A5036274809- Asymmetric Synthesis and Catalysis
- Axial and Atropisomeric Chirality Synthesis
- Antibiotic Resistance in Bacteria
- Alkaloids: synthesis and pharmacology
- Molecular spectroscopy and chirality
- Synthesis of Indole Derivatives
- Myasthenia Gravis and Thymoma
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Antibiotics Pharmacokinetics and Efficacy
- Synthesis and Catalytic Reactions
- Inflammasome and immune disorders
- Vibrio bacteria research studies
- Peripheral Neuropathies and Disorders
- MicroRNA in disease regulation
- Antifungal resistance and susceptibility
- Enterobacteriaceae and Cronobacter Research
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Autophagy in Disease and Therapy
- Multiple Sclerosis Research Studies
- Bacterial Identification and Susceptibility Testing
- Cardiac Valve Diseases and Treatments
- Parkinson's Disease and Spinal Disorders
- Supramolecular Chemistry and Complexes
Xuzhou Medical College
2016-2024
Xiangya Hospital Central South University
2021-2024
Central South University
2021-2024
Southern University of Science and Technology
2021-2024
Jiangsu Normal University
2014-2024
University of Pennsylvania
2024
China Academy of Engineering Physics
2024
People’s Hospital of Wenshan Prefecture
2024
Affiliated Hospital of Xuzhou Medical College
2022
University of Hong Kong
2021
Indole-based chiral heterocycles constitute a class of important heterocyclic compounds that are found in numerous pharmaceuticals, functional materials, and catalysts or ligands. Catalytic asymmetric synthesis, for which the 2001 Nobel Prize Chemistry was awarded, has been demonstrated to be most efficient method accessing compounds. Therefore, catalytic synthesis indole-based attracted great interest from scientific community. However, strategies toward this goal rather limited, challenges...
Abstract The first catalytic asymmetric construction of 3,3′‐bisindole skeletons bearing both axial and central chirality has been established by organocatalytic addition reactions 2‐substituted 3,3′‐bisindoles with 3‐indolylmethanols (up to 98 % yield, all >95:5 d.r., >99 ee ). This reaction also represents the highly enantioselective axially chiral skeletons, utilizes strategy introducing a bulky group ortho ‐position prochiral 3,3′‐bisindoles. not only provides good example for...
Abstract The organocatalytic asymmetric arylative dearomatization of indoles was achieved through two tandem approaches involving 2,3‐disubstituted and quinone imine ketals. One approach utilized the enantioselective cascade 1,4 addition/alcohol elimination reaction, other employed one‐pot dearomatization/transfer hydrogenation sequence. In both cases, enantiomerically pure indole derivatives that bear an all‐carbon quaternary stereogenic center were generated in high yields excellent...
The development of (4 + 3) cyclizations vinyl aziridines, especially catalytic asymmetric versions, is needed in organic synthesis. This report describes an iridium-catalyzed cyclization aziridines with para-quinone methide (p-QM) derivatives, and this reaction constructs a seven-membered benzoxazepine scaffold moderate to high yields (40% 96%) considerable diastereoselectivities (70:30 dr >95:5 dr). Moreover, the version accomplished presence palladium catalyst chiral ligand, modification...
Catalyst-controlled chemoselective and enantioselective reactions of tryptophols with isatin-derived imines were demonstrated. Under catalysis a chiral phosphoric acid, diastereoselective dearomative cyclization occurred, while, in the presence squaramide-tertiary amine, addition occurred. Both afforded 3-substituted 3-amino-oxindoles generally good yields (up to 99%) excellent stereoselectivities >95:5 dr, 99:1 er).
Deuterium/Tritium (D/T) handling in defined proportions are pivotal to maintain steady-state operation for fusion reactors. However, the hydrogen isotope effect metal-hydrogen systems always disturbs precise D/T ratio control. Here, we reveal dominance of kinetic during desorption. To reconcile thermodynamic stability and effect, demonstrate a quantitative indicator T
Abstract The organocatalytic asymmetric arylative dearomatization of indoles was achieved through two tandem approaches involving 2,3‐disubstituted and quinone imine ketals. One approach utilized the enantioselective cascade 1,4 addition/alcohol elimination reaction, other employed one‐pot dearomatization/transfer hydrogenation sequence. In both cases, enantiomerically pure indole derivatives that bear an all‐carbon quaternary stereogenic center were generated in high yields excellent...
An organocatalytic [4 + 1] cyclization of o-QMs with MBH carbonates has been established using naphthylindole-derived phosphine (NIP) as an organocatalyst. By this approach, a series 2,3-dihydrobenzofuran derivatives have synthesized in high yields and excellent diastereoselectivities (up to 99% yield, >95:5 dr). This reaction not only the first but also represents application phosphines organocatalysts catalytic reactions. In addition, provided useful method for constructing scaffolds.
The continuous emergence of carbapenem-resistant Escherichia coli (CRECO) presents a great challenge to public health. New Delhi metallo-lactamase (NDM) variants are widely disseminated in China, so the research on prevalence and transmission diverse blaNDM is urgently needed. In present study, 54 CRECO isolates were collected from 1,185 five hospitals Northern Jiangsu Province, China September 2015 August 2016. Antimicrobial susceptibility tests, PCR detection resistance determinants,...
Abstract The first catalytic asymmetric construction of 3,3′‐bisindole skeletons bearing both axial and central chirality has been established by organocatalytic addition reactions 2‐substituted 3,3′‐bisindoles with 3‐indolylmethanols (up to 98 % yield, all >95:5 d.r., >99 ee ). This reaction also represents the highly enantioselective axially chiral skeletons, utilizes strategy introducing a bulky group ortho ‐position prochiral 3,3′‐bisindoles. not only provides good example for...
The objective of this study was to examine the impact and underlying mechanisms pelargonidin-3-galactoside (Pg3gal) produced from purple sweet potatoes on colonic inflammation induced by dextran sulfate sodium (DSS) in a murine model ulcerative colitis (UC). C57BL/6J mice were categorized into four groups (
Abstract The first catalytic asymmetric construction of the cyclic enaminone‐based 3‐substituted 3‐amino‐2‐oxindole scaffold with potential bioactivity has been developed via chiral phosphoric acid‐catalyzed enantioselective addition reactions enaminones to isatin‐derived imines, which afforded a series 3‐amino‐2‐oxindoles in high yields and excellent enantioselectivities (up 99% yield, 97% ee ). investigation reaction mechanism suggested that it was facilitated by dual hydrogen‐bonding...
Abstract A new strategy for enantioselective synthesis of axially chiral naphthyl‐indoles has been established through catalytic asymmetric addition reactions racemic with bulky electrophiles. Under phosphoric acid catalysis, azodicarboxylates and o ‐hydroxybenzyl alcohols served as but reactive electrophiles that were attacked by C2‐unsubstituted naphthyl‐indoles, which underwent a dynamic kinetic resolution to afford two series in good yields (up 98 %) high enantioselectivities 98:2 er).
The first [4 + 2] cyclization of <italic>para</italic>-quinone methide derivatives with allenes has been established <italic>via</italic> phosphine catalysis, which afforded a series chroman in high yields (up to 97%) and excellent (<italic>E</italic>/<italic>Z</italic>)-selectivities (all >95 : 5 <italic>E</italic>/<italic>Z</italic>).
Given the rise of morbidity and mortality caused by Klebsiella pneumoniae (KP), increasing number strains resistant to antibiotics, emergence hypervirulent pneumonia, treatment KP infection becomes difficult; thus, novel drugs are necessary for treatment. Anthocyanins, or natural flavonoids, have an extensive effect against bacterial infection. However, few studies on anti-KP identified. Here, we evaluated therapeutic purple sweet potato anthocyanins (PSPAs) KP, containing 98.7% delphinidin...
The prevalence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (hv-CRKP) is a serious public threat globally. Here, we performed clinical, molecular, and phenotypic monitoring hv-CRKP strains isolated from the intensive care unit (ICU) to offer evidence for prevention control in hospitals.Data analysis ICU patients suffering ventilator-associated pneumonia (VAP) because infection, admitted at Chinese Teaching Hospital between March 2019 September 2021 was performed. Patients'...
The first organocatalytic oxyarylation of styrenes has been established through a cascade vinylogous Michael addition/alkoxyl transfer reactions o- or p-hydroxylstyrenes with quinone imine ketals. process leads to highly chemo- and regioselective provides access m-alkylated anilines in generally high yields excellent diastereoselectivity (up 99% yield, >95:5 dr). An investigation the reaction pathway revealed that existence position hydroxyl group styrene played crucial roles reaction,...
The title reaction has been established to construct indole-fused five-membered rings in good yields (up 86%).
Streptococcus suis is a zoonotic pathogen that causes serious systemic infections in pigs and occupation-related humans who contact with or pork products. In China, it has caused two outbreaks of human infection surveillance for S.suis been ongoing since last time.Two cases meningitis sepsis by S. were reported this study. Both patients work relation to the trade, risk factor infection. The outcome was favorable after prolonged ceftriaxone therapy but one patient left mild hearing loss. Two...
A catalytic asymmetric substitution of 3-substituted 2-indolylmethanols with 2-naphthols has been established under the catalysis chiral phosphoric acid. By this approach, a series structurally diversified triarylmethane derivatives were obtained in moderate to high yields good enantioselectivities (up 97% yield, 95:5 er). This approach not only enriches chemistry 2-indolylmethanol-inolved substitutions, but also provides useful method for enantioselective synthesis derivatives.