A5084537221- Ophthalmology and Visual Impairment Studies
- Visual perception and processing mechanisms
- Glaucoma and retinal disorders
- Vestibular and auditory disorders
- Ophthalmology and Eye Disorders
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Child Development and Digital Technology
- Plant and animal studies
- Corneal surgery and disorders
- Spatial Neglect and Hemispheric Dysfunction
- Impact of Technology on Adolescents
- Ocular and Laser Science Research
- Corrosion Behavior and Inhibition
- Tactile and Sensory Interactions
- Pharmaceutical and Antibiotic Environmental Impacts
- Hearing, Cochlea, Tinnitus, Genetics
- Retinopathy of Prematurity Studies
- Ginger and Zingiberaceae research
- Magnesium Alloys: Properties and Applications
- Pituitary Gland Disorders and Treatments
- Hearing Loss and Rehabilitation
- Toxoplasma gondii Research Studies
- Magnesium Oxide Properties and Applications
- Retinal Imaging and Analysis
Sun Yat-sen University
2016-2025
Guangzhou Center for Disease Control and Prevention
2024-2025
Xichang University
2024
Xinjiang Agricultural University
2024
Purpose: The purpose of this study was to investigate the relationship between fixation stability deficits in anisometropic amblyopia and various visual functions, as well underlying retinal structure. Methods: All 164 patients with were recruited cross-sectional study. contrast sensitivity function (CSF) measured using qCSF method, whereas MP-3 microperimeter used assess locate preferred locus. Bivariate contour ellipse area (BCEA) both amblyopic fellow eyes dependent variable. Based on...
Abstract Amblyopia is a neurodevelopmental disorder of vision that occurs when the visual cortex receives decorrelated inputs from two eyes during an early critical period development. Amblyopic are subject to suppression fellow eye, generate weaker evoked potentials (VEPs) than and have multiple deficits including impairments in acuity contrast sensitivity. Primate models human psychophysics indicate stronger associated with greater amblyopic eye sensitivity acuity. We tested whether...
To assess whether monocular contrast sensitivity and stereoacuity impairments remain when visual acuity is fully recovered in children with refractive amblyopia.A retrospective review of 487 patients diagnosed amblyopia whose improved to 0.08 logMAR or better both eyes following optical treatment was conducted. Measurements had been made normalized. All treated correction for approximately 2 years diagnosis. No other treatments were provided. Monocular measured using the CSV-1000E chart 6...
This study explored the efficacy and predictors of success for a novel monocular fine orientation discrimination perceptual learning (fine-PL) approach in addressing deficits meridional amblyopia (MA). Prospective, longitudinal study. Fifty-three children with persistent MA participated this Twenty-one participants underwent 14-day regimen fine-PL focused on grating exercise (±5°) aligned vertical or horizontal meridian near each individual's threshold spatial frequencies. Nineteen coarse...
The risk factors for mobile phone dependence (MPD) remain inconsistent and debated in the literature. Previous studies China reported MPD prevalence rates of 26.2% among junior high students 27.9% senior 2012. A 2021 study Guangzhou City found a 13.5% first-year students. This reveals that overall middle school was 10.0% 2023, with distinct between (7.3%) (12.4%) research identifies key development documents injury patterns associated excessive use. These findings provide an evidence base...
Re-establishing normal binocular visual processing is the key to amblyopia recovery beyond critical period of development. Here, by combining perceptual learning, behavioral testing, and steady-state visually evoked potentials (SSVEPs), we examined how monocular learning in amblyopic eye could change adolescent adult system. We found that training reduced interocular difference between fellow eyes increased amplitude a SSVEP component, with significant negative correlation two measures. Our...
Perceptual learning in contrast detection improves monocular visual function adults with anisometropic amblyopia; however, its effect on binocular combination remains unknown. Given that the amblyopic system suffers from pronounced functional loss, it is important to address how responds such training strategies under viewing conditions. Anisometropic amblyopes (n = 13) were asked complete two psychophysical supra-threshold summation tasks: (1) phase and (2) dichoptic global motion coherence...
Monocular perceptual learning has shown promising performance in restoring visual function amblyopes beyond the critical period laboratory. However, treatment outcome is variable and indeterminate actual clinical neuroscientific practice. We aimed to explore efficacy of monocular setting. By combining continuous monitoring measurements, we evaluated characteristics acuity contrast sensitivity improvement further explored individualized effect after learning. Amblyopes (average age:17 ± 7...
Purpose.: Amblyopia is a developmental abnormality of visual cortex characterized by spatial processing deficits. Recently, it has been suggested that temporal also affected. We investigated sensitivity measuring synchrony sensitivity. Methods.: In Experiment 1, we used contrast detection task to compare the flickering 3 Hz Gaussian blob discrimination for 180° phase shift. 2, measured thresholds directly assessing minimum degree asynchrony allowed subjects discriminate which 4 high-contrast...
Purpose: To explore whether subtle changes in visual quality can be detected using different measures of function against the quick contrast sensitivity test (quick CSF). Methods: Sixty participants, aged 17 to 34 years, were enrolled. Participants' vision was degraded by 0.25 D undercorrection (0.25 D), 60% neutral density filter brightness reduction (60% ND), and 0.8 Bangerter foil optical diffusion (0.8BAN). Visual tests including acuity (CSV-1000E CSF) measured with participant's...
PurposeTo explore the association between cause of amblyopia and pre-treatment contrast sensitivity, stereoacuity, fixation nystagmus.DesignRetrospective cohort study.MethodsA retrospective review was conducted for 3408 patients with who had not yet started treatment utilizing a large patient database maintained at Zhongshan Ophthalmic Centre. Six amblyogenic factor subtypes were identified: anisometropia, isoametropia, strabismus, anisometropia monocular visual deprivation, binocular...
Although effective amblyopia treatments are available, treatment outcome is unpredictable, and the condition recurs in up to 25% of patients. We aimed evaluate whether a large-scale quantitative contrast sensitivity function (CSF) data source, coupled with machine learning (ML) algorithms, can predict response recurrence individuals.
We have recently described a rapid technique for measuring suppression using dichoptic signal/noise task. Here, we report modification of this that allows accurate measurements to be made in amblyopic patients with high levels anisometropia. This was necessary because aniseikonic image size differences between the two eyes can provide cue segregation and, therefore, influence measurement these patients.Suppression measured our original and modified whereby signal noise elements randomized...
BackgroundChildren with deprivation amblyopia due to childhood cataract have been excluded from much of the emerging research into treatment. An investigation was conducted determine whether contrast‐balanced binocular treatment – a strategy currently being explored for children anisometropic and strabismic may be effective in amblyopia.MethodsAn unmasked, case‐series design intended assess proof principle employed. Eighteen cataracts (early bilateral n = 7, early unilateral developmental...
Limbal dermoid (LD) is a congenital ocular tumor that causes amblyopia and damages visual acuity (VA) function. This study evaluated the therapeutic efficacy of perceptual learning (PL) toward improving contrast sensitivity function (CSF) VA. A total 25 children with LD normal were compared in terms CSF The group was further randomly allocated into two arms: nine underwent PL combined patching eight only; patients quit treatment. primary outcome area under log (AULCSF), secondary best...
Amblyopia is the most common cause of unilateral visual impairment in children and requires long-term treatment. This study aimed to quantify impact pandemic control measures on amblyopia management.This was a retrospective cohort data from large management database at major tertiary eye care centre China.Outpatients with who visited hospital 1 June 2019, through 28 February 2022.The primary outcome number first follow-up in-person visits for Secondary outcomes included time interval between...
Purpose: Perceptual learning (PL) has shown promising performance in restoring visual function adolescent amblyopes. We retrospectively compared the effect of a well-accepted PL paradigm on patients with anisometropic amblyopia or without patching therapy history (patching [PT] group versus no [NPT] group). Methods: Eighteen PT and 13 NPT underwent monocular for 3 months. During training, practiced Gabor detection task following lateral masking by applying temporal two-alternative forced...
To assess the outcomes of posterior chamber implantable collamer lens (ICL) implantation in Chinese pediatric patients with unilateral high myopic amblyopia.Eleven eyes 11 amblyopic aged 11.02±3.34y underwent ICL (model V4, Staar Surgical Inc.) to treat anisometropia were studied. Visual acuity, cycloplegic refraction, contrast sensitivity, stereopsis, intraocular pressure (IOP), vaulting, corneal endothelial cell count and complications evaluated. Patients completed follow-up at 3d, 1, 3mo...
We investigate the efficacy of a novel dichoptic mapping paradigm in evaluating visual function anisometropic amblyopes.Using standard clinical measures (visual acuity, stereo Bagolini lenses, and neutral density filters) quantitative technique, 26 patients with amblyopia (mean age = 19.15 ± 4.42 years) were assessed. Two additional psychophysical interocular suppression measurements tested global motion coherence binocular phase combination tasks. Luminance reduction was achieved by placing...
Limbal stem cells are essential for continuous corneal regeneration and injury repair. METTL3-catalyzed N6-methyladenosine (m6A) mRNA modifications involved in many biological processes play a specific role cell regeneration, while the of m6A repair remains unknown. In this study, we generated limbal cell-specific METTL3 knockout mouse model studied repairing caused by alkali burn. The results showed that promotes vivo proliferation migration, leading to fast injury. addition, modification...