A5002657145- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- Hepatitis B Virus Studies
- Protease and Inhibitor Mechanisms
- Bioinformatics and Genomic Networks
- Low-power high-performance VLSI design
- Light effects on plants
- Electromagnetic Compatibility and Noise Suppression
- Computational Drug Discovery Methods
- VLSI and FPGA Design Techniques
- Gene expression and cancer classification
- Hepatitis C virus research
- Plant Molecular Biology Research
- Trace Elements in Health
- Liver Disease Diagnosis and Treatment
- Cell Adhesion Molecules Research
- 3D IC and TSV technologies
- Adipose Tissue and Metabolism
- Fish Biology and Ecology Studies
- Diet and metabolism studies
- Protein Interaction Studies and Fluorescence Analysis
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Genetics, Aging, and Longevity in Model Organisms
- Environmental, Ecological, and Cultural Studies
Ben-Gurion University of the Negev
2018-2024
National Institute of Diabetes and Digestive and Kidney Diseases
2023-2024
Adama (Israel)
2024
University of Dhaka
2021-2024
National Institutes of Health
2023
Oregon State University
2023
North Bengal Agricultural University
2022
National Institute of Technology Durgapur
2015-2022
Govind Ballabh Pant University of Agriculture and Technology
2022
Life Sciences Research Foundation
2022
Abstract During aging, muscle gradually undergoes sarcopenia, the loss of function associated with mass, strength, endurance, and oxidative capacity. However, 3D structural alterations mitochondria aging in skeletal cardiac tissues are not well described. Although mitochondrial is decreased capacity, genes responsible for morphological changes during poorly characterized. We measured morphology aged murine gastrocnemius, soleus, using serial block‐face scanning electron microscopy...
Summary Arabidopsis MYC 2 bHLH transcription factor plays a negative regulatory role in blue light (BL)‐mediated seedling development. HY 5 bZIP protein works as positive regulator of multiple wavelengths and promotes photomorphogenesis. Both 5, belonging to two different classes factors, are the integrators signaling pathways. However, functional interrelations these factors development remain unknown. Additionally, whereas 5‐mediated regulation gene expression has been investigated detail,...
Arabidopsis (Arabidopsis thaliana) Short Hypocotyl in White Light1 (SHW1) encodes a Ser-Arg-Asp-rich protein that acts as negative regulator of photomorphogenesis. SHW1 and Constitutive Photomorphogenic1 (COP1) genetically interact an additive manner to suppress Elongated Hypocotyl5 (HY5) is photomorphogenesis promoting basic leucine zipper transcription factor degraded by COP1 ubiquitin ligase the darkness. Here, we report functional interrelation with HY5 seedling development. The vitro...
Acquired resistance to the estrogen receptor (ER) antagonist tamoxifen, is a major obstacle in treatment of breast cancer. Changes Zn
Integrative analysis of multi-level pharmacogenomic data for modeling dependencies across various biological domains is crucial developing genomic-testing based treatments. Chain graphs characterize conditional dependence structures such where variables are naturally partitioned into multiple ordered layers, consisting both directed and undirected edges. Existing literature mostly focus on Gaussian chain graphs, which ill-suited non-normal distributions with heavy-tailed marginals,...
Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disorder caused by expression of mutant DMPK transcripts containing expanded CUG repeats. Pathogenic RNA sequesters the muscleblind-like (MBNL) proteins, causing alterations metabolism. Cardiac dysfunction represents second most common cause death in DM1 patients. However, contribution MBNL titration cardiac unclear. We overexpressed Muscleblind (Mbl), Drosophila orthologue, cardiomyocytes model flies and observed rescue heart...
To study the relevance of preoperative OCT predictors in large macular holes (MH) treated using inverted ILM peel technique.Prospective 95 patients undergoing vitrectomy for MH between January 2019 and December 2020 was performed by dividing into groups depending on various quantitative parameters indices such as base diameter (BD), hole form factor (HFF), index (MHI), (DHI), tractional (THI) minimal diameter, height, nasal temporal arm lengths. Depending upon duration symptoms, were divided...
ABSTRACT Background During aging, muscle gradually undergoes loss of function including sarcopenia, losing mass, strength, endurance, and oxidative capacity. While mitochondrial aging is associated with decreased capacity, the genes morphological changes in mitochondria during still require further elucidation. Furthermore, it not completely understood how 3D structures are altered skeletal cardiac tissues. Methods We measured morphology complexity murine gastrocnemius, soleus, tissues using...
Labeo rohita, commonly known as rui/rohu possesses an important role in agricultural and economic aspects Bangladesh. This study aimed to characterize the mitochondrial genome of this economically fish species. Primers (24 pairs) were designed amplify whole most regions contained 700 800bp. In study, nucleotide sequences 16,607 bp L. rohita determined for first time from Bangladesh, which consists 13 protein-coding genes, 22 tRNA 2 rRNA genes one D-loop region. All similar size compared...
<title>Abstract</title> <bold>Purpose:</bold> Matrix metalloproteinase 9 (MMP-9) has been shown to induce glioblastoma and brain metastases (BM) development spread. However, its clinical significance for monitoring disease progression yet be established. This study evaluates intra-tumoral sera MMP-9 levels their influence on BM patients' overall survival (OS). <bold>Methods: </bold>92 tumor pre-operative samples were obtained from the bank of neurosurgery department at Soroka University...
<title>Abstract</title> <bold>Purpose:</bold> Matrix metalloproteinase 9 (MMP-9) has been shown to induce glioblastoma invasion and brain metastases (BM) spread. However, its clinical significance for monitoring disease progression yet be established. This study evaluates intra-tumoral sera MMP-9 levels their correlation BM patients' overall survival (OS). <bold>Methods: </bold>69 tumor pre-operative samples were obtained from the bank of neurosurgery department at Soroka University Medical...
Abstract Background & Aims Direct‐acting antiviral (DAA) therapy has revolutionized treatment for the hepatitis C virus (HCV). While DAA is common, little known about intrahepatic immunological changes after sustained virologic response (SVR). We aim to describe transcriptional alterations of gut microbiome and liver SVR. Methods Twenty‐two HCV patients were evaluated before 9 months 12 weeks sofosbuvir/velpatasvir treatment. All achieved A biopsy, portal blood (direct vein cannulation),...