A5091408486- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Treatments and Studies
- Chromosomal and Genetic Variations
- Colorectal and Anal Carcinomas
- Appendicitis Diagnosis and Management
- Intraperitoneal and Appendiceal Malignancies
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Plant Disease Resistance and Genetics
- COVID-19 and healthcare impacts
- Thyroid and Parathyroid Surgery
- Wheat and Barley Genetics and Pathology
- Hernia repair and management
- Parathyroid Disorders and Treatments
- Diverticular Disease and Complications
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Ovarian cancer diagnosis and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- Stoma care and complications
- Cancer Diagnosis and Treatment
University of Freiburg
2024
Hospital Universitario Príncipe de Asturias
2015-2024
Universidad de Alcalá
2005-2024
University of Birmingham
2020-2024
National Institute for Health Research
2024
Universidad de Valladolid
2023
Real Academia Española
2023
Universidad de Granada
2023
Association for Cancer Surgery
2021
NIHR Birmingham Biomedical Research Centre
2021
Copper, zinc, magnesium, calcium and iron were measured in serum lung tissue – tumor mass histologically nonneoplastic from cancer patients compared with concentrations healthy subjects control obtained nonmalignant disease. Lung showed a significant increase Cu Cu/Zn ratio levels decrease Zn Fe concentrations. These findings correlated TNM stage of the disease, but not histologic type tumor. Malignant higher level Cu, Ca, Mg, lower than that found samples, as well an Mg regard to samples...
Serum zinc (Zn), copper (Cu), and the Cu/Zn ratio were evaluated in 84 patients with pulmonary lesions before surgery 100 healthy normal controls. There 20 benign 64 malignant lung tumors. Only mean (± SD) was significantly higher tumors (2.24 ± 0.78) than tissue (1.63 033) (P < 0.001). In group, lower (1.43 0.29). Patients advanced disease (Stage III) had Stages I II (2.65 0.86 versus 1.9 0.27) At a cutoff value of 1.72, sensitivity 89%, specificity 84%, positive predictive 78%, negative...
Summary Background Previous studies have reached conflicting conclusions regarding the efficacy of mesalazine in prevention recurrent diverticulitis. Aim To investigate and safety granules recurrence diverticulitis after acute uncomplicated Methods Two phase 3, randomised, placebo‐controlled, double‐blind multicentre trials ( SAG ‐37 ‐51) investigated patients with prior episodes (<6 months) left‐sided Patients were randomised to receive either 3 g once daily or placebo ‐37, n=345) 1.5...
The objective of this study was to evaluate the need for cholecystectomy in patients who underwent surgery gallstone ileus.This a retrospective review clinical history ileus between December 1992 and 2018 follow-up until October 2020. Data regarding surgical intervention, location obstruction, procedure performed were collected, as well complications relation biliary pathology postoperative period.Twenty-five ileus. In all patients, except one, site obstruction identified. mean age 72...
Objectives: The aim of this study was to analyze the prognostic factors survival in patients with peritoneal metastasis (PM) from colorectal cancer (CRC). type relationship between and PM time detection used determine whether it synchronous primary tumor or metachronous. Patients Methods: Retrospective observational study. It included treated for adenocarcinoma diagnosed January 2005 December 2019 who presented at diagnosis during follow-up. Variables, such as sex, age, differentiation...
The prognostic value of p53 and c-erbB-2 immunostaining preoperative serum levels CEA CA125 was investigated in a prospective multicentric study including 465 consecutive non-small cell lung cancer (NSCLC) patients with resectable tumors. Four end-points were used: death, first relapse (either locoregional or metastasis), loco-regional recurrence metastasis development. Standard statistical survival methods (Kaplan-Meier Cox regression) used. specificity the effect across different types...
Introduction: Colorectal cancer is the fourth leading cause of cancer-related death in both men and women our population. In this regard, rectal accounts for more than half colorectal deaths, its incidence expected to increase coming years. There have been significant changes neoadjuvant therapy regimens, with promising results, as demonstrated by recent RAPIDO PRODIGE23 studies. Around 40% patients diagnosed locally advanced show some degree response treatment, complete tumor regression...
Tumor nodules or tumor deposits (TDs) are a histopathological prognostic factor that associated with negative evolutionary course in patients colorectal cancer (CRC). There still controversial aspects of TDs, including how they should be integrated into the TNM classification system. The objective this study was to analyze predictive value TDs for cancer-related survival (CRS) and time-to-recurrence (TTR) evaluate whose tumors also presented lymph node metastasis (LNM). In retrospective...
Osteoporotic vertebral fractures (OVFs) significantly impact morbidity, mortality, functionality, and quality of life. Vertebroplasty, a widely utilized treatment for OVFs, has its efficacy safety debated due to varying outcomes reported across clinical trials meta-analyses. This study aims critically review conduct meta-analysis randomized controlled (RCTs) focusing on the vertebroplasty, specifically association with serious adverse effects development new fractures, while exploring...
The chromosome structure of four different wild populations and a cultivated line Triticum timopheevii (2n = 28, A t GG) relative to turgidum AABB) was studied, using genomic in situ hybridisation (GISH) C-banding analysis meiotic configurations interspecific hybrids. Two accessions the showed standard karyotype. other two are homozygous for translocation 5A /3G translocations 1G/2G 5G/6G. GISH revealed that all T. carry intergenome 6A /1G 1G/4G identified position breakpoint /3G. pairing at...
Serum CA 125 levels were evaluated in 130 healthy subjects and 133 patients with untreated pulmonary lesions. These 33 benign conditions 100 lung cancer. The mean concentration of was higher cancer (37 +/- 81 U/ml) than those nonmalignant disease (4.2 5.7 (P less 0.01). In the control group concentrations significantly lower (0.63 1.5 0.001). this tumor marker related to tumor-node-metastasis (TNM) stage. At a cut-off value 15 U/ml, had sensitivity 44%, specificity 100%, positive predictive...
Chromosome pairing at metaphase I was studied in different interspecific hybrids involving Aegilops speltoides (SS) and polyploid wheats Triticum timopheevii (A t A GG), T. turgidum (AABB), aestivum (AABBDD) to study the relationships between S, G, B genomes. Individual chromosomes their arms were identified by means of C-banding. Pairing G S genomes × Ae. GS) reached a frequency much higher than (ABS) (ABDS) hybrids, B- G-genome (AA BG) or BGD) hybrids. These results support degree...
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have benefits for survival in some cancers with peritoneal metastasis. Hematologic toxicity described rate is 2 to 38%.Patients admitted an intensive care unit (ICU) after CRS HIPEC over 78 months. The data recorded were demographic characteristics, the severity of illness, complete blood samples, type cancer extension, drug temperature, ICU hospital stay mortality, bleeding, need transfusion products.Of 96...
Colorectal cancer (CRC) ranks as the third leading cause of cancer‑related mortality in developed countries. While its incidence early stages has increased due to screening programs, a significant number patients experience development metastases either at time diagnosis or during follow‑ups. Unlike certain other types cancer, such breast, prostate, lung where bone tissue is common site for secondary dissemination, CRC primarily spreads lymph nodes, liver and lungs. The occurrence from rare...
To assess the prognostic value of pretreatment serum neuron-specific enolase (NSE) in nonsmall cell lung cancer (NSCLC), levels were measured 84 NSCLC patients, 40 healthy controls, and 20 patients with benign pulmonary diseases. NSE concentration was higher (11.7 +/- 10.8 ng/ml) (mean SD; median = 9.7 than two control groups (p < 0.001). Serum neither related tumor-node-metastasis (TNM) stage, nor histologic subtype. At a cutoff 15 ng/ml, had sensitivity 27.3% specificity 96%. Patients...
To investigate the relationship between histopathologic effects of preoperative chemoradiotherapy in rectal cancer and proteins, proliferating cell nuclear antigen (PCNA) p53.Samples from 73 tumors were examined. The observed resected specimens induced by correlated with inmunohistochemical expression PCNA p53 biopsies obtained rectoscopy before chemoradiotherapy.Thirty-five showed a high index (48%). Nuclear accumulation protein was detected 53 (72%). Specimens assigned one four grades...