A5003642759- Telomeres, Telomerase, and Senescence
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- T-cell and Retrovirus Studies
- Autophagy in Disease and Therapy
- Toxin Mechanisms and Immunotoxins
- CRISPR and Genetic Engineering
- Xenotransplantation and immune response
University of Vermont
2021-2022
BACKGROUND: The therapeutic efficacy of horse antilymphocyte globulins (ALG) or rabbit antithymocyte (ATG), used for both the prevention and treatment allograft rejection has been well documented. However, clinical use these heterologous antibodies can result in production against proteins development serum sickness via circulating immune complexes. METHODS: We studied human IgG, IgM anti-rabbit anti-horse globulins, 240 samples from 111 kidney transplant recipients, whom 89 were treated...
Abstract The repertoire of coronavirus disease 2019 (COVID-19)-mediated adverse health outcomes has continued to expand in infected patients, including the susceptibility developing long-COVID; however, molecular underpinnings at cellular level are poorly defined. In this study, we report that SARS-CoV-2 (severe acute respiratory syndrome 2) infection triggers host cell genome instability by modulating expression molecules DNA repair and mutagenic translesion synthesis. Further, causes...
Abstract The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus responsible for the current COVID-19 pandemic and has now infected more than 200 million people with 4 deaths globally. Recent data suggest that symptoms general malaise may continue long after infection ended in recovered patients, suggesting SARS-CoV-2 profound consequences host cells. Here we report can trigger a DNA damage response (DDR) African green monkey kidney cells (Vero E6). We observed...