A5025311140- Celiac Disease Research and Management
- Eosinophilic Esophagitis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mast cells and histamine
- Food Allergy and Anaphylaxis Research
- Digestive system and related health
- Asthma and respiratory diseases
- Microscopic Colitis
- Adolescent and Pediatric Healthcare
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Childhood Cancer Survivors' Quality of Life
- Infant Nutrition and Health
- Renin-Angiotensin System Studies
- Blood Coagulation and Thrombosis Mechanisms
- Diabetes Management and Research
- Congenital Heart Disease Studies
- Family and Disability Support Research
- Family Support in Illness
- Child Nutrition and Feeding Issues
- Neonatal Respiratory Health Research
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Sarcoidosis and Beryllium Toxicity Research
- Immunodeficiency and Autoimmune Disorders
Tampere University
2005-2024
Tampere University Hospital
1998-2024
Central Finland Health Care District
2011-2023
Oulu University Hospital
1998-2014
Kuopio University Hospital
2014
Turku University Hospital
2014
Vaasa Central Hospital
2014
South Karelia Central Hospital
2014
Wihuri Research Institute
1991-2011
University of Oulu
1999-2011
The ESC Guidelines represent the views of and were arrived at after careful consideration available evidence time they written.Health professionals are encouraged to take them fully into account when exercising their clinical judgement.The guidelines do not, however, override individual responsibility health make appropriate decisions in circumstances
Wheat, rye, and barley proteins induce celiac disease, an autoimmune type of gastrointestinal disorder, in genetically susceptible persons. Because the disease may be underdiagnosed, we estimated prevalence tested hypothesis that assays for serum autoantibodies can used to detect untreated positive findings correlate with specific HLA haplotypes.
This study was designed to assess the epidemiology, characteristics, and outcome of cardiac sarcoidosis (CS) in Finland. We identified retrospect all adult (>18 years age) patients diagnosed with histologically confirmed CS Finland between 1988 2012. A total 110 (71 women) 51±9 age (mean±SD) were found followed up for events end 2013. The annual detection rate increased >20-fold during 25-year period, reaching 0.31 1×10(5) adults 2008 2012 prevalence 2.2 1×10(5). Nearly two thirds had...
Abstract Aim: To study the macronutrient and energy contents of human milk fractions during first 6 mo lactation. Study design: A total 483 samples, including 52 pairs fore‐ hindmilk samples from 20 mothers, 253 53 donor mothers 126 36 preterm infants, were collected longitudinally, starting at 1 wk postpartum continuing monthly up to mo. Protein, lactose fat measured density estimated. Results: The protein content was significantly lower in than or months In milk, declined consistently 2.0...
As a source of transforming growth factor beta1 (TGF-beta1), mast cells have been implicated as potential effector in many pathological processes. However, the mechanisms by which express, secrete, and activate TGF-beta1 remained vague. We show here means RT-PCR, immunoblotting, immunocytochemistry that isolated rat peritoneal synthesize store large latent their chymase 1-containing secretory granules. Mast cell stimulation degranulation results rapid secretion TGF-beta1, is converted 1 into...
The present study was done to assess the role of sudden cardiac death (SCD) among presenting manifestations and fatalities from sarcoidosis (CS).We analysed altogether 351 cases CS year 1998 through 2015 in Finland. There were 262 patients with a clinical diagnosis treatment CS, 27 an initial lifetime giant cell myocarditis that later converted 62 detected at autopsy identified by screening >820 000 certificates national cause-of-death registry. total case series comprised 253 females 98...
Background: Symptomatic high-grade atrioventricular block (AVB) is the most common and often only presenting manifestation (lone AVB) of cardiac sarcoidosis. Implantation an intracardiac cardioverter defibrillator instead a pacemaker recommended, but true risk fatal arrhythmia, one incident to lone AVB in particular, remains poorly known. Methods: We used Myocardial Inflammatory Diseases Finland Study Group Registry analyze presentations, left ventricular (LV) function, therapy, arrhythmias...
Abstract Objective The aim was to clarify how families with physically and/or intellectually disabled children cope, what kind of coping strategies they use and the good poor capacities differ. Methods parents eight (aged 8–10 years) physical intellectual disability were interviewed twice, data elicited in these interviews analysed qualitatively using grounded theory method. Results Information acceptance, family co‐operation social support related most frequently used. Half seemed have...
Objective Cardiac mast cells participate in myocardial dysfunction, but the mechanisms are presently unknown. Design By examining spontaneously hypertensive rats (SHRs) during their entire lifespan, we attempted to define role of induction cardiac hypertrophy and transition heart failure. Methods results contrast normotensive littermates, hearts newborn SHRs already contained cells. In prehypertensive (2-week-old) SHRs, increased expression c-kit soluble stem cell factor correlated with an...
ABSTRACT Objectives: Congenital chloride diarrhea (CLD) is a rare, autosomal recessive disorder of intestinal Cl − /HCO 3 exchange caused by mutations in the SLC26A3 gene and characterized persistent rich from birth. Treatment symptomatic replacement therapy with NaCl KCl has been shown to be effective children, but long‐term prognosis remains unclear. We studied largest known cohort patients evaluate outcome CLD search for extraintestinal manifestations. Methods: This cross‐sectional...
Background Cardiac sarcoidosis (CS) and giant cell myocarditis (GCM) share many histopathologic clinical features. Whether they are parts of a one‐disease continuum has been discussed. Methods Results We compared medical record data 351 CS 28 GCM cases diagnosed in Finland since the late 1980s followed until February 2018 for composite end point cardiac death, aborted sudden heart transplantation. Heart failure was presenting manifestation 50% versus 15% ( P <0.001), high‐grade...
Background Data from in vitro studies suggest that both chymase and ACE contribute to the local generation of angiotensin (Ang) II heart. The enzyme kinetics under vivo conditions are unclear. We thus studied Ang by cardiac tissue presence interstitial fluid (IF) contains a variety naturally occurring protease inhibitors. Methods Results I was incubated with heart homogenate IF. IF obtained human skin contained substantial amounts inhibitors activity, concentration α 1 -antitrypsin being 35%...
OBJECTIVE: To evaluate social maturation and psychiatric morbidity in young adults treated for epilepsy during their childhood. METHODS: Eighty one (43 women, 38 men, mean age 22.3 years) with childhood were interviewed about development symptoms. The results compared those from 211 randomly selected controls (106 105 23.2 years). RESULTS: Compared the patients had more often not succeeded passing normal comprehensive school (20% v 2%) or left at secondary level (53% 46%) remained without...
Background To discover the prevalence and significance of lymphonodular hyperplasia (LNH) lower gastrointestinal tract, authors did a retrospective analysis consecutive series children using colonoscopy to evaluate persistent severe symptoms. The also sought in more detail how often subjects with LNH terminal ileum (TI) or colon show an association food allergy (FA). Methods included 140 evaluated at Oulu University Hospital colonoscopy, which extended TI 74 these children. A total 102...
The prognosis of allergic rhinitis was studied in 154 children aged 3-17 years at diagnosis by means a detailed questionnaire administered 8-11 later. symptoms had completely disappeared only 15 (10%) patients. conjunctival symptoms, however, or were controlled successfully topical drug therapy almost all, and 77 (50%) managing without medication for rhinitis. Twenty-five (23%) the 110 with seasonal perennial disease follow-up, contrast to seven (16%) 44 originally who follow-up. Asthma...
Abstract Secretory granules exocytosed from rat serosal mast cells bind low density lipoprotein (LDL), and on being phagocytosed by macrophages, carry the bound LDL into these (Kokkonen, J. O., Kovanen, P. T. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 2287-2291). The binding of to is mediated through interactions between apolipoprotein B (apoB) component heparin proteoglycan granules. Here we report how degradation apoB neutral proteases affects granule-mediated uptake cultured mouse...
The uptake of low density lipoprotein (LDL) by cultured mouse macrophages was markedly promoted isolated rat mast cell granules present in the culture medium. granule-mediated LDL enhanced rate cholesteryl ester synthesis macrophages, result being accumulation esters these cells. Binding to essential for process prevented treating with avidin or protamine chloride 1,2-cyclohexanedione, all which inhibit binding granules. Inhibition granule phagocytosis cytochalasin B also abolished LDL....
Because bradykinin (BK) appears to have cardioprotective effects ranging from improved hemodynamics antiproliferative effects, inhibition of BK-degrading enzymes should potentiate such actions. The purpose this study was find out which are responsible for the degradation BK in human plasma. Human plasma healthy donors ( n = 10) incubated with presence or absence specific enzyme inhibitors. At high (micromolar) concentrations, mostly (>90%) degraded by carboxypeptidase N (CPN)-like...
To describe the meal patterns and food use on weekdays among 10- to 11-year-old Finnish children analyse these in relation family's socio-economic status child's behaviour.Cross-sectional study a cohort of 404 aged 10-11 years rural town Ylivieska, mid-western Finland.A food-frequency questionnaire including questions Child Behaviour Checklist (CBCL) completed by parents child together.Practically all (99%) ate breakfast regularly, 94% had daily school lunch 80% dinner at home daily....
The secretory granules of rat serosal mast cells are able efficiently to degrade the apolipoprotein B component low density lipoproteins (LDL) (Kokkonen,
The social status of 52 disabled young adults (29 men, 23 women) was reviewed at the age 19 to 25 years, and compared with that 209 age-matched controls. 40 had successfully completed elementary school 10 high-school. 28 gone on basic further education 11 progressed more advanced levels. 35 per cent study group controls no education. Half were receiving disability benefit 12 occupation outside home. There little difference in present employment between groups, but experienced twice as much...