A5065080474- Congenital Diaphragmatic Hernia Studies
- Childhood Cancer Survivors' Quality of Life
- Testicular diseases and treatments
- Acute Lymphoblastic Leukemia research
- Blood groups and transfusion
- Maternal Mental Health During Pregnancy and Postpartum
- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Adolescent and Pediatric Healthcare
- Neonatal Respiratory Health Research
- Congenital Anomalies and Fetal Surgery
- Neuroblastoma Research and Treatments
- Congenital heart defects research
- Pharmacological Effects and Toxicity Studies
- Lymphoma Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Cardiac tumors and thrombi
- Congenital Heart Disease Studies
- Sarcoma Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Soft tissue tumor case studies
- Effects of Radiation Exposure
- Infant Development and Preterm Care
- Myasthenia Gravis and Thymoma
- Radiation Dose and Imaging
Walter Reed National Military Medical Center
2019-2025
Uniformed Services University of the Health Sciences
2020-2025
National Cancer Institute
2020-2024
Division of Cancer Epidemiology and Genetics
2020-2024
Tripler Army Medical Center
2022
Palmetto Hematology Oncology
2021
National Institutes of Health
2021
Western Maryland Health System
2020
Republic of Korea Army
2018
Background Pleuropulmonary blastoma (PPB), the hallmark tumour associated with DICER1 -related predisposition, is characterised by an age-related progression from a cystic lesion (type I) to high-grade sarcoma mixed and solid features II) or purely III). Not all PPBs progress; type Ir (regressed), hypothesised represent regressed non-progressed I PPB, air-filled, lacking primitive sarcomatous component. This study aims evaluate prevalence of lung cysts detected CT scan in adolescents adults...
There is limited research on cancer incidence in pediatric and adolescent/young adult patients using health care claims data no standard algorithm for such a query. This study aimed to establish an estimate rates multiple types from 2013 2017 within the Military Health System compare them reported National Cancer Institute Surveillance, Epidemiology, End Results (SEER) program. The Data Repository was queried by International Classification of Diseases 9 10 codes look-back-periods identify...
Abstract Background Pleuropulmonary blastoma (PPB) is the most common lung cancer of infancy and early childhood. Type I PPB a purely cystic lesion that has microscopic population primitive small cells with or without rhabdomyoblastic features may progress to type II III PPB, whereas Ir lacks cells. Methods Children suspected were enrolled in International PPB/ DICER1 Registry. Pathology was centrally reviewed, follow‐up ascertained annually. Results Between 2006 2022, 205 children had...
While all childhood cancers are rare, tumors that particularly infrequent or underrepresented within pediatrics studied under the umbrella of Children's Oncology Group Rare Tumor committee, divided into Retinoblastoma and Infrequent subcommittees. The subcommittee has traditionally included an emphasis on globally rare such as adrenocortical carcinoma, nasopharyngeal those in young children, despite being common adolescents adults, colorectal thyroid melanoma. Pleuropulmonary blastoma,...
DICER1 syndrome is a rare paediatric autosomal dominant inherited disorder predisposing to various benign and malignant tumours. It caused by germline pathogenic variant in , the second hit for tumour development usually missense hotspot ribonuclease IIIb domain. While variants account about 60% of ovarian Sertoli-Leydig cell tumours, no -related testicular stromal tumours have been described. Here we report first two cases children carrying variant: case Sertoli Leydig diagnosed at 2 12...
Nasal chondromesenchymal hamartomas are benign, rare nasal tumors associated with DICER1 pathogenic germline variation. They can be locally destructive and recurrent if not completely resected.In this single-center, case-control study, otorhinolaryngology evaluations review of systems questionnaires DICER1-carriers controls enrolled in the Natural History Study at National Cancer Institute were collected. Review these medical records analyzed to determine experienced different sinonasal...
Background: Postpartum depression (PPD) affects between 5-25% of new mothers. This rate can be as much double for low-income families, young parents and those individuals who have previously suffered from depression. The spectrum depressive symptoms range “postpartum baby blues” to postpartum and/or psychosis. population surveyed in this study is a very with average delivery age 22-26 years lower educational level. In addition, the an isolated location central Alaska, where deployment...
We sought to compare survival outcomes of sarcomas in the pediatric and adolescent/young adult populations with universal care access Military Health System (MHS) those from United States general population.We compared data Department Defense's (DoD) Automated Central Tumor Registry (ACTUR) National Cancer Institute's (NCI) Surveillance, Epidemiology, End Results (SEER) program on overall patients 24 years or younger histologically microscopically confirmed sarcoma between diagnosed January...
Hyperhemolysis is a life-threatening condition of exaggerated hemolysis red blood cells which occurs in patients receiving chronic transfusion therapy. We present 19-year-old male with the β-thalassemia major an episode hyperhemolysis. Hemolysis was initially unresponsive to immunosuppression but responded after addition eculizumab. Several weeks stabilization, returned; also managed and presents significant challenges due underlying dysfunctional erythropoiesis dependence. Aggressive...
Primary mediastinal large B-cell lymphoma (PMBCL) is a rare, non-Hodgkin, thought to originate from thymic B cells, which occurs primarily in young adults such as the active duty population. presents mass, posing risks cardiopulmonary safety of patients and challenging routine approach diagnosis. We describe case 23-year-old male sailor who presented sick call on his ship while port with shortness breath, night sweats, 50-pound weight loss, pruritic punched-out lesions all extremities. An...
We describe a 21-month-old male with relapsed clear cell sarcoma of the kidney receiving enteral nutrition who experienced recurrent, ketotic hypoglycemia. During relapse therapy, he had recurrent hypoglycemia episodes, in setting hematochezia and diarrhea. Evaluation revealed low carnitine levels. He received supplementation oral levocarnitine throughout remainder treatment, resulting normalization serum levels no further believe adverse effects chemotherapy on his single gastrointestinal...
Introduction: Hyperhemolysis is a life-threatening condition of exaggerated hemolysis red blood cells which occurs in patients receiving chronic transfusion therapy. Results: We present 19-year-old male with β-thalassemia major an episode hyperhemolysis. Hemolysis was initially unresponsive to immunosuppression, but responded the addition eculizumab. Several weeks after stabilization, returned also successfully managed immunosuppression and Discussion: unique due underlying dysfunctional...