A5055267519- Job Satisfaction and Organizational Behavior
- Workplace Spirituality and Leadership
- Single-cell and spatial transcriptomics
- Religion, Spirituality, and Psychology
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Management Theory and Practice
- Creativity in Education and Neuroscience
- Digital Economy and Work Transformation
- COVID-19 Pandemic Impacts
- Cyberloafing and Workplace Behavior
- Lymphoma Diagnosis and Treatment
- AI in Service Interactions
- Work-Family Balance Challenges
- Gender Diversity and Inequality
- Obsessive-Compulsive Spectrum Disorders
- Attention Deficit Hyperactivity Disorder
- Epigenetics and DNA Methylation
- Retirement, Disability, and Employment
- Cultural Differences and Values
- Higher Education and Employability
- Public Relations and Crisis Communication
- Complex Systems and Decision Making
- Organizational Learning and Leadership
- Cancer-related cognitive impairment studies
Center for Cancer Research
2019-2024
Harvard University
2019-2024
Massachusetts General Hospital
2019-2024
Broad Institute
2019-2024
Dana-Farber/Harvard Cancer Center
2023
London School of Economics and Political Science
2019-2022
Harvard University Press
2022
Georgetown University
2018
Yale University
2012
A subset of patients with IDH-mutant glioma respond to inhibitors mutant IDH (IDHi), yet the molecular underpinnings such responses are not understood. Here, we profiled by single-cell or single-nucleus RNA-sequencing three oligodendrogliomas from who derived clinical benefit IDHi. Importantly, tissues were sampled on-drug, four weeks treatment initiation. We further integrate our findings analysis and bulk transcriptomes independent cohorts experimental models. find that IDHi induces a...
Abstract Past research has found that employees who view themselves as overqualified for their jobs tend to hold negative job attitudes and be unwilling go beyond the call of duty. In challenging situations such during COVID‐19 crisis, when having “all hands‐on deck” may important an organization's survival, mitigating tendencies these becomes important. Adopting a sensemaking perspective on crisis management, we examine whether supervisors' self‐sacrificial leadership can mitigate...
While a positive view of calling has been ubiquitous since its introduction into the literature over two decades ago, research remains unsettled about extent to which it contributes various aspects good life: an optimal way living well via worthwhile endeavors. Further, scholars have identified conceptual types calling, marked by internal versus external foci; yet their differential impact on outcomes indicative life, such as eudaimonic and hedonic well-being (characterized experience...
Research on work as a calling has proliferated since its introduction into the organizational behavior literature over two decades ago. Conceptual reviews of have emerged recently, yet this area lacks systematic, quantitative synthesis necessary to benefit future research. Based sample 201 papers, study provides first comprehensive meta-analysis relationship between and most frequently studied constructs in literature. This approach sheds light what we know about calling's relationships with...
Job crafting refers to the myriad ways employees customize their jobs, such as by altering tasks and social interaction at work. Numerous scholars over past 20 years have remarked on overall need better understand role of time in job crafting. However, literature has not considered how think about time, or, relatedly, they use manage it—and why this might matter for To address these unresolved issues, current paper develops a conceptual model individual-level, time-related characteristics...
Abstract While promotive voice is conventionally considered a favourable work behaviour to the organisation, whether engaging in will help employees move up career ladder inconclusive across handful of studies. Drawing on psychological contract perspective, this study aims understand why and when employees' can contribute supervisor‐rated promotability. We propose that engagement strengthen supervisor‐sponsored balanced with thus promotability, these effects be stronger supervisors have...
Abstract IDH-mutant gliomas exhibit variable responses to mutant-IDH inhibitor (IDHi) therapy; yet, the molecular mechanisms underlying these remain poorly understood. Here, we investigate cellular underpinnings of response by leveraging single cell/nuclei RNA-sequencing on-treatment oligodendroglioma tumor samples resected from three patients who benefited clinically treatment. We integrate findings with cell and bulk RNA-seq data independent cohorts experimental models. find that IDHi...
Voice assistants are interactive technologies that supply information and perform tasks in response to voice commands from human users. The past decade has seen a rapid rise the usage of for work. However, implications these workplace outcomes remain poorly understood. In this paper, we examined how instantaneous, gendered influenced managerial perceptions subordinate helping behaviors. We conducted our examination across three studies—a qualitative pilot study, an experimental study lab,...
Management scholarship is rife with accounts of people pivoting from steady jobs and “good” careers into occupations they view as more personally socially significant. However, existing organizational theory cannot explain how make these career pivots. Through a longitudinal qualitative study 69 individuals associated When to Jump, global community for making “jumps” pursue their passions, this paper explores construct “career pivot self-narrative”—an account the unconventional change...
Summary Recent data showed promising signs of objective tumor responses in subsets patients with low grade glioma treated inhibitors mutant IDH (IDHi) (1). However, the molecular and cellular underpinnings such are not known. Here, we profiled 6,039 transcriptomes by single-cell or single-nucleus RNA-sequencing isolated from three IDH-mutant oligodendroglioma clinical response to IDHi. Importantly, tissues were sampled on-drug, four weeks treatment initiation our dataset includes a matched...
Abstract Human diffuse gliomas are incurable malignancies, where cellular state diversity fuels tumor progression and resistance to therapy. Single-cell RNA-sequencing (scRNAseq) studies recently charted the states of two major categories human gliomas, IDH-mutant (IDH-MUT) IDH-wildtype glioblastoma (GBM), showing that malignant cells partly recapitulate neurodevelopmental trajectories. This raises central questions how cell encoded epigenetically whether unidirectional hierarchies or more...
While promotive voice is conventionally considered a favorable work behavior to the organization, whether engaging in will help employees move up career ladder inconclusive across handful of studies. Drawing on psychological contract perspective, this study aims understand why and when employees’ can contribute supervisor-rated employee promotability. We propose that engagement strengthen supervisors’ balanced with increase their rating promotability, these effects be stronger supervisors...