A5022437604- Syphilis Diagnosis and Treatment
- HIV Research and Treatment
- Tea Polyphenols and Effects
- Physical Activity and Health
- Lung Cancer Treatments and Mutations
- Viral Infections and Vectors
- Tannin, Tannase and Anticancer Activities
- Cancer therapeutics and mechanisms
- Carcinogens and Genotoxicity Assessment
- Respiratory viral infections research
- Cardiac Health and Mental Health
- Nutrition, Genetics, and Disease
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Reproductive tract infections research
- HIV, Drug Use, Sexual Risk
- Radioactivity and Radon Measurements
- Health, psychology, and well-being
- Microbial infections and disease research
- Cervical Cancer and HPV Research
- HIV/AIDS Research and Interventions
- Esophageal Cancer Research and Treatment
- Effects and risks of endocrine disrupting chemicals
- COVID-19 Impact on Reproduction
- Sleep and related disorders
University of South China
2024-2025
Yunnan Agricultural University
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Shenyang Agricultural University
2024
National Clinical Research
2023
National Kaohsiung University of Science and Technology
2022
Yale University
2022
Yunnan Center for Disease Control And Prevention
2020-2021
Kunming University
2020
ABSTRACT Mycoplasma pneumoniae (Mp), a unique pathogen devoid of cell wall, is naturally impervious to penicillin antibiotics. This bacterium the causative agent M. pneumonia, an acute pulmonary affliction marked by interstitial lung damage. Non-macrolide medications may have potential adverse effects on developmental trajectory children, thereby establishing macrolides as preferred treatment for in pediatric patients. However, emergence macrolide-resistant and multidrug-resistant strains...
Triple-negative breast cancer is a clinically aggressive malignancy with poorer outcomes versus other subtypes of cancer. Numerous reports have discussed the use epigallocatechin-3-gallate (EGCG) against various types However, effectiveness EGCG limited by its high oxidation and instability. The Notch pathway critical in development prognosis, inhibition potential treatment strategy. In this study, we investigated effects prodelphinidin B-2,3,3''-O-gallate (named PB2,3,3''/OG or compound 2)...
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. The inhibition epidermal growth factor receptor (EGFR) signaling by tyrosine kinase inhibitors or monoclonal antibodies plays a key role in NSCLC treatment. Unfortunately, these treatment strategies are limited eventual resistance and cell lines with differential EGFR status. Therefore, new therapeutic for urgently required.To improve stability absorption (-)-epigallocatechin-3-gallate (EGCG), we...
Cancer is a major public health issue that seriously endangers the and social development of China. Future initiatives for cancer prevention control should continue to adhere principle prioritizing prevention, comprehensively implement related activities nationwide. This critical reducing burden in Chinese residents, especially low- middle-income populations those living areas are less economically developed. In past several decades, international community has significantly reduced...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, and commonly associated with activating mutations in the Notch1 pathway. (-)-Epigallocatechin-3-gallate (EGCG) most abundant active catechin has been shown to regulate Notch signaling. Taking into account highly oxidizable unstable of EGCG, we proposed that EGCG oxides may have greater potential signaling than EGCG. In this study, isolated identified (compound 2-4), using a chemical oxidation strategy,...
The associations between multiple sleep characteristics and smoking behavior are inconsistent, it is unclear which most crucial for tobacco prevention. This study aimed to explore the status/intensity identify potential core domain of smoking-related using network analysis. Data were obtained from a survey cancer-related risk factors among Chinese adults. Logistic regression models used quantify status/intensity. Network analyses employed characteristics. A total 5,228 participants with...
Epidermal growth factor receptor (EGFR)-activating mutations are critical factors in the development of EGFR-driven non-small-cell lung cancer (NSCLC), and molecular targeted therapies have focused on inhibiting these mutations. EGFR tyrosine kinase inhibitors (TKIs) remarkable inhibitory effects NSCLC with However, acquired resistance limits clinical application EGFR-TKIs, highlighting need for discovery novel therapeutic strategies. 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone is a natural...
The 2-hydroxy-4-(methylthio) butanoic acid isopropyl ester (HMBi), a rumen protective methionine, has been extensively studied in dairy cows and beef cattle shown to regulate gastrointestinal microbiota improve production performance. However, knowledge of the application HMBi on cashmere goats simultaneous study hindgut is still limited. In this study, supplementation increased concentration total serum protein, microbial protein feces, as well butyrate feces. results PCoA PERMANOVA showed...
Non-small cell lung cancer (NSCLC) harboring activating EGFR mutations were initially treated by first-generation tyrosine kinase inhibitors (EGFR-TKIs), unfortunately, the efficacy of these drugs is limited, mostly frequent due to T790M mutation.Although osimertinib has been approved treat patients with T790M-positive NSCLC, majority will develop C797S mutation and suffer diseases again.Therefore, more novel therapeutic strategies for mutation-positive NSCLC are urgently required.We...
This study aimed to provide a detailed analysis of the temporal trends cancer incidence rates for individuals aged 0-19 years in selected regions globally from 1978 2012.
Abstract Background Kidney cancer originates from the urinary tubule epithelial system of renal parenchyma, accounting for 20% all tumors. Approximately 70% cases are localized at diagnosis, and 30% metastatic. Most kidney cancers can be cured by surgery, but most metastatic patients relapse after surgery eventually die cancer. Therefore, accurately predicting patient survival identifying high‐risk will effectively guide interventions improve prognosis. Methods This study used data 12,394...
Non-small-cell lung cancer is one of the principal causes cancer-related death around world. Chemotherapy commonly used to treat wild type epidermal growth factor receptor non-small-cell cancer. (-)-Epigallocatechin-3-gallate most abundant and active catechin. However, (-)-epigallocatechin-3-gallate has limited clinical application due its poor stability absorption. Herein, we report that a glycosylated azide undergoes click reaction with terminal alkyne yield triazole-linked...
Objective: To analyze the characteristics of HIV-1 molecular network in men who have sex with (MSM) from 2016 to 2018 Kunming, Yunnan province, explore risk factors associated transmission and provide evidence for effective implementation intervention. Methods: A total 540 samples newly reported positive MSM were consecutively collected Kunming 2018, pol gene fragments amplified by nested polymerase chain reaction (PCR). networks constructed according bootstrap value maximum likelihood...
To evaluate the cost-effectiveness of typical pharmaceutical smoking cessation intervention strategies in China context primary cancer prevention.
is a specialized intracellular parasitic pathogen capable of causing pneumonia, sinusitis, bronchitis, and other respiratory diseases, which pose significant public health challenges. Therefore, rapid, accurate, sensitive diagnosis crucial for the prevention treatment diseases caused by
Syphilis is a persistent sexually transmitted disease caused by Treponema pallidum subsp. pallidum, dense spirochete. Severe multi-organ failure often observed in late-stage infections. T. exerts cytotoxic effects vitro cultures and acts pathogenic via the production of toxic substances. Cytolysin (tly), which damages target cells, plays key role pathogenicity lysogenic cytotoxins. Cell damage mainly three toxins: pore-forming toxins, phospholipases (lipasic toxins), surface-active toxins....
Epidermal growth factor receptor (EGFR)-activating mutations are critical factors in EGFR-driven nonsmall cell lung cancer (NSCLC) development, and molecular targeted therapies have focused on inhibiting these mutations.EGFR tyrosine kinase inhibitors (TKIs) remarkable inhibitory effect for NSCLC with EGFR mutations.However, acquired resistance limited the clinical application of EGFR-TKIs, which highlights need discovery novel inhibitors.In this study, we created Ba/F3 cells harboring...