A5101945012- Cancer-related molecular mechanisms research
- Atrial Fibrillation Management and Outcomes
- MicroRNA in disease regulation
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Cancer, Hypoxia, and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Circular RNAs in diseases
- Acute Ischemic Stroke Management
- Cardiovascular Syncope and Autonomic Disorders
- Antimicrobial Resistance in Staphylococcus
- RNA Research and Splicing
- Heme Oxygenase-1 and Carbon Monoxide
- Ovarian function and disorders
- Aquaculture disease management and microbiota
- Cardiac Arrhythmias and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Reproductive Biology and Fertility
- Cardiovascular and Diving-Related Complications
- Vibrio bacteria research studies
- Signaling Pathways in Disease
- RNA modifications and cancer
- Obstructive Sleep Apnea Research
Ningbo Institute of Industrial Technology
2024
Chinese Academy of Sciences
2024
Children's Hospital of Zhejiang University
2018-2024
Shengli Oilfield Central Hospital
2019-2024
Affiliated Hospital of Qingdao University
2016-2024
Qingdao University
2016-2024
Tianjin University of Traditional Chinese Medicine
2024
Weatherford College
2024
Xuzhou Medical College
2020-2023
Shanghai Ocean University
2023
Abstract Kidney renal clear cell carcinoma (KIRC) is the most common (RCC). However, patients with KIRC usually have poor prognosis due to limited biomarkers for early detection and prediction. In this study, we analysed key genes pathways involved in from an array dataset including 26 tumour adjacent normal tissue samples. Weighted gene co-expression network analysis (WGCNA) was performed WGCNA package, 20 modules were characterized as having highest correlation KIRC. The upregulated...
Oral gene therapy has emerged as a potential optimal treatment for ulcerative colitis (UC). Nucleic acid drugs possessing versatility can not only inhibit inflammation but realize colon mucosal healing, fulfilling the clinical objective of UC therapy. However, effective accumulation and distribution oral nucleic in remain considerable challenge. Furthermore, current delivery systems pay more attention to colon, while which plays key role treatment, never catches researchers. Here, we used...
ObjectiveTo investigate the antiapoptosis effect of sphingosine-1-phosphate (S1P) on human fetal ovarian tissue treated by cyclophosphamide (CTX).DesignExperimental animal study.SettingUniversity center for reproductive medicine and IVF unit.Animal(s)Female immunodeficient BALB/c nude mice, 6 to 8 weeks old.Intervention(s)Human slowly cryopreserved then subcutaneously transplanted in mice.Main Outcome Measure(s)Follicle survival assessed qualitatively quantitatively using H&E staining,...
Accumulating evidence shows that tRNA-derived fragments are a novel class of functional small non-coding RNA; however, their roles in aortic dissection (AD) still unknown. In this study, we found 5′-tiRNA-Cys-GCA was significantly downregulated human and mouse models dissection. The abnormal proliferation, migration, phenotypic transition vascular smooth muscle cells (VSMCs) played crucial role the initiation progression dissection, with as potential switching regulator, because its...
// Liyuan Guo 1 , Yan Peng 2 Yuanyuan Meng Yunduo Liu Shangshang Yang Hong Jin and Qi Li Gynecological Cancer Department, Harbin Medical University Hospital, 150081, China Disease Prevention Center, First Affiliated Hospital of Heilongjiang Chinese Traditional Medicine, 150040, Correspondence to: Li, email: qijarali@163.com Keywords: BRCA1/2, ovarian cancer, microRNA, long non-coding RNA, prognosis Received: June 08, 2017     Accepted: 28, Published: July 26, 2017...
To explore an optimal model to predict the response of patients with axillary lymph node (ALN) positive breast cancer neoadjuvant chemotherapy (NAC) machine learning using clinical and ultrasound-based radiomic features.In this study, 1014 ALN-positive confirmed by histological examination received preoperative NAC in Affiliated Hospital Qingdao University (QUH) Municipal (QMH) were included. Finally, 444 participants from QUH divided into training cohort (n = 310) validation 134) based on...
Abstract This study was intended to analyze effects of lncRNA CRNDE on cervical cancer cell growth and metastasis. Fifty pairs tissues corresponding adjacent were collected. Expressions long non-coding RNAs (lncRNAs) in tissue samples detected by microarray analysis. Expression levels cells normal qRT-PCR. Cell-counting kit-8 (CCK-8) assay clone formation utilized evaluate growth. Wound healing Transwell conducted detect the migratory invasive capability cells. The expressions higher than...
Cassia semen (Cs), a seed of obtusifolia L. (Leguminosae), is popular functional beverage. Previous studies reported that Cs displayed antioxidant, antifungal and strong liver protective effects.This study evaluates the hepatoprotective effects on non-alcoholic fatty disease (NAFLD).Seventy-two male Wistar rats raised with high-fat diet (HFD) were randomly allotted into model, metformin (0.2 g/kg) (0.5, 1, 2 g/kg)-treated groups. Another 12 normal feed as control group; all orally...
Abstract Research on mixed Sn‐Pb perovskite solar cells (PSCs) is gaining significant attention due to their potential for high efficiency in all‐perovskite tandem cells. However, Sn 2+ susceptible oxidation, leading a defect density. The oxidation primarily occurs through two pathways: one involving reaction with oxygen, and the other related iodine defects, which generate I 2 further accelerate of ⁺, greatly reducing stability. First, tackle photo‐stability issues caused by amber acid (AA)...
Abstract In the female reproductive tract, endometrial cancer is most common malignant tumor. Recently, specific functions of many miRNAs have been identified in cancer. However, contradictory effects microRNA‐373 (miR‐373) different human cancers draw our attention. present research, upregulation miR‐373 was which predicted poor prognosis. Moreover, promoted migration, invasion, and proliferation cells. To further confirm that results, EMT Wnt/β‐Catenin pathways were also investigated, by...
The myocardial wall of the left ventricle is a complex, multilayered structure and not homogenous. aim this study was to determine longitudinal strain (LS) in three layers normal pregnant women according gestation proceedings.The advanced two-dimensional speckle tracking echocardiography (2D STE) performed on 62 during each pregnancy trimester 6 9 weeks after delivery, while 30 age-matched, healthy, nonpregnant served as controls. LS endocardial, mid-myocardial epicardial at 18 cardiac...
Obstructive sleep apnea syndrome (OSAS) is the most common type of disorder which associated with a series cardiovascular disorders, including right ventricular (RV) dysfunction. However, it difficult to assess RV function systematically using conventional echocardiography because has complex geometrical shape. A case-control study was performed regional potential dysfunction in patients OSAS velocity vector imaging (VVI) from March 2014 October 2015. Sixty-nine were divided into 3 groups:...
To quantitatively investigate the impact of left atrial geometric remodeling on fibrillation recurrence after catheter ablation.A retrospective analysis 105 patients with who underwent coronary computed tomographic angiography before ablation. Risk factors for were identified by multivariable logistic regression and used to create a nomogram.After at least 12 months follow-up, 30 (29%) developed recurrent fibrillation. Patients had higher volume, sphericity, lower ejection fraction (LAEF) (P...
BACKGROUND The aim of this study was to determine whether poor collaterals contribute the occurrence certain types cognitive disorders in asymptomatic middle cerebral artery stenosis (MCAS). MATERIAL AND METHODS Patients aged ≥45 years with MCAS confirmed by computed tomography angiography were included a single-center retrospective study. They did not have prior stroke or dementia. Within 7 days admission, MRI and comprehensive neuropsychological assessment performed. Cognitive conducted...
The two-component system VraSR responds to the cell wall-active antibiotic stress in Staphylococcus epidermidis. To study its regulatory function biofilm formation, a vraSR deletion mutant (ΔvraSR) was constructed using S. epidermidis strain 1457 (SE1457) as parent strain. Compared SE1457, ΔvraSR showed impaired formation both vitro and vivo with higher ratio of dead cells within biofilm. Consistently, produced much less polysaccharide intercellular adhesin (PIA). also increased...
This study aims to evaluate the relationship between pericoronary fat attenuation index (FAI), derived from coronary artery computed tomography angiography, and post-lipid management levels of low-density lipoprotein cholesterol in patients with disease (CAD). Additionally, investigates inflammation across different lipid strategies.
We investigated the correlation of orthostatic hypotension (OH) in Parkinson disease (PD) with course and severity, its possible impact on quality life. 171 PD patients were recruited divided into PD-NOH (n = 91) PD-OH groups 80). Clinical data collected. The severity life evaluated. was analyzed using logistic regression analysis. ROC curve plotted. There significant differences ( P < .05) between terms course, non-motor symptoms (somnipathy), Hoehn&Yahr stage, LEDD score, RBDSQ...
Abstract Uncontrolled traumatic hemorrhage is a leading cause of preventable death. As two main forms hemostatic materials, however, both sponges and hydrogel adhesives usually fail to control massive due their respective shortcomings. Hemostatic sponge shows weak tissue adhesion, while the gelation process makes it difficult seal high‐pressure bleeding wounds. There an urgent need develop next‐generation hemostats combining advantages adhesives. Herein, general methodology prepare novel Fe...