kinases (RTKs) conferred resistance to Experimental Design: collected panel patient-derived glioblastoma xenograft (PDX) lines that maintained expression wild-type or mutant serial xenotransplantation and tissue cultures. Using this...
Abstract BACKGROUND Ventricular entry during glioblastoma resection and tumor contact with the subventricular zone (SVZ) have both been shown to associate development of hydrocephalus, leptomeningeal dissemination, distant parenchymal recurrence, decreased survival. However, prior studies did not analyze these variables together in a single-patient population; therefore, it is unknown which an independent predictor outcomes. OBJECTIVE To conduct comparative outcome analysis surgical...
This study demonstrates the potential utility of BET and MEK inhibitors for advanced MYCN-expressing triple-negative breast cancer.
Phospholipase D3 (PLD3) is a protein of unclear function that structurally resembles other members the phospholipase D superfamily. A coding variant in this gene confers increased risk for development Alzheimer’s disease (AD), although magnitude effect has been controversial. Because potential significance obscure protein, we undertook study to observe its distribution normal human brain and AD-affected brain, determine whether PLD3 relevant memory cognition sporadic AD, evaluate molecular...