A5079199005- Health and Medical Studies
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Gastrointestinal motility and disorders
- Diabetes Treatment and Management
- Renal Diseases and Glomerulopathies
- Neuropeptides and Animal Physiology
- Health Systems, Economic Evaluations, Quality of Life
- Child and Adolescent Health
- Organ Transplantation Techniques and Outcomes
- Psychiatric care and mental health services
- Social and Educational Sciences
- Cardiac, Anesthesia and Surgical Outcomes
- Atrial Fibrillation Management and Outcomes
- Xenotransplantation and immune response
- Employment and Welfare Studies
- Clinical practice guidelines implementation
- Healthcare Policy and Management
- Diabetes Management and Research
- Pharmacology and Obesity Treatment
- Healthcare Systems and Challenges
- Social and Demographic Issues in Germany
- Workplace Health and Well-being
- Healthcare Systems and Practices
- Hormonal Regulation and Hypertension
Centre of Registers Vastra Gotaland
2016-2024
Region Västra Götaland
2017-2022
University of Gothenburg
1984-2019
Sahlgrenska University Hospital
1990-2014
Skåne University Hospital
2014
Lund University
2014
Karolinska Institutet
2013
Tengion (United States)
2009
University of Skövde
2005
Massachusetts General Hospital
1997
OBJECTIVE--To determine whether inhibition of angiotensin converting enzyme can reduce the rate decline in kidney function more than reducing blood pressure with other antihypertensive treatment. DESIGN--Prospective, open randomised study lasting a mean 2.2 years patients diabetic nephropathy. SETTING--Three outpatient nephrology clinics. PATIENTS--40 insulin dependent diabetes and nephropathy reduced renal function. INTERVENTION--Antihypertensive treatment enalapril or metoprolol, usually...
The effects of angiotensin converting enzyme inhibition with captopril were investigated in patients diabetic nephropathy and hypertension. After nine days9 treatment glomerular filtration rate was unchanged 13 patients, whereas renal plasma flow had increased from 265 to 302 ml/min/1.73 m2 body surface area (p less than 0.05) the fraction decreased 14.3 12.8% 0.025). During two years9 14 mean arterial blood pressure fallen by 5 mm Hg 0.005) deterioration 10.3 2.4 ml/min/year 0.005). There...
Atrial fibrillation (AF) is a major risk factor for ischemic stroke. This study aims to update the knowledge about AF and associated stroke benefits of anticoagulation.We extracted data from hospital, specialized outpatient, primary healthcare drug registries in Swedish region with 1.56 million residents. We identified all individuals who had received an diagnosis during previous 5 years; events 2010; patients aged ≥50 years warfarin 2009.AF been diagnosed 38 446 subjects were alive at...
Background The long-term impact of new-onset postoperative atrial fibrillation (POAF) after coronary artery bypass grafting and the benefit early-initiated oral anticoagulation (OAC) in patients with POAF are uncertain. Methods Results All who underwent without preoperative Sweden from 2007 to 2015 were included a population-based study using data 4 national registries: SWEDEHEART (Swedish Web System for Enhancement Development Evidence-based Care Heart Disease Evaluated According...
<h3>Introduction</h3> Vertebrobasilar dissecting aneurysms (VBDAs) are associated with serious complications and a poor prognosis. It is believed that inflammation of the aneurysm wall may be main cause rupture or deterioration. Atorvastatin has been shown to inhibit suitable drug candidate. Here, we report clinical research study protocol investigate whether atorvastatin inhibits wall, as measured by signal index enhancement. <h3>Methods analysis</h3> We have designed single-centre,...
<b>Objectives</b> To compare the risk associated with systolic blood pressure that meets current recommendations (that is, below 140 mm Hg) lower levels in patients who have type 2 diabetes and no previous cardiovascular disease. <b>Design</b> Population based cohort study nationwide clinical registries, 2006-12. The mean follow-up was 5.0 years. <b>Setting</b> 861 Swedish primary care units hospital outpatient clinics. <b>Participants</b> 187 106 registered national...
OBJECTIVE We examined detailed renal and cardiovascular (CV) outcomes after gastric bypass (GBP) surgery in people with obesity type 2 diabetes mellitus (T2DM), across several function categories, a nationwide cohort study. RESEARCH DESIGN AND METHODS linked data from the National Diabetes Register Scandinavian Obesity Surgery four national databases holding information on socioeconomic variables, medications, hospitalizations, causes of death matched 5,321 individuals T2DM who had undergone...
In response to the Covid-19 pandemic, we designed and initiated a nationwide linked multi-register, regularly updated, observational study for timely urgent scientific questions.
During 1988 and 1989 > 500 cases of serious group A streptococcal infections were reported in Sweden, many with a fatal outcome. We report here on 11 consecutive patients septic preshock/shock multiorgan failure, including acute renal failure. 10 had verified streptococci (GAS) serotype T1M1 while 1 patient was culture negative but clinical signs severe infection serological evidence GAS infection. Presenting symptoms high fever, relative bradycardia, edema In all the condition deteriorated...
Conventional meshes for hernia repair and abdominal wall reinforcement are usually made from polypropylene, polyester or other synthetic plastic materials known to promote foreign body reactions a state of chronic inflammation that may lead long-term complications. A novel approach is use resorbable implants like TIGR® Matrix Surgical Mesh. Preclinical studies have shown this mesh maintains mechanical integrity beyond the point in time where newly formed tissue capable carrying loads. This...
AbstractRectal biopsy specimens from patients with ulcerative proctitis/proctosigmoiditis (UP/PS) were investigated immunocytochemically. In general, a changed mucosal innervation was demonstrated, marked increase in the number of nerve fibres and terminals neuropeptide Y tyrosine hydroxylase. few hyperinnervation VIPergic or SPergic nerves seen. These findings indicate that hyperactive local nervous reflexes are pathogenetic importance. To silence such activity, diseased mucosa treated...
Abstract. Autoantibodies against myeloperoxidase and elastase were found in a study of nine patients who had developed glomerulonephritis after treatment with hydralazine, but not treated hydralazine without side‐effects. Circulating IgM isotype antibodies myeloperoxidase, IgG anti‐elastase, mainly present during the initial months withdrawal drug. By contrast, initially seven patients, increased concentration all at follow‐up 4–12 years.
Summary Background Previous studies have reached conflicting conclusions regarding the efficacy of mesalazine in prevention recurrent diverticulitis. Aim To investigate and safety granules recurrence diverticulitis after acute uncomplicated Methods Two phase 3, randomised, placebo‐controlled, double‐blind multicentre trials ( SAG ‐37 ‐51) investigated patients with prior episodes (<6 months) left‐sided Patients were randomised to receive either 3 g once daily or placebo ‐37, n=345) 1.5...
Coeliac disease is an autoimmune characterized by inflammation localized to the small bowel, but less known about systemic signs of inflammation. The aim was measure cytokines T helper 1 (Th1) and 2 (Th2) cell patterns in children with screening-detected coeliac before after treatment a gluten-free diet. Serum samples selected start diet from 26 3-year-old diagnosed biopsy-proven 52 matched controls were assayed multiplex enzyme-linked immunosorbent assay (ELISA) for 10 cytokines: interferon...
<h3>BACKGROUND</h3> Antisecretory factor (AF), a 41 kDa cloned and sequenced protein, suppresses intestinal inflammation hypersecretion in animals. Endogenous AF production can be induced by dietary modifications several animal species, this feed has been shown to reduce the incidence of diarrhoeal disease weaning piglets. The role humans is not known. <h3>AIMS</h3> To study effects hydrothermally processed cereals, optimised for induction animals, added diet patients with longstanding...
To describe 8-year trends in blood pressure (BP) control, lipid and smoking habits patients with hypertension from QregPV, a primary care register the Region of Västra Götaland, Sweden.QregPV features clinical data on BP, low-density lipoprotein cholesterol (LDL-C), 392 277 or coronary heart disease diabetes mellitus any combination three diagnoses. Data routine practice have been automatically reported monthly basis to QregPV all centres Götaland (population 1.67 million) since 2010....
Strict glycaemic control has been shown to reduce the risk of developing diabetic nephropathy. In established nephropathy, however, impact on prognosis is less clear. Therefore we investigated effect long-term decline in renal function insulin-dependent patients with overt nephropathy.The study was performed at two hospital-based diabetes centres western Sweden. The an observational retrospective follow-up 158 diabetics proteinuria a mean (+/-SD) age 36+/-9 years and duration 22+/-8 years....
Abstract: The pioneering experiment by Welsh et al. (Immunological Lett 1991:29:167–170) connecting a pig kidney to the human circulation has been repeated in modified manner. Two volunteer dialysis patients were pretreated daily plasmapheresis on days ‐2,‐1, and 0 remove naturally occurring anti‐pig xenoantibodies. lymphocytotoxic liters reduced from 1:8 1:2 patient 1 1:1 2. No steroids or immunosuppressive drugs administrated before during experiments. A sterile was extracorporeally (“ex...
Plasma as well renal clearance of 51Cr-EDTA, serum creatinine, plasma beta-2-microglobulin and endogenous creatinine were compared evaluated in patients with diabetic nephropathy control disease other origin. The difference between the that is extrarenal clearance, was found to be higher diabetics than (7.0 vs. 3.5 ml/min; p < 0.001). correlated glomerular filtration rate (GFR), but individual case GFR not at all predictable from creatinine. did correlate better 51Cr-EDTA permit an earlier...
Seven patients with acute renal failure after ingestion of analgesic drug combinations including paracetamol were seen. They presented oliguric and restitution function was complete. Only 2 had severe liver damage no signs abnormality. Renal biopsies, studied by light electron microscopy, in 3 showed focal tubular epithelial cell necrosis. Focal vascular damage, predominantly endothelial cells, also present all specimens. This injury found various locations the kidney, glomerular peritubular...
Abstract: Pig kidneys were extracorporeally “ex vivo” connected to the circulation of two volunteer male dialysis patients (Breimer et al., this issue). The pretreated by daily plasmapheresis for 3 consecutive days, which reduced anti‐pig lymphocytotoxic titer from 8 2 in first patient and 1 second patient. hemagglutinating titers 32 4 No drugs, except heparin, given. perfusion lasted 65 min experiment was terminated due increased vascular resistance pig kidney. Ultrastructural investigation...