A5100754219- Traditional Chinese Medicine Analysis
- Nitric Oxide and Endothelin Effects
- Sperm and Testicular Function
- Traditional Chinese Medicine Studies
- Saffron Plant Research Studies
- Cancer-related molecular mechanisms research
- Medical Research and Treatments
- Antibiotic Resistance in Bacteria
- Neonatal Health and Biochemistry
- Antibiotics Pharmacokinetics and Efficacy
- Visual perception and processing mechanisms
- Birth, Development, and Health
- Alcohol Consumption and Health Effects
- Food Quality and Safety Studies
- Advanced Drug Delivery Systems
- Cardiac Arrest and Resuscitation
- Reproductive Biology and Fertility
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Ocular Surface and Contact Lens
- Phytochemistry and biological activity of medicinal plants
- Ophthalmology and Visual Impairment Studies
- Pregnancy and preeclampsia studies
- Renin-Angiotensin System Studies
- Biological and pharmacological studies of plants
Guangdong Pharmaceutical University
2024
Beijing Radiation Center
2024
Sun Yat-sen University
2024
Union Hospital
2024
Jiangsu Agri-animal Husbandry Vocational College
2020-2024
Fujian Medical University
2022-2024
Putian University
2009-2023
Southern Medical University
2023
Boai Hospital of Zhongshan
2023
Fuzhou Maternity and Child Health Care Hospital
2022
Abstract EVA1A (also known as transmembrane protein 166) is a involved in the regulation of autophagy that acts an adaptor to recruit or bind proteins lysosome endoplasmic reticulum. In present study, we identified target microRNA-125b (miR-125b), member highly conserved family miRNAs has been proposed biomarker for hepatocellular carcinoma (HCC). Analysis oxaliplatin-sensitive and oxaliplatin-resistant HCC cell lines showed miR-125b downregulated resistant cells its overexpression sensitive...
Abstract Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase belonging to class III histone deacetylases. Previous studies have shown that SIRT1 involved in kidney physiology regulation and protects the from various pathological factors. However, underlying mechanisms behind its function yet be fully elucidated. In our study, we found ablation of Sirt1 renal interstitial cells resulted more severe damage fibrosis unilateral ureteral obstruction (UUO) model...
Left ventricular remodeling commonly complicates end-stage renal disease following chronic kidney (CKD). This study investigated the therapeutic efficacy of resveratrol (RSV), a polyphenolic compound, on left in subtotal nephrectomy rats and sought to uncover underlying molecular mechanisms. Subtotal caused dysfunction, such as gradual increases serum creatinine blood urea nitrogen, glomerular sclerosis, tubulointerstitial fibrosis. In addition, also resulted significant myocyte...
Although effective amblyopia treatments are available, treatment outcome is unpredictable, and the condition recurs in up to 25% of patients. We aimed evaluate whether a large-scale quantitative contrast sensitivity function (CSF) data source, coupled with machine learning (ML) algorithms, can predict response recurrence individuals.
Abstract Cardiovascular and renal inflammation induced by Aldosterone (Aldo) plays a pivotal role in the pathogenesis of hypertension fibrosis. GSK‐3β contributes to inflammatory cardiovascular diseases, but its Aldo‐induced hypertension, damage is not clear. In present study, rats were treated with Aldo combined SB‐216763 (a inhibitor) for 4 weeks. Hemodynamic, cardiac, parameters assayed at indicated time. Here we found that presented cardiac hypertrophy dysfunction. Cardiac expression...
Introduction: Exercise is recommended for patients undergoing hemodialysis to decrease morbidity and mortality. However, their exercise level lower than healthy people. Understanding reasons behind sedentary lifestyle required. Traditional Chinese culture may have a profound impact on patients’ perceptions of exercise, particularly with regard the relationship overwork kidney function family members’ attitudes toward participation in exercise. Therefore, we sought explore facilitators...
Purpose: Dry eye disorders are a major health care burden. We previously reported the identification of N-methyl-N-phenyl-6-(2,2,3,3-tetrafluoropropoxy)-1,3,5-triazine-2,4-diamine [cystic fibrosis transmembrane conductance regulator (CFTR)act-K267], which activated human wild-type CFTR chloride with EC50 ∼ 30 nM. Here, we report in vivo evidence for CFTRact-K267 efficacy an experimental mouse model dry using compatible ophthalmic vehicle. Methods: activation mice was demonstrated by ocular...
Despite recent advances, chronic heart failure remains a significant and growing unmet medical need, reaching epidemic proportions carrying substantial morbidity, mortality, costs. A safe convenient therapeutic agent that produces sustained inotropic effects could ameliorate symptoms, improve functional capacity quality of life. We discovered small amounts 2-deoxy-ATP (dATP) activate cardiac myosin leading to enhanced contractility in normal failing muscle. Cardiac activation triggers faster...
Abstract Background Hyperbilirubinemia is one of the common complications after cardiac surgery and associated with increased mortality. However, to best our knowledge, reports on clinical significance postoperative severe hyperbilirubinemia in Stanford type A aortic dissection (AAD) patients were limited. Methods Patients who underwent surgical treatment for AAD center between January 2015 December 2018 retrospectively screened. In-hospital mortality, long-term acute kidney injury (AKI),...
Increasing evidence indicates that transforming growth factor-β1 (TGF-β1) is a pivotal mediator in the pathogenesis of renal fibrosis. Mesangial cells (MCs) are important for glomerular function under both physiological and pathological conditions. Studies have found expression level prostaglandin E2 (PGE2) MCs increases high glucose conditions, PGE2 affects proliferation hypertrophy mainly through EP1 pathway, accumulation extracellular matrix main events leading to In this study, we...
Abstract Background Hyperbilirubinemia after heart valve surgery (HVS) with cardiopulmonary bypass is frequently observed and associated worse outcomes. We investigated the characteristics prognosis of patients severe hyperbilirubinemia HVS for rheumatic disease (RHD) to identify clinical outcomes potential risk factors. Methods Between 2015 2018, who underwent in cardiac intensive care unit our hospital were retrospectively screened. Risk factors acute kidney injury (AKI), requirement...
Background: Several observational studies have demonstrated that significantly rising circulating adipokine levels are pervasive in preeclampsia or eclampsia disorder (or toxemia (PET)). However, it remains unclear whether this relationship is causal. In study, we sought to elucidate the causal effects of on PET. Methods: Summary-level data and independent genetic variants strongly associated with common molecule (adiponectin, leptin, resistin, sOB-R, PAI-1) were drawn from public...
Introduction: Cefquinome sulfate (CS) is the first fourth-generation antibiotic for animals, which has a wide antibacterial spectrum, strong activity and low drug resistance. However, it accompanied by problems of poor therapeutic efficacy. In this context, use nanosuspensions have been found to be an attractive strategy. The main objective work develop new oily nanosuspension improve bioavailability stability CS formulations. Methods: After screening formulations, cefquinome (CS-NSP) was...
Background: The pathogenesis of patellar tendon fibrosis caused by overuse remains unclear. In an effort to further investigate effective treatments for attributed overuse, it is necessary construct a reliable animal model. Purpose: A rabbit model was developed with the use electrical stimulation induce jumping. and development were subsequently investigated this Study Design: Controlled laboratory study. Methods: total 32 New Zealand White rabbits randomly divided into jumping group control...
COVID-19’s global spread had numerous negative consequences for the industry. At present, many antivirus products and technologies have been proposed, among which ultraviolet has proven effective does not pollute environment. Most disinfection devices use fixed-point methods disinfection, is very labor-intensive inflexible. Mobile robots are often optimized because movement trajectory of robot optimized, resulting in insufficient areas. This study proposes a heuristic self-optimizing path...