Mason Killion
A5092712256- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Mentoring and Academic Development
- Career Development and Diversity
- Genetics, Aging, and Longevity in Model Organisms
- Diversity and Career in Medicine
- Medical Imaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Cardiovascular Function and Risk Factors
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Grit, Self-Efficacy, and Motivation
- Endoplasmic Reticulum Stress and Disease
- Metabolism and Genetic Disorders
- ATP Synthase and ATPases Research
Vanderbilt University
2023-2024
Abstract During aging, muscle gradually undergoes sarcopenia, the loss of function associated with mass, strength, endurance, and oxidative capacity. However, 3D structural alterations mitochondria aging in skeletal cardiac tissues are not well described. Although mitochondrial is decreased capacity, genes responsible for morphological changes during poorly characterized. We measured morphology aged murine gastrocnemius, soleus, using serial block‐face scanning electron microscopy...
Abstract Mitochondria are required for energy production and even give brown adipose tissue (BAT) its characteristic color due to their high iron content abundance. The physiological function bioenergetic capacity of mitochondria connected the structure, folding, organization inner‐membrane cristae. During aging process, mitochondrial dysfunction is observed, regulatory balance dynamics often disrupted, leading increased fragmentation in cells. Therefore, it hypothesized that significant...
Maximizing Access to Research Careers (MARC) programs are aimed increase diversity in science, technology, engineering, math, and medicine (STEMM) fields. However, limited eligibility requirements limit the students who may apply similar programs. At Winston-Salem State University, we piloted a series of workshops, collectively termed
Underrepresented faculty have higher burnout rates and lower grant attainment when compared with their non-minority counterparts. Many in science, technology, engineering, mathematics, medicine (STEMM) disciplines, including underrepresented individuals, often difficulty dedicating time to the writing process, trainees being relegated laboratory tasks training years, resulting a lack of practice academic writing. Notably, past studies shown that individuals are than majority Here, we sought...
Abstract The sorting and assembly machinery (SAM) Complex is responsible for assembling β‐barrel proteins in the mitochondrial membrane. Comprising three subunits, Sam35, Sam37, Sam50, SAM complex connects inner outer membranes by interacting with contact site cristae organizing system complex. particular, stabilizes intermembrane space bridging (MIB) complex, which crucial protein transport, respiratory chain assembly, regulation of integrity. While role Sam50 structure metabolism skeletal...
Mitochondria are hubs of metabolism and signaling play an important role in tumorigenesis, therapeutic resistance, metastasis many cancer types. Various laboratory models demonstrate the extraordinary dynamics mitochondrial structure, but little is known about structure resistance to anticancer therapy. We previously demonstrated importance oxidative phosphorylation survival chemotherapy-refractory triple negative breast (TNBC) cells. As TNBC a highly aggressive subtype with few targeted...
Mitochondria are required for energy production and even give brown adipose tissue (BAT) its characteristic color due to their high iron content abundance. The physiological function bioenergetic capacity of mitochondria connected the structure, folding, organization inner-membrane cristae. During aging process, mitochondrial dysfunction is observed, regulatory balance dynamics often disrupted, leading increased fragmentation in cells. Therefore, we hypothesized that significant...
Abstract This study, utilizing SBF-SEM, reveals structural alterations in mitochondria and myofibrils human heart failure (HF). Mitochondria HF show changes structure, while exhibit increased cross-sectional area branching. Metabolomic lipidomic analyses indicate concomitant dysregulation key pathways. The findings underscore the need for personalized treatments considering individualized HF.
ABSTRACT Background During aging, muscle gradually undergoes loss of function including sarcopenia, losing mass, strength, endurance, and oxidative capacity. While mitochondrial aging is associated with decreased capacity, the genes morphological changes in mitochondria during still require further elucidation. Furthermore, it not completely understood how 3D structures are altered skeletal cardiac tissues. Methods We measured morphology complexity murine gastrocnemius, soleus, tissues using...
Aging The image representing article number 2300186 by Amber Crabtree, Zer Vue, Antentor Hinton Jr., and co-workers depicts 3D reconstruction of folds the inner mitochondrial membrane, known as cristae. team elucidate how cristae spatial organization morphology are altered across aging process in brown adipose tissue.
Abstract The Sorting and Assembly Machinery (SAM) Complex is responsible for assembling β-barrel proteins in the mitochondrial membrane. Comprising three subunits, Sam35, Sam37, Sam50, SAM complex connects inner outer membranes by interacting with contact site cristae organizing system (MICOS) complex. particular, stabilizes intermembrane space bridging (MIB) complex, which crucial protein transport, respiratory chain assembly, regulation of integrity. While role Sam50 structure metabolism...
Cover legend: The cover image is based on the Research Article 3D reconstruction of murine mitochondria reveals changes in structure during aging linked to MICOS complex by Zer Vue et al., https://doi.org/10.1111/acel.14009