A5073614399- RNA Research and Splicing
- Career Development and Diversity
- Mentoring and Academic Development
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Diversity and Career in Medicine
- Prostate Cancer Treatment and Research
- TGF-β signaling in diseases
- Higher Education Research Studies
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- RNA regulation and disease
- Cancer, Lipids, and Metabolism
- Education, Achievement, and Giftedness
- Inflammatory mediators and NSAID effects
- Neurobiology and Insect Physiology Research
- Genetics, Aging, and Longevity in Model Organisms
- Science Education and Pedagogy
- Physiological and biochemical adaptations
- Biomedical and Engineering Education
- Health and Medical Research Impacts
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Genetics, Bioinformatics, and Biomedical Research
University of Southern California
2021-2024
Kaiser Permanente
2020-2024
Emory University
2017-2023
Emory and Henry College
2020-2023
California Institute of Technology
2020
Clark Atlanta University
2012-2017
Center for Cancer Research
2013-2017
Abstract TGF-β plays an important role in the progression of prostate cancer. It exhibits both tumor suppressor and tumor-promoting activities. Correlations between cyclooxygenase (COX)-2 overexpression enhanced production prostaglandin (PG)E2 have been implicated cancer progression; however, there are no studies indicating that effects cells involve PGE2 synthesis. In this study, we investigated regulation COX-1 COX-2 expression whether on cell proliferation migration mediated by PGE2....
Snail transcription factor is up-regulated in several cancers and associated with increased tumor migration invasion via induction of epithelial-to-mesenchymal transition (EMT). MAPK (ERK1/2) signaling regulates cellular processes including cell motility, adhesion, invasion. We investigated the regulation ERK1/2 by breast cancer cells. activity (p-ERK) was higher patient tissue as compared to normal tissue. p-ERK were lines mammary epithelial knockdown MDA-MB-231 T47-D cells decreased or...
Maximizing Access to Research Careers (MARC) programs are aimed increase diversity in science, technology, engineering, math, and medicine (STEMM) fields. However, limited eligibility requirements limit the students who may apply similar programs. At Winston-Salem State University, we piloted a series of workshops, collectively termed
Abstract The success of mentoring derives from active and respectful listening the willingness to learn accept opportunities for personal growth. This shapes every trainee their destined path in science, technology, engineering, mathematics (STEM). act cultivating rapport, asking, pondering meaningful questions, receiving constructive feedback are critical support a productive relationship. Successful STEM can be established allow mentees, especially underrepresented minorities (URMs),...
Abstract Since 1901, the Nobel Prize in Physiology and Medicine has been awarded to numerous individuals for their outstanding contributions. This article presents a comprehensive analysis of recipients, focusing on gender, race, nationality. We observe that an alarming disparity emerges when we examine underrepresentation Black scientists among laureates. Furthermore, trends nationalities show how Americans make up majority winners, while there is noticeable lack gender racial minority...
Working with multiple mentors is a critical way for students to expand their network, gain opportunities, and better prepare future scholastic or professional ventures. However, from underrepresented groups (UR) are less likely be mentored have access mentors, particularly in science, technology, engineering, mathematics (STEM) fields. We developed implemented workshop, provide the necessary foundation prepared establishing mentorships throughout graduate school. Faculty well-versed area of...
Abstract Background The mechanisms that can restore biological activity of mutant p53 are an area high interest given expression is observed in one third prostate cancer. Here we demonstrate Id4, HLH transcriptional regulator and a tumor suppressor, the cancer cells. Methods Id4 was over-expressed cell line DU145 harboring (P223L V274F) silenced LNCaP cells with wild type p53. were used to quantitate apoptosis, localization, DNA binding activity. Immuno-precipitation/-blot studies performed...
Underrepresented faculty have higher burnout rates and lower grant attainment when compared with their non-minority counterparts. Many in science, technology, engineering, mathematics, medicine (STEMM) disciplines, including underrepresented individuals, often difficulty dedicating time to the writing process, trainees being relegated laboratory tasks training years, resulting a lack of practice academic writing. Notably, past studies shown that individuals are than majority Here, we sought...
Identity matters in science, technology, engineering, mathematics, and medicine (STEMM) because it can affect an individual's long-term sense of belonging, which may turn their persistence STEMM. Early K-12 science classes often teach students about the foundational discoveries field, have been predominately made, or at least published, by White men. This homogeneity leave underrepresented individuals STEMM feeling isolated, feel as though they cannot enter fields. study aimed to examine...
The RNA exosome is an evolutionarily-conserved ribonuclease complex critically important for precise processing and/or complete degradation of a variety cellular RNAs. recent discovery that mutations in genes encoding structural subunits cause tissue-specific diseases makes defining the role this within specific tissues important. Mutations component 3 (EXOSC3) gene Pontocerebellar Hypoplasia Type 1b (PCH1b), autosomal recessive neurologic disorder. majority disease-linked are missense alter...
Abstract Despite efforts to increase diversity, a glaring underrepresentation of minorities (URM) persists in the fields science, technology, engineering, and mathematics (STEM). Graduate school can be stressful step STEM pipeline, especially for students previously unaware structure challenges postgraduate education. To promote successful minority participation prepare prospective impending applying attending graduate school, we developed workshop based on mentoring fostering...
Abstract Despite an increase in programming to promote persons excluded by their ethnicity or race (PEER) scholars, minorities remain underrepresented many STEM programs. The academic pipeline is largely leaky for minority (URM) scholars due a lack of effective mentorship. Many URM students experience microaggressions and discrimination from mentors quality mentorship training. In this workshop, we provide framework show trainees what mentoring looks like. Mentees, especially trainees, can...
The Drosophila polyadenosine RNA binding protein Nab2, which is orthologous to a human lost in form of inherited intellectual disability, controls adult locomotion, axon projection, dendritic arborization, and memory through largely undefined set target RNAs. Here, we show specific role for Nab2 regulating splicing ~150 exons/introns the head transcriptome focus on retention male-specific exon sex determination factor Sex-lethal ( Sxl ) that enriched female neurons. Previous studies have...
Experimental evolution with Drosophila melanogaster has been used extensively for decades to study aging and longevity. In recent years, the addition of DNA RNA sequencing this framework allowed researchers leverage statistical power inherent experimental genetic basis longevity itself. Here, we incorporated metabolomic data into generate even deeper insights physiological mechanisms underlying differences in three groups experimentally evolved D. populations different patterns. Our analysis...
Castration‐resistant prostate cancer ( CRPC ) is the emergence of cells that have adapted to androgen‐depleted environment prostate. In recent years, targeting multiple chaperones and co‐chaperones (e.g., Hsp27, FKBP 52) promote androgen receptor AR signaling and/or novel regulatory mechanisms emerged as promising alternative treatments for . We shown inactivation inhibitor differentiation 4 ID 4), a dominant‐negative helix loop protein, promotes de novo steroidogenesis with gene expression...
// Maxwell Korang-Yeboah 1, * , Divya Patel 2, Derrick Morton 2 Pankaj Sharma Yamini Gorantla 1 Jugal Joshi Perri Nagappan Ravi Pallaniappan Jaideep Chaudhary College of Pharmacy, Mercer University, Atlanta, GA, USA Center for Cancer Research and Therapeutic Development, Clark Atlanta These authors have contributed equally to this work Correspondence to: Chaudhary, email: jchaudhary@cau.edu Keywords: ID4, prostate cancer, tumor suppressor, nano-carrier, protein delivery Received: March 11,...
There remains a clear deficiency in recruiting middle school students science, technology, engineering, mathematics, and medicine fields, especially for those entering physiology from underrepresented backgrounds. A large part of this may be arising disconnect between how science is typically practiced at collegiate K-12 level. Here, we have envisioned mitochondria their diverse subcellular structures as an involver students. We present the framework workshop that familiarizes with...