A5002259204- Anesthesia and Neurotoxicity Research
- Cancer, Stress, Anesthesia, and Immune Response
- Flavonoids in Medical Research
- Neurological Disease Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Smoking Behavior and Cessation
- Neurological Disorders and Treatments
- Traditional Chinese Medicine Studies
- Pregnancy and Medication Impact
- Pancreatitis Pathology and Treatment
- Sepsis Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Cardiac Ischemia and Reperfusion
- RNA Research and Splicing
- Eicosanoids and Hypertension Pharmacology
- Glioma Diagnosis and Treatment
- Acne and Rosacea Treatments and Effects
- Traditional Chinese Medicine Analysis
- Anesthesia and Sedative Agents
- Dermatology and Skin Diseases
- Anesthesia and Pain Management
- Pancreatic function and diabetes
- Transplantation: Methods and Outcomes
- interferon and immune responses
- Medicinal Plant Pharmacodynamics Research
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2020-2024
Affiliated Hospital of Shaanxi University of Chinese Medicine
2024
Shaanxi University of Chinese Medicine
2024
Qingdao Agricultural University
2023-2024
University of Science and Technology of China
2020-2023
Zhengzhou University
2022-2023
Liaoning Normal University
2022-2023
Beijing University of Chinese Medicine
2019-2023
Affiliated Hospital of Nantong University
2021-2022
Nantong University
2021-2022
Abstract Background and aims Cardiovascular disease (CVD) is associated with inflammation abnormal lipid metabolism. However, a single inflammatory index or cannot accurately predict the prognosis of CVD independently because it prone to be affected by various confounding factors. Methods This population-based cohort study included 6,554 participants from China Health Retirement Longitudinal Study (CHARLS) investigate correlations. In present study, occurrence events such as stroke heart was...
Abstract Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase belonging to class III histone deacetylases. Previous studies have shown that SIRT1 involved in kidney physiology regulation and protects the from various pathological factors. However, underlying mechanisms behind its function yet be fully elucidated. In our study, we found ablation of Sirt1 renal interstitial cells resulted more severe damage fibrosis unilateral ureteral obstruction (UUO) model...
Abstract Background A large number of preclinical studies have shown that local anesthetics a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There are few the role in cancer stem cells. This study aimed to determine possible glioblastoma (GSC) self-renewal underlying molecular mechanisms. Methods The effects GSCs were investigated through vitro vivo assays (i.e., Cell Counting Kit 8, spheroidal formation assay, double...
Abstract To explore the relationship between physical exercise and smoking behavior among Chinese residents aged 16 years older. Analysis based on 29,466 validated cases in 2018 China Family Panel Studies (CFPS 2018). The chi-square test Mann–Whitney U were used for comparative analysis groups. Logistic regression was to behavior. Gender birth cohort differences explored stratified using gender as variables, respectively. Robustness testing multiple linear a replacement data approach. There...
Obesity has emerged as a global health crisis, with its pathogenesis being closely linked to metabolic dysregulation in brown adipose tissue (BAT). However, the underlying mechanisms by which high-fat diets and environmental endocrine disruptors, such bisphenol A (BPA), affect BAT remain largely unknown. This study was conducted investigate how combined exposure BPA diet influences function development of obesity via VEGF/VEGFR2/PI3K/AKT pathway.Male C57BL/6J mice were randomly assigned four...
This study aims to describe the administration of propofol in combination with remifentanil for induction general anesthesia during cesarean section (CS). Our aim was evaluate its impact on drug concentrations maternal and neonatal blood at different delivery (I–D) intervals as well effect newborns. In this double-blind randomized controlled study, patients undergoing elective CS were administered short (n = 20) or long I–D intervals. Anesthesia induced 1 mg/kg μg/kg maintained by continuous...
Abstract Glioblastoma (GBM) is associated with an increasing mortality and morbidity considered as aggressive brain tumor. Recently, extensive studies have been carried out to examine the molecular biology of GBM, progression GBM has suggested be correlated tumor immunophenotype in a variety studies. Samples current study were extracted from ImmPort TCGA databases identify immune-related genes affecting prognosis. A total 92 displaying significant correlation prognosis mined, shrinkage...
Chronic kidney disease (CKD) is often associated with muscle atrophy. However, the underlying molecular mechanisms are still not well understood. Here, we treated 5/6-nephrectomized (5/6Nx) rats resveratrol and found that this treatment greatly improves renal function as evidenced by reduced proteinuria cystatin C. Moreover, ameliorates fibrosis reducing transforming growth factor β (TGF-β) connective tissue (CTGF). Meanwhile, atrophy in these 5/6Nx was largely attenuated resveratrol....
Cardiac hypertrophy is a common pathological process of various cardiovascular diseases, which often accompanied with structural and electrical remodeling, can even lead to sudden cardiac death. However, its molecular mechanism still remains largely unknown. Here, we induced cardiomyocyte by angiotensin II (Ang II), found that miR-27a-3p hypertrophy-related genes were up-regulated. Further studies showed miR-27a-3p-inhibitor alleviate myocardial remodeling. Moreover, luciferase assay...
Objective The agranulocytosis-associated perianal infection (PI) rate ranges from 60% to 100% among patients with hematopoietic malignancies. In this study, we assessed the efficacy of a quality control circle (QCC) minimize PI rate. Methods Among 274 severe immunodeficiency (agranulocytosis ≥2 weeks) in our bone marrow transplantation center, was 17.20%. A QCC established following 10 steps plan-do-check-act (PDCA) model; scientifically supported by culturing bacterial colony patients' skin...
Scutellaria baicalensis stem-leaf total flavonoid might attenuate learning/memory impairment and neuronal loss in rats induced by amyloid beta-peptide. This study aimed to explore the effects of on beta-peptide-induced apoptosis expression apoptosis-related proteins rat hippocampus. Male Wistar were given intragastric administration flavonoid, 50 or 100 mg/kg, once per day. On day 8 after administration, 10 μg beta-peptide (25-35) was injected into bilateral hippocampus induce apoptosis. 20,...
Abstract Background Propofol is a commonly used anesthetic. However, its effects on glioma growth and recurrence remain largely unknown. Methods The effect of propofol was demonstrated by series in vitro vivo experiments (spheroidal formation assay, western blotting, xenograft model). acyl-biotin exchange method liquid chromatography-mass spectrometry assays identified palmitoylation proteins mediated the domain containing Asp-His-His-Cys family. Western co-immunoprecipitation, quantitative...
Type 2 diabetes mellitus (T2DM) therapy is facing the challenges of long-term medication and gradual destruction pancreatic islet β-cells. Therefore, it timely to develop oral prolonged action formulations improve compliance, while restoring β-cells survival function. Herein, we designed a simple nanoparticle with enhanced absorption pancreas accumulation property, which combined apical sodium-dependent bile acid transporter-mediated intestinal uptake lymphatic transportation. In this...
Chronic postsurgical pain (CPSP) is a common complication after surgical procedures. Radical resection of esophageal cancer complex procedure, one the most extensive and traumatic procedures in oncological surgery, incidence postoperative chronic high, seriously affecting patients' recovery. Therefore, this study aimed to investigate CPSP patients with analyze risk factors associated its occurrence order provide certain prevention treatment ideas for clinical reduction CPSP.Patients radical...
Propofol can have adverse effects on developing neurons, leading to cognitive disorders, but the mechanism of such an effect remains elusive. Here, we aimed investigate propofol neuronal development in zebrafish and identify molecular mechanism(s) involved this pathway. The was demonstrated by a series vitro vivo experiments. mRNA injections, whole-mount situ hybridization immunohistochemistry, quantitative real-time polymerase chain reaction, terminal deoxynucleotidyl transferase-mediated...
Abstract Although regulation of the blood glucose level is a common therapy for Type 2 diabetes mellitus (T2DM), root cause this disease (such as damage pancreatic β cells) cannot be solved. Remodeling microenvironment and gut microbial homeostasis to improve cells dysfunction become potential strategy but remains challenging. Herein, curcumin (CUR) bifidobacterial (BI) co‐delivery system based on self‐emulsifying technology (CUR‐BI‐SEDDS), which can generate protective self‐assembled...