A5068343790- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Epigenetics and DNA Methylation
- Photoreceptor and optogenetics research
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Genetic Syndromes and Imprinting
- Stress Responses and Cortisol
University of Haifa
2019-2024
National Brain Research Centre
2015
Social interactions involve both approach and avoidance toward specific individuals. Currently, the brain regions subserving these behaviors are not fully recognized. The anterior hypothalamic nucleus (AHN) is a poorly defined area, recent studies have yielded contradicting conclusions regarding its behavioral role. Here we explored role of AHN neuronal activity in regulating actions during social interactions. Using electrophysiological recordings from behaving mice, revealed that theta...
Long-term memory of complex olfactory learning is expressed by wide spread enhancement in excitatory and inhibitory synaptic transmission onto piriform cortex pyramidal neurons. A particularly interesting modification inhibition the hyperpolarization reversal potential fast post (fIPSP). Here we study mechanism underlying maintenance such a shift fIPSP. Blocking neuronal specific K+-Cl- co-transporter (KCC2) neurons trained rats significantly depolarized averaged fIPSP spontaneous miniature...
Fear conditioning leads to long-term fear memory formation and is a model for studying fear-related psychopathological conditions such as phobias post-traumatic stress disorder. Long-term believed involve alterations of synaptic efficacy mediated by changes in transmission morphology lateral amygdala (LA). Nck1 key neuronal adaptor protein involved the regulation actin cytoskeleton processes be formation. However, role not known. Here we explored Reduction excitatory neurons LA enhanced...
Abstract Training rodents in a particularly difficult olfactory‐discrimination (OD) task results the acquisition of ability to perform well, termed ‘rule learning’. In addition enhanced intrinsic excitability and synaptic excitation piriform cortex pyramidal neurons, rule learning increased inhibition across whole cortical network point where it precisely maintains balance between excitation. The mechanism underlying such precise inhibitory enhancement remains be explored. Here, we use brain...
In this study we explored whether learning leads to enduring changes in inhibitory synaptic transmission lateral amygdala (LA). We revealed that olfactory discrimination (OD) rats led a long-lasting increase postsynaptic GABAA channel-mediated miniature currents (mIPSCs) LA. Olfactory fear conditioning, but not auditory also enhancement GABAA-mediated mIPSCs. Auditory conditioning or OD learning, induced an reduction the frequency current of mIPSC events. found p21-activated kinase (PAK)...
Summary Social interactions are highly complex, involving both approach and avoidance actions towards specific individuals, dependent on the social context. Currently, brain regions subserving these behaviors not fully known. The anterior hypothalamic nucleus (AHN) is a relatively unstudied poorly defined area, known as part of medial defensive system. Recent studies that examined role AHN in various contexts have yielded contradicting results regarding its contribution to approach,...