A5051447354- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal disorders and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Glycosylation and Glycoproteins Research
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Congenital Diaphragmatic Hernia Studies
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- Diverticular Disease and Complications
- Neonatal Respiratory Health Research
- Steroid Chemistry and Biochemistry
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Multiple and Secondary Primary Cancers
- Cell death mechanisms and regulation
- Pleural and Pulmonary Diseases
- Inhalation and Respiratory Drug Delivery
- Gastroesophageal reflux and treatments
- Colorectal and Anal Carcinomas
- Cytokine Signaling Pathways and Interactions
- Genomics and Phylogenetic Studies
University of Oulu
2002-2023
Oulu University Hospital
2003-2023
Länsi-Pohjan Sairaanhoitopiirin Kuntayhtymä
2003
University of Helsinki
1978
Colorectal serrated adenocarcinoma originates from adenoma, but definite histological criteria have not yet been established. It presents with frequent DNA microsatellite instability (MSI), the frequency of low-level (MSI-L) and high-level MSI (MSI-H) expression mismatch-repair (MMR) enzymes in are known. To address these questions, morphological for cancers were established, their validity was tested, analysis performed NIH consensus markers MMR enzyme immunohistochemistry hMLH1, hMSH2,...
Aims Until the launch of International Association for Study Lung Cancer/American Thoracic Society/European Respiratory Society adenocarcinoma classification in 2011, there were no uniform histological grading criteria pulmonary adenocarcinomas. The current highlights prognostic importance various growth patterns observed these morphologically heterogeneous neoplasias. In this study, we aimed to evaluate classic parameters malignancy correlation with and patient outcomes a series 112...
Abstract Background Chronic obstructive pulmonary disease (COPD) is characterized by structural changes in alveoli and airways. Our aim was to analyse the numbers of alpha-smooth muscle actin (α-SMA) positive cells, as a marker myofibroblasts, different lung compartments non-smokers smokers with normal function or COPD. Methods α-SMA, tenascin-C (Tn-C) EDA-fibronectin alveolar level airways were assayed immunohistochemistry quantified image analysis. Immunohistochemical findings correlated...
The aim of this study was to assess the significance interleukin 6 gene polymorphism ‐174 in gastric cancer risk. G/C (rs1800795) polymorphisms analyzed cancer, peptic ulcer, and nonulcer dyspepsia patients healthy control subjects data were correlated with histopathological features patients' biopsies. GG GC genotypes have been previously associated high serum levels. We discovered that are an increased risk diffuse histologic subtype carcinomas (OR: 6.809, P = 0.034), but absent intestinal...
Toll-like receptor 4 is a part of the innate immune system and recognizes Helicobacter pylori lipopolysaccharide. The goal this study was to analyze role polymorphisms +896 (rs4986790) +1196 (rs4986791) in pathogenesis related gastroduodenal diseases relation gastric secretion inflammation. polymorphisms, serum gastrin-17 pepsinogen I II concentrations were determined, gastroscopies with histopathological analyses performed 216 dyspeptic patients. As genotype controls, 179 controls 61 cancer...
Mucin-1 (MUC1) affects cancer progression in lung adenocarcinoma, and its aberrant expression pattern has been correlated with poor tumor differentiation impaired prognosis. In this study, the immunohistochemical of MUC1 Mucin-4 (MUC4) was analyzed a series 106 surgically operated stage I–IV pulmonary adenocarcinomas. immunohistochemistry evaluated according to Nagai classification, profile tumors detailed clinical histological data. The effect cigarette smoke on cell lines examined using...
Fas (CD95, APO-1) is widely expressed on lymphatic cells, and by interacting with its natural ligand (Fas-L), induces apoptosis through a complex caspase cascade. In this study we sought to survey Fas-L expression in vascular sinusoidal structures of human reactive lymph nodes. Immunohistochemical was present all paracortical high endothelial venules (HEVs), cells lining the marginal sinus wall, few lymphocytes, but only occasionally non-HEV endothelium. zone over 60% vessels HEVs showed...
Background: Certain variants of NHL repeat (named after NCL-1, HT2A and LIN-41)-containing protein 2 (NHLRC2) gene have been linked to severe fibrotic interstitial lung disease in children. The aim the current study was evaluate expression NHLRC2 cell tissue samples from patients with adenocarcinoma (ADC) squamous carcinoma (SCC). Methods: studied by immunohistochemistry (102 ADC, 111 SCC), mRNA situ hybridization (4 3 Western blot analysis (3 SCC). immunohistochemical measured image...
AIM:Lymphocytic gastritis is commonly associated with Helicobacter pylori infection.The presence of glandular atrophy and foveolar hyperplasia in lymphocytic suggests abnormalities cell proliferation differentiation, forming a potential link the suspected association gastric cancer.Our aim was to compare epithelial morphology H without features gastritis, evaluate effect treatment. METHODS:We studied 14 patients infection.For controls, we selected matched dyspeptic participating another...