PURPOSE: To identify the risk factors for anastomotic leakage after left-sided colorectal resections with rectal anastomosis. METHODS: Forty-four patients identified from a computer-generated database were compared 44 control standardized gender, age, and operative indication. RESULTS: The mean hospital stay was significantly prolonged in group, which resulted higher total cost of treatment. preoperative variables associated included malnutrition, weight loss, hypoalbuminemia, cardiovascular...

<h3>Objective:</h3> To determine whether an intensified follow-up of patients with colorectal cancer can lead to improved reresectability and a better long-term survival. <h3>Design:</h3> A prospective randomized trial 106 patients. <h3>Setting:</h3> Oulu University Hospital, referral center in northern Finland. <h3>Patients:</h3> total consecutive who underwent radical resection for cancer, 54 whom were into conventional group 52 group. <h3>Main Outcome Measures:</h3> After 5-year...

PURPOSE: Efficient mechanical bowel preparation has been regarded as essential in preventing postoperative complications of colorectal surgery, but the necessity cleansing disputed recently. The aim this study was to evaluate outcome elective surgery patients with or without preparation. METHODS: Altogether, 267 consecutive adult admitted for open were randomly assigned either group oral polyethylene glycol electrolyte solution (138 patients) no (129 patients). Patients who unable drink...

Anemia is common in colorectal cancer (CRC) but its relationships with tumor characteristics, systemic inflammation, and survival have not been well characterized. In this study, blood hemoglobin levels erythrocyte mean corpuscular volume (MCV) were measured two independent cohorts of 148 CRC patients 208 patients, their correlation patient inflammatory markers (modified Glasgow Prognostic Score: mGPS; serum thirteen cytokines, C-reactive protein, albumin), analyzed. We found that anemia,...

A subset of colorectal cancers (CRCs) exhibits so‐called Crohn's like lymphoid reaction (CLR), an inflammatory pattern that consists numerous transmural aggregates. However, the composition these aggregates, their biological mechanisms and prognostic significance are not well‐defined. We analyzed two CRC cohorts (418 149 patients) determined clinicopathological features including survival. new method for evaluating CLR based on counting areal density follicles (CLR density) was adopted....

Prophylactic placement of a mesh has been suggested to prevent parastomal hernia, but evidence support this approach is scarce.The aim study was evaluate whether laparoscopic prophylactic, dual-component, intraperitoneal onlay around colostomy safe and prevents hernia formation after abdominoperineal resection.This prospective, multicenter, randomized controlled clinical trial.This conducted at 2 university 3 central Finnish hospitals.From 2010 2013, 83 patients undergoing resection for...

The population of Finland is aging fast, and dietary fiber consumption has decreased during the past few decades; prevalence sigmoid diverticular perforation can therefore be anticipated to increase. This study presents our experience concerning outcome 133 patients admitted a university hospital for 15-year period.One hundred thirty-three into period from 1986 2000 were identified using computer database. Clinical data reviewed database patients' records.The annual perforated diverticulitis...

A review of 96 consecutive patients who underwent palliative surgery for primary colorectal cancer was undertaken to clarify the value palliation achieved with surgical treatment. The overall rate postoperative mortality 8 percent (8 96) and morbidity 24 (23 96). 5 (3 66) after resective 17 (5 30) nonresective surgery. Three deaths were related malignant disease, three intra-abdominal infection, two formation intestinocutaneous fistulas. Of died, 1 had a tumor local visceral involvement only...

Recent studies have reported of an association between high serum apolipoprotein A1 (APOA1) levels and favorable prognosis in several malignancies, while the significance B (APOB) cancer is less well-known. In this study, we analyzed correlation APOA1 APOB levels, APOB/APOA1 ratio, their associations with clinicopathologic parameters, twenty systemic inflammatory markers, survival 144 colorectal (CRC) patients. We demonstrated that low associated advanced T-class TNM-stage but did not...

The disease outcome in colorectal cancer (CRC) can vary a wide range within the same tumour stage. aim of this study was to clarify prognostic value and determinants necrosis CRC.The areal proportion (%) tissue showing coagulative evaluated cohort 147 CRC patients correlated with basic clinicopathological characteristics, microvascular density (MVD), cell proliferation rate, KRAS BRAF mutations, survival. To validate significance necrosis, an independent 418 analysed.Tumour positively stage...

Objective. Computed tomography (CT) is the most appropriate initial imaging modality for assessment of acute diverticulitis. The aim here was to determine usefulness C-reactive protein (CRP) in predicting severity diverticulitis process and need a CT examination. Methods. CRP values 350 patients who presented first time with symptoms underwent on admission Oulu University Hospital were compared findings clinical parameters by means both univariate multivariate analyses. Results. receiver...

The purpose of this prospective randomized study was to compare robot-assisted and laparoscopic ventral rectopexy procedures for posterior compartment procidentia in terms restoration the anatomy using magnetic resonance (MR) defaecography.Sixteen female patients (four with total prolapse, twelve intussusception) underwent mesh (RVMR) 14 (two (LVMR). Primary outcome measures were perioperative parameters, complications as assessed by MR defaecography, which performed preoperatively 3 months...

Cancer cachexia is a complex wasting syndrome affecting patients with advanced cancer, systemic inflammation as key component in pathogenesis. Protein degradation and release of amino acids (AAs) skeletal muscle are stimulated cachexia. Here, we define factors contributing to serum AA levels colorectal cancer (CRC). Serum nine AAs were characterised 336 CRC their relationships 20 markers inflammatory reaction, clinicopathological features cancers patient survival analysed. Low glutamine...

PURPOSE: The natural history of patients admitted because acute diverticulitis is largely unknown, and the selection for surgical treatment varies notably. This study presents our experience concerning outcome 366 during a 10-year period. METHODS: Three hundred sixty-six to hospital with from 1981 1990 were identified computer database, their clinical data up end 1996 reviewed database patient records. RESULTS: There significantly more males than females in age group less 50 years old, young...

Matrix metalloproteinase-8 (MMP-8) is a protease mainly expressed by neutrophils that cleaves numerous substrates, including collagens and cytokines. We have previously shown serum MMP-8 levels increase in colorectal cancer (CRC) correlate with distant metastasis. However, short follow-up our prospective cohort did not enable survival analyses at the time of first publication.Preoperative were measured immunofluorometric assay 271 CRC patients related to clinicopathological parameters,...

Increased inflammatory cell infiltration correlates to improved survival in colorectal cancer (CRC). Development and progression of CRC is associated with alterations serum cytokine levels but their significance not well defined. In this study, we investigated the relationships between 13 cytokines densities eight types tumor infiltrating cells impact on disease-free (DFS), cancer-specific (CSS) overall (OS) a prospectively recruited group 147 patients. There were strong positive...