A5024372407- Cardiac Valve Diseases and Treatments
- Cardiac Fibrosis and Remodeling
- AI in cancer detection
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Colorectal Cancer Screening and Detection
- Hormonal Regulation and Hypertension
- Cardiomyopathy and Myosin Studies
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Renin-Angiotensin System Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Vitamin K Research Studies
- Morphological variations and asymmetry
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Bone health and treatments
- Lipoproteins and Cardiovascular Health
- Signaling Pathways in Disease
- Apelin-related biomedical research
- Optical Polarization and Ellipsometry
- TGF-β signaling in diseases
- ATP Synthase and ATPases Research
- Leaf Properties and Growth Measurement
University of Oulu
2008-2023
Oulu University Hospital
2011-2023
Physico-Technical Institute
2018
National Research University of Electronic Technology
2018
Saint Petersburg State Electrotechnical University
2018
University of Turku
2002
University of Aberdeen
2002
University of Eastern Finland
2002
Bisphosphonates are currently the most important class of antiresorptive drugs used for treatment diseases with excess bone resorption. Recent studies have shown that bisphosphonates can be divided into two groups distinct molecular mechanisms action depending on nature R(2) side chain. Alendronate, like other nitrogen-containing bisphosphonates, inhibits resorption and causes apoptosis osteoclasts cells in vitro by preventing post-translational modification GTP-binding proteins isoprenoid...
Calcific aortic valve disease (CAVD) is a progressive pathological condition with no effective pharmacological therapy. To identify novel molecular pathways as potential targets for pharmacotherapy, we studied microRNA (miRNA) profiles of heavily stenotic valves (AS). One the most upregulated miRNAs in AS compared to control was miR-125b (1.4-fold; P < 0.05). CAVD-related changes gene expression, DNA microarray analysis performed, including an intermediate fibro(sclero)tic stage disease....
Background Activation of the renin-angiotensin-system (RAS) plays a key pathophysiological role in heart failure patients with hypertension and myocardial infarction. However, function (pro)renin receptor ((P)RR) is not yet solved. We determined here direct functional structural effects (P)RR heart. Methodology/Principal Findings was overexpressed by using adenovirus-mediated gene delivery normal adult rat hearts up to 2 weeks. into anterior wall left ventricle decreased ejection fraction...
Oxidative stress and inflammation play an important role in the progression of atherosclerosis. Transcription factor NF-E2-related 2 (Nrf2) has antioxidant anti-inflammatory effects vessel wall, but paradoxically, global loss Nrf2 apoE deficient mice alleviates In this study, we investigated effect deficiency on early advanced atherogenesis alternative models atherosclerosis, LDL receptor (LDLR-/-), LDLR-/- expressing apoB-100 only (LDLR-/- ApoB100/100) having a humanized lipoprotein...
Background: Whole slide images (WSIs, digitized histopathology glass slides) are large data files whose long-term storage remains a significant cost for pathology departments. Currently used WSI formats based on lossy image compression alogrithms, either using JPEG or its more efficient successor 2000. While the advantages of 2000 algorithm (JP2) commonly recognized, parameters have not been fully optimized WSIs. Methods: We defined an parametrization compression, designated JP2-WSI, to be...
Aortic valve stenosis (AS) is an actively regulated process like atherosclerosis, which accompanied by changes e.g. in endothelin-related genes. However, the role of endothelin peptides AS unknown. We characterized expression system aortic valves patients with normal (n = 12), regurgitation, and fibrosis 6) 18) reverse-transcriptase–polymerase chain reaction immunohistochemistry. The number endothelin-1 (ET-1) positive cells was higher than control valves, while levels ET-1 mRNA did not...
Both obesity and exposure to chemicals may induce non-alcoholic fatty liver disease (NAFLD). Pregnane X Receptor (PXR) is a central target of metabolism disrupting disturbs hepatic glucose lipid metabolism. We hypothesized that the metabolic consequences PXR activation be modified by existing associated dysfunction.Wildtype knockout male mice were fed high-fat diet dysfunction. was activated with pregnenolone-16α-carbonitrile. Glucose metabolism, hepatosteatosis, insulin signaling, uptake,...
The phosphatase and actin regulator 1 (PHACTR1) locus is a very commonly identified hit in genome-wide association studies investigating coronary artery disease myocardial infarction (MI). However, the function of PHACTR1 heart still unknown. We characterized mechanisms regulating Phactr1 expression heart, used adenoviral gene delivery to investigate effects on cardiac function, analyzed relationship between MI associated allele human subjects. mRNA protein levels were markedly reduced (60%,...
Calcific aortic valve disease (CAVD) is an atheroinflammatory process; finally it leads to progressive calcification of the valve. There no effective pharmacological treatment for CAVD and many underlying molecular mechanisms remain unknown. We conducted a proteomic study reveal novel factors associated with CAVD.We compared valves from patients undergoing valvular replacement surgery due non-calcified insufficiency (control group, n = 5) stenotic group (n 7) using two-dimensional difference...
Background.Cardiovascular diseases are the most important cause of death in patients with impaired kidney function. Left ventricular hypertrophy (LVH), cardiac interstitial fibrosis and cardiovascular calcifications characteristic chronic renal insufficiency (CRI). Periostin is a fibrogenesis- calcification-related matricellular protein re-expressed adult tissues undergoing remodelling response to pathological stimuli. The role periostin CRI-induced LVH unknown.
In this study, we utilize the properties of polarized light for analysis paraffin-embedded breast cancer samples. We perform measurements full Stokes vector back-reflected radiation and calculate degree polarization as a diagnostic criterion separation healthy sample sections. show that circularly scattered within is sensitive to presence cells. The reflected was found be most parameter reliable differentiation tissue. highest contrast between cancerous normal regions observed probing...
Abstract The use of molecular markers in the diagnostics gliomas aids histopathological diagnosis and allows their further classification into clinically significant subgroups. aim this study was to characterize methylation pattern O 6 ‐methylguanine‐DNA methyltransferase ( MGMT ) promoter, gene copy number aberrations, isocitrate dehydrogenase I (IDH1) mutation gliomas. We studied 51 (15 oligodendrogliomas, 18 oligoastrocytomas, 3 astrocytomas, 15 glioblastomas) by pyrosequencing, array...
Aims In a recent genome-wide association study, WD-repeat domain 12 (WDR12) was associated with early-onset myocardial infarction (MI). However, the function of WDR12 in heart is unknown. Methods and Results We characterized cardiac expression WDR12, used adenovirus-mediated gene delivery to examine effects on left ventricular (LV) remodeling, analyzed relationship between MI allele human subjects. LV protein levels were increased patients dilated cardiomyopathy rats post-infarction. normal...
Progress in terahertz spectroscopy and imaging is mostly associated with femtosecond laser-driven systems, while solid-state sources, mainly sub-millimetre integrated circuits, are still an early development phase. As simple cost-efficient emitter as a Gunn oscillator could cause breakthrough the field, provided its frequency limitations be overcome. Proposed here application of recently discovered collapsing field domains effect that permits sub-THz oscillations sub-micron semiconductor...