A5090222521- Sarcoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Bone Tumor Diagnosis and Treatments
- Chromatin Remodeling and Cancer
- Methemoglobinemia and Tumor Lysis Syndrome
- Neonatal Health and Biochemistry
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Blood groups and transfusion
- Ethics and Legal Issues in Pediatric Healthcare
- Testicular diseases and treatments
- Congenital Diaphragmatic Hernia Studies
- Polyomavirus and related diseases
- Tumors and Oncological Cases
- Neurofibromatosis and Schwannoma Cases
- Blood disorders and treatments
- Lymphoma Diagnosis and Treatment
- Cancer survivorship and care
- Musculoskeletal synovial abnormalities and treatments
- Radiation Dose and Imaging
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related Molecular Pathways
- Advances in Oncology and Radiotherapy
- Ovarian cancer diagnosis and treatment
Walter Reed National Military Medical Center
2021-2025
Uniformed Services University of the Health Sciences
2019-2025
Newcastle upon Tyne Hospitals NHS Foundation Trust
2024
Palmetto Hematology Oncology
2021
San Antonio Uniformed Services Health Education Consortium
2015-2020
Brooke Army Medical Center
2016-2020
Pediatrics and Genetics
2020
Massachusetts General Hospital
2016
Children's Hospital Colorado
2012
University of Colorado Denver
2012
There is limited research on cancer incidence in pediatric and adolescent/young adult patients using health care claims data no standard algorithm for such a query. This study aimed to establish an estimate rates multiple types from 2013 2017 within the Military Health System compare them reported National Cancer Institute Surveillance, Epidemiology, End Results (SEER) program. The Data Repository was queried by International Classification of Diseases 9 10 codes look-back-periods identify...
Congenital glioblastoma (GBM) is a rare brain tumor of infancy. While histologically they resemble pediatric and adult GBM, growing evidence suggests distinct molecular profile. We report the case 7-day-old infant female with congenital GBM found to harbor GOPC-ROS1 fusion. She underwent surgical resection, moderate-intensity chemotherapy without radiation, remains disease-free 4 years from completion therapy. frequency this mutation not known, identification oncogenic driver may provide...
Rituximab is an antibody that binds to B-lymphocytes and increasingly used during pregnancy. As immunoglobulin G, it will transfer across the placenta. Previous case reports describe a diversity of clinical presentations in neonates born following rituximab exposure utero. Our first offer long-term experience care infant with severe neutropenia prolonged profound hypogammaglobulinemia class-switching B cell defect after utero exposure.
Malignant giant cell tumor of bone (GCTB) is a rare, aggressive, sarcoma occurring in adolescent and young adults. It characterized by the presence multinucleated cells an aggressive clinical course. Because rarity this tumor, no standard therapies have been identified. Current treatment regimens often include osteosarcoma chemotherapy protocols. We present case malignant GCTB with KRAS G12V mutation. This mutation known oncogenic driver that has not previously reported on patients GCTB.
The RAS/mitogen-activated protein kinase pathway plays a significant role in cell cycle regulation. Germline mutation of this leads to overlapping genetic disorders, RASopathies, and is also an important component tumorigenesis. Here we describe rare case myelodysplastic syndrome with monosomy 7 pediatric patient germline RRAS mutation. mutations have been implicated the development juvenile myelomonocytic leukemia, but our suggests display broader malignant potential. Our supports...
Hyperbilirubinemia in the first 24 hours of life a newborn is pathologic, necessitating additional evaluation. We report case hemolysis and subsequent hyperbilirubinemia an otherwise normal term neonate resulting from oxidative stress form maternal cautopyreiophagia: ingestion burnt matchstick heads. During third trimester pregnancy, infant's mother consumed more than 300 heads weekly for 4 weeks. Matches contain potassium chlorate, powerful oxidant that when ingested can ultimately lead to...
Trends in diagnostic biopsy sample collection approaches for primary bone sarcomas have shifted the past 2 decades. Although open/incisional biopsies used to be predominant approach obtain material Ewing sarcoma and osteosarcoma, image-guided core needle increased frequency are safe patients. These procedures less invasive reduce recovery times but potential limitations. The quantity quality of tissue obtained through these vary between institutions. Acquired viable volumes can low, limiting...
An appropriate-for–gestational age (AGA) African American female infant is born at term via elective, repeat cesarean section 39 weeks' gestation to a gravida 2, para 2 woman. The mother's pregnancy had been complicated only by gestational hypertension, and maternal antenatal testing results were unremarkable. Maternal blood type O positive with negative antibody screen during pregnancy. Meconium fluid noted delivery; however, the vigorous strong cry requires routine resuscitation Apgar...
BACKGROUND: Congenital glioblastomas (cGBM) are uncommon tumors presenting in early infancy (less than six months). Molecular features have not been sufficiently explored due to the rarity of these tumors. We previously reported that cGBM appears similar pediatric and adult GBM based on histology microarray expression analysis but generally has a far more favorable outcome, with good responses subtotal resection followed by moderate intensity chemotherapy (Neuro Oncol 14(7):931–41, July...
Soft tissue myoepithelial carcinoma is a rare tumor first reported in the salivary gland. There considerable heterogeneity between pathology findings, aggressiveness, and response to treatment. Recent molecular testing has identified recurrent genetic changes with PLAG mutations gland primary tumors loss of SMARCB1 EWSR1/FUS gene carcinoma. component switch/sucrose nonfermentable (SWI/SNF) complex, an essential cellular regulator. ARID1A another SWI/SNF complex subunit potent oncogenic...
Introduction: Giant cell tumors of the bone (GCTB) are a historically benign skeletal neoplasm associated with multinucleated osteoclast-type giant cells. The presence cells is not specific to GCTB and diagnostic picture can be clouded by their presence. sarcomas also have background but exhibit increased mitotic activity an overall more aggressive clinical course. We present case primary sarcoma bone, both highlight potential difficulty in diagnosis introduce unique …