A5020194529- Effects of Radiation Exposure
- Phagocytosis and Immune Regulation
- Pancreatic and Hepatic Oncology Research
- Advanced Breast Cancer Therapies
- Radiation Therapy and Dosimetry
- Spaceflight effects on biology
- Heat shock proteins research
- NF-κB Signaling Pathways
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Genomics, phytochemicals, and oxidative stress
- Glycosylation and Glycoproteins Research
- CAR-T cell therapy research
- 3D Printing in Biomedical Research
- Biochemical effects in animals
- Anesthesia and Neurotoxicity Research
- Neuroendocrine Tumor Research Advances
- Neuroscience and Neural Engineering
- Cancer, Hypoxia, and Metabolism
- Vitamin C and Antioxidants Research
- Ultrasound and Hyperthermia Applications
- Immune cells in cancer
- Cell death mechanisms and regulation
- Neuroblastoma Research and Treatments
- Hepatitis C virus research
The University of Texas Southwestern Medical Center
2023-2025
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2015-2024
Southwestern Medical Center
2023-2024
University Hospital Bonn
2014
Abstract Therapy resistance and metastatic progression are primary causes of cancer-related mortality. Disseminated tumor cells possess adaptive traits that enable them to reprogram their metabolism, maintain stemness, resist cell death, facilitating persistence drive recurrence. The survival disseminated also depends on ability modulate replication stress in response therapy while colonizing inhospitable microenvironments. In this study, we discovered the nuclear translocation AXL, a TAM...
The neuroblastoma cell line SH-SY5Y has been a well-established and very popular in vitro model neuroscience for decades, especially focusing on neurodevelopmental disorders, such as Parkinson's disease. ability of this type to differentiate compared with other models neurobiology makes it one the few suitable without having rely primary culture neuronal cells. Over years, various, partly contradictory, methods cultivation have reported. This study is intended provide comprehensive guide...
<title>Abstract</title> The Axl receptor tyrosine kinase is pivotal for metastatic tumor progression, immune evasion, and regulating inflammation of innate cells. In this study we investigated Axl’s function in immunogenic tumors found that knockout (KO) mice exhibited a significant delay growth. Single-cell RNA sequencing revealed deficiency increases CD8 T cell activity. Tumor growth was dependent on cells BATF3 expression, indicating role dendritic (DC) cross priming activities....
Hypoxia-induced radioresistance reduces the efficacy of radiotherapy for solid malignancies, including non-small cell lung cancer (NSCLC). Cellular hypoxia can confer through cellular and tumor micro-environment adaptations. Until recently, studies evaluating secondary to were designed maintain only before during irradiation, while any handling post-irradiated cells was carried out in standard oxic conditions due unavailability workstations. This limited possibility simulating vivo or...
Nuclear factor kappaB (NF-κB) is a central transcription in the immune system and modulates cell survival response to radiotherapy. Activation of NF-κB was shown be an early step cellular ultraviolet A (UVA) ionizing radiation exposure human cells. activation by genotoxic stress-dependent sub-pathway after different qualities had been evaluated very limited extent. In addition, resulting gene expression profile, which shapes tissue response, unknown. Therefore, this study low- high-linear...
Introduction Exposure to space conditions during crewed long-term exploration missions can cause several health risks for astronauts. Space radiation, isolation and microgravity are major limiting factors. The role of astrocytes in cognitive disturbances by radiation is unknown. Astrocytes' response toward low linear energy transfer (LET) X-rays high-LET carbon ( 12 C) iron 56 Fe) ions was compared reveal possible effects space-relevant radiation. Since astronauts exposed ionizing missions,...
Astronauts are exposed to considerable doses of space radiation during long-term missions. As complete shielding the highly energetic particles is impracticable, cellular response space-relevant qualities has be understood in order develop countermeasures and reduce risk uncertainties. The transcription factor Nuclear Factor κB (NF-κB) plays a fundamental role immune pathogenesis many diseases. We have previously shown that heavy ions with linear energy transfer (LET) 100–300 keV/µm nine...
In the rapidly advancing field of synthetic biology, there exists a critical need for technology to discover targeting moieties therapeutic biologics. Here we present INSPIRE-seq, an approach that utilizes nanobody library and next-generation sequencing identify nanobodies selected complex environments. INSPIRE-seq enables parallel enrichment immune cell-binding penetrate tumor microenvironment. Clone specificity vary across cell subtypes in tumor, lymph node, spleen. identifies dendritic...
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<div>Abstract<p>Therapy resistance and metastatic progression are primary causes of cancer-related mortality. Disseminated tumor cells possess adaptive traits that enable them to reprogram their metabolism, maintain stemness, resist cell death, facilitating persistence drive recurrence. The survival disseminated also depends on ability modulate replication stress in response therapy while colonizing inhospitable microenvironments. In this study, we discovered the nuclear...
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<p>Supplementary Figure 3</p>
<p>Supplementary Figure 2</p>
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<p>Supplementary Figure 3</p>
<p>Supplementary Figure 4</p>
<div>Abstract<p>Therapy resistance and metastatic progression are primary causes of cancer-related mortality. Disseminated tumor cells possess adaptive traits that enable them to reprogram their metabolism, maintain stemness, resist cell death, facilitating persistence drive recurrence. The survival disseminated also depends on ability modulate replication stress in response therapy while colonizing inhospitable microenvironments. In this study, we discovered the nuclear...
<p>Supplementary Figure 1</p>