A5012346536- Hernia repair and management
- Intestinal and Peritoneal Adhesions
- Abdominal Surgery and Complications
- Colorectal Cancer Surgical Treatments
- Hemostasis and retained surgical items
- Pelvic and Acetabular Injuries
- Intraperitoneal and Appendiceal Malignancies
- Peptidase Inhibition and Analysis
- Wound Healing and Treatments
- Gastric Cancer Management and Outcomes
- Protease and Inhibitor Mechanisms
- Appendicitis Diagnosis and Management
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cell Adhesion Molecules Research
- Colorectal and Anal Carcinomas
- Blood Coagulation and Thrombosis Mechanisms
- Thyroid and Parathyroid Surgery
- Antimicrobial agents and applications
- Surgical Sutures and Adhesives
- Reconstructive Surgery and Microvascular Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Digestive system and related health
University of Gothenburg
2012-2022
Sahlgrenska University Hospital
1998-2018
Hallands sjukhus Kungsbacka
2013
Conventional meshes for hernia repair and abdominal wall reinforcement are usually made from polypropylene, polyester or other synthetic plastic materials known to promote foreign body reactions a state of chronic inflammation that may lead long-term complications. A novel approach is use resorbable implants like TIGR® Matrix Surgical Mesh. Preclinical studies have shown this mesh maintains mechanical integrity beyond the point in time where newly formed tissue capable carrying loads. This...
There are inconsistencies in the use of serum or plasma when analysing matrix metalloproteinases (MMPs) as diagnostic prognostic markers. The purpose this study was to compare concentration MMP-1, -2, -7, -8, -9 and -13 vs samples. Blood samples were obtained from sixty-five men women. Samples analysed for levels MMPs corresponding citrate serum. All expressed higher compared with (P<0.01). no differences between genders. Present demonstrated significant regarding concentrations some using...
Objective. There is evidence that transforming growth factor-β1 (TGF-β1) and matrix metalloproteinases (MMPs) play an important role in tumor invasion progression colorectal cancer. The aim of this study was to assess their utility prediction cancer-specific survival (CSS). Materials methods. 136 patients undergoing curative surgery for carcinoma were prospectively included. Samples taken from tumor-free intestinal mucosa ELISA used protein levels the tissues. Patients followed CSS. median...
Matrix metalloproteinases (MMPs) are believed to be of importance in the growth and spread colorectal cancer (CRC). MMP-9 level has been suggested as a biological predictor prognosis CRC well other types such breast cervical cancer. The purpose this study was investigate stability over time cryopreserved plasma, tumor tissue extract macroscopically tumor-free colon mucosa samples. Plasma samples were taken from patients at primary surgery analyzed for MMP-9. Aliquots same stored – 80 °C...
BackgroundMatrix metalloproteinases (MMP) are involved in the local and distant invasiveness of colorectal cancer. This study investigates prognostic value circulating matrix metalloproteinase levels patients with colon cancer.MethodsA cohort 152 was followed for more than 10 years. The correlation plasma MMP-1,-2, -7, -8, -9 survival investigated.ResultsA high level MMP-1 associated a poorer prognosis cancer (HR 2.0, 95% CI 1.1-3.9) multivariate analysis regarding 5-year cancer-specific...
• Objective: To study the morphology and proliferation of cultured fibroblasts in combination with an experimental wound-healing model using fibroblasts, without presence a hydrophobic, dialkyl carbamoyl chloride (DACC) dressing (Sorbact; Abigo Medical AB). Method: Human dermal were cell viability investigated. Proliferation was investigated XTT assay. An employed, whereby mechanical damage inflicted to surface fibroblasts. The healing closure wound then monitored DACC dressing. Results:...
Colorectal cancer is one of the most common forms cancer. Spread tumour to peritoneal cavity may lead seeding cells that adhere and invade membrane causing carcinomatosis. Matrix metalloproteinases (MMPs) play an essential role in cell invasion dissemination. The aim this study was evaluate morphology presence matrix Biopsy samples parietal peritoneum were taken from patients undergoing cytoreductive surgery for fixed formalin, dehydrated embedded paraffin prior cutting into 4-µm slices....
<b><i>Background/Aims:</i></b> To examine, compare and correlate the expressions of matrix metalloproteinase 9 (MMP-9), tissue inhibitor 1 (TIMP-1) plasminogen activator type (PAI-1) in appendiceal pre- postoperative blood samples patients undergoing surgery for clinically suspected appendicitis. <b><i>Methods:</i></b> Fifty-seven with complete were included divided into groups noninflamed appendix/lymphadenitis (n = 7), phlegmonous...
Abstract Introduction Synthetic non-resorbable mesh is almost standard in hernia surgery. However, several studies have showed negative effects of permanent implants such as chronic inflammation and complications involving different organs bordering the mesh. Such can raise risk post-operative pain (CPP). Recently promising results regarding CPP been published patients with Lateral Inguinal Hernia (LIH) using a slowly resorbable Lichtenstein technique. For this reason aim present study was...
Biological compatibility, in terms of implantation foreign mesh material hernia surgery, still needs experimental investigation. Present study develops an model using human peritoneum to the integration between tissue and different material. The ex vivo peritoneal was studied with material, monitored over time microscopy. It could be demonstrated that may kept viable culture for several weeks. Cell migration seen after 7-10 days further use a artificial environment enabling investigation...
Abstract Purpose Autologous full-thickness skin grafting (FTSG) has the potential to become an option in abdominal wall repair. An understanding of tissue remodelling extracellular matrix (ECM) is crucial as this interplay determines such parameters strength and flexibility. This cross-sectional preclinical laboratory study mice provides information on distribution collagen types metalloproteinases (MMPs) ECM FTSGs intraperitoneal onlay positions compared with internal controls. The aim was...
Purpose/Aim: Colorectal malignity is one of the most common forms cancer. The finding free intraperitoneal colorectal cancer cells during surgery has been shown to be associated with poor outcome. aim this study was develop an experimental model designed investigate adhesion peritoneal surface. Materials and methods: Two human models were developed, first using cultured mesothelial second consisting ex vivo tissue. Both subjected standardized trauma, following which labeled (Colo205)...
The fibrinolytic capacity of the peritoneum plays a pivotal role in peritoneal wound healing. During surgery balance between fibrin deposition and degradation is tilted towards deposition, leading to formation adhesions. In blood, carboxypeptidase U (CPU) stabilizes clots by retarding fibrinolysis. purpose this study was investigate whether more stable zymogen, proCPU, also present cavity and, if so, examine its origin. Levels proCPU were measured plasma serosal fluid collected during...
Background and Objectives:The role of long-term degradable implants in reducing the risk chronic postoperative pain after inguinal hernia repair is still unclear. A pilot study using a synthetic resorbable mesh Lichtenstein showed good results regarding discomfort patients with indirect (IH) without recurrences, but higher recurrence rate direct (DH). The purpose this was to assess incidence early LIH surgically treated TEP technique mesh. This first human use approach.Methods:This...
The fibrinolytic capacity of the peritoneum plays a pivotal role in peritoneal wound healing. During surgery balance between fibrin deposition and degradation is tilted towards deposition, leading to formation adhesions. In blood, carboxypeptidase U (CPU) stabilizes clots by retarding fibrinolysis. purpose this study was investigate whether more stable zymogen, proCPU, also present cavity and, if so, examine its origin. Levels proCPU were measured plasma serosal fluid collected during...