A5004154669- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neuroblastoma Research and Treatments
- Brain Metastases and Treatment
- Shoulder Injury and Treatment
- Pancreatic and Hepatic Oncology Research
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Single-cell and spatial transcriptomics
- Neuroendocrine Tumor Research Advances
- Cerebrospinal fluid and hydrocephalus
- Neurofibromatosis and Schwannoma Cases
- Parkinson's Disease and Spinal Disorders
- Hip disorders and treatments
- Cancer Genomics and Diagnostics
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Pituitary Gland Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Spinal Dysraphism and Malformations
- Nursing Roles and Practices
- Orthopaedic implants and arthroplasty
- Trauma and Emergency Care Studies
The Ohio State University Wexner Medical Center
2018-2025
Creighton University
2025
University of Minnesota
2025
Northwestern University
2025
American Occupational Therapy Association
2025
American Physical Therapy Association
2025
University of Vermont Medical Center
2019-2024
University of Vermont
2013-2024
RELX Group (Netherlands)
2017-2022
Radiation Oncology Associates
2022
Mild traumatic brain injury (mTBI), or concussion, in children is a rapidly growing public health concern because epidemiologic data indicate marked increase the number of emergency department visits for mTBI over past decade. However, no evidence-based clinical guidelines have been developed to date diagnosing and managing pediatric United States.To provide guideline based on previous systematic review literature obtain assess evidence toward developing recommendations care professionals...
The Orthopaedic Section of the American Physical Therapy Association (APTA) has an ongoing effort to create evidence-based practice guidelines for orthopaedic physical therapy management patients with musculoskeletal impairments described in World Health Organization's International Classification Functioning, Disability, and (ICF). purpose these revised clinical is review recent peer-reviewed literature make recommendations related nonarthritic heel pain.
Over the last decade, numerous concussion evidence-based clinical practice guidelines (CPGs), consensus statements, and guidance documents have been published. These typically focused on diagnosis of medical management individuals post concussion, but provide little specific for physical therapy its associated impairments. Further, many these targeted populations in care contexts. The primary purpose this CPG is to a set recommendations therapist wide spectrum patients who experienced...
Abstract Background Central nervous system (CNS) cancer is the 10th leading cause of cancer-associated deaths for adults, but in pediatric patients and young adults. The variety complexity histologic subtypes can lead to diagnostic errors. DNA methylation an epigenetic modification that provides a tumor type-specific signature be used diagnosis. Methods We performed prospective study using analysis as primary method 1921 brain tumors. All tumors received pathology diagnosis profiling by...
The Orthopaedic Section of the American Physical Therapy Association (APTA) has an ongoing effort to create evidence-based practice guidelines for orthopaedic physical therapy management patients with musculoskeletal impairments described in World Health Organization's International Classification Functioning, Disability, and (ICF). purpose these clinical is describe peer-reviewed literature make recommendations related nonarthritic hip joint pain. J Orthop Sports Phys Ther....
Due to the decreasing prevalence of IDH1 mutations in older patients, 2016 World Health Organization (WHO) classification brain tumors proposed not perform sequencing for isocitrate dehydrogenase (IDH) glioblastoma patients ≥55 years old. We present a cost-effectiveness analysis estimate financial impact these guidelines. From 2010 2015 we performed 1023 IDH tests gliomas, amounting ~$1.09 million direct laboratory test costs. Samples were tested using R132H-specific immunohistochemistry,...
Introduction. Emerging evidence shows positive impact of postprofessional physical therapy education (residency and fellowship) specific to participants; however, outcomes on organizational are largely unknown. The purpose this project was describe the residency fellowship training has financial metrics. A secondary case study trends associated with higher productivity. Review Literature. Previous studies have demonstrated professional behavior generalized operational education. No evaluated...
ThinPrep is often used for endoscopic ultrasound fine-needle aspiration (EUS-FNA) samples but the sensitivity of this method unknown. The objective study was to compare and accuracy versus smear in pancreas lymph node obtained by EUS-FNA.Patients with suspected malignancy or underwent EUS-FNA. On-site rapid assessment all aspirates using performed. After assessment, three additional passes from each site were submitted into liquid medium. Cytopathologists interpreting slides blinded other....
Update 3 of the Consortium to Inform Molecular and Practical Approaches CNS Tumor Taxonomy (cIMPACT-NOW) recognizes amplification epidermal growth factor receptor (EGFR) as one important aberration in diffuse gliomas (World Health Organization [WHO] grade II/III). While these recommendations endorse testing, a cost-effective, clinically relevant testing paradigm is currently lacking. Here, we use real-world clinical data propose financially effective diagnostic test algorithm context new...
A fundamental problem in developmental neuroscience is understanding how extracellular cues link to complex intracellular signaling pathways drive stage-specific decisions. During the formation of mammalian peripheral nervous system, bone morphogenetic proteins (BMPs) promote neuronal differentiation. BMPs also maintain expression early glial genes such as GFAP, while blocking acquisition a mature, myelinating Schwann cell phenotype. We investigated BMP-activated that contribute gene address...
Abstract The repertoire of coronavirus disease 2019 (COVID-19)-mediated adverse health outcomes has continued to expand in infected patients, including the susceptibility developing long-COVID; however, molecular underpinnings at cellular level are poorly defined. In this study, we report that SARS-CoV-2 (severe acute respiratory syndrome 2) infection triggers host cell genome instability by modulating expression molecules DNA repair and mutagenic translesion synthesis. Further, causes...
Neuroblastoma is a childhood cancer caused by the transformation of sympathoadrenal progenitors. By following formation tumors in homozygous TH-<i>MYCN</i> mice, an established mouse model neuroblastoma, we were able to capture transformed cells prior large, vascularized order determine responsiveness neurotrophic factors. We discovered that ciliary factor (CNTF) receptor abundantly expressed tumor from these mice. Furthermore, CNTF - but not nerve growth factor, brain-derived...