A5101489904- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Insect Resistance and Genetics
- Catalytic Alkyne Reactions
- Protein Structure and Dynamics
- Cyclopropane Reaction Mechanisms
- Renal cell carcinoma treatment
- Axial and Atropisomeric Chirality Synthesis
- Synthesis and Catalytic Reactions
- Asymmetric Synthesis and Catalysis
- Insect-Plant Interactions and Control
- Synthesis of Indole Derivatives
- Oxidative Organic Chemistry Reactions
- Autophagy in Disease and Therapy
- Cancer Research and Treatments
- Renal and related cancers
- Biofuel production and bioconversion
- Cannabis and Cannabinoid Research
- Enzyme Structure and Function
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- Bioactive Compounds and Antitumor Agents
- Protease and Inhibitor Mechanisms
- Organ Donation and Transplantation
Wuhan University
2017-2025
Peking University
2022-2025
Peking University Third Hospital
2024-2025
Zhejiang Sci-Tech University
2025
Sun Yat-sen University
2022-2024
Jiangsu Normal University
2019-2021
South China Agricultural University
2019
Wenzhou Medical University
2018
This review summarizes advances in vinylindole-based organocatalytic asymmetric reactions since 2008 and includes the applications of some methodologies total synthesis natural products, points out remaining challenges this research area.
Enantioselective construction of all-carbon quaternary stereocenters has attracted much attention over the past few decades. A variety catalytic asymmetric methods have been disclosed based on use presynthesized complex reagents that impart congested steric hindrance to reaction center, which generally produce chiral molecules through forming one C-C bond. The readily available could build two bonds same carbonic center with concomitant assembly remains challenging. Herein, we disclose a...
The fall armyworm, Spodoptera frugiperda , is a lepidopteran pest that feeds on many economically important cereal crops such as corn, rice, sorghum, and sugarcane. Native to the Americas, it has become serious invasive in Africa Asia. Recently, this was found China spread quickly across country. As S. will most likely major China, Integrated Pest Management strategies, including biological control methods, should be developed manage its populations. Here, we report detection of Telenomus...
Abstract Enzymes largely exist in various oligomeric states, but monomeric enzymes are more conducive to industrial applications. Converting an enzyme into active monomer is a significant challenge. In this study, we present de novo design strategy convert fluoroacetate dehalogenase (FAcD) from its native dimeric form monomer. Using the AI-based method ProteinMPNN, identified critical protein-protein interaction (PPI) sites at dimer interface. ArDCA, another AI tool, was employed pinpoint...
Hypoxia-related adenosine (Ado) exerts an immunosuppressive effect in tumors by binding to the metabolic checkpoint Ado A2A receptors (A2AR), thereby hindering activation of antitumor immunity induced immunogenic cell death (ICD). In this study, a MnO2-assisted photosynthetic bacteria (PSB) biohybrid (MnO2@PSB) is developed enhance tumor photothermal immunotherapy interfering with Ado-A2AR pathway. Specifically, manganese dioxide (MnO2) nanoflowers are conjugated onto PSB carbodiimide...
The asymmetric electrophilic amination using azodicarboxylates as the N-source for construction of C–N bond has attracted much attention over past decades. However, use in situ formed nucleophilic intermediates, rather than bench-stable reagents, remains elusive and challenging. Herein, we disclose an enantioselective reaction generated alkylgold species with under a gold complex chiral quinine-derived squaramide (QN-SQA) synergetic catalysis, leading to alkylideneoxazolines...
A catalytic asymmetric synthesis of 3,3′-bisindoles bearing single axial chirality has been established via chiral phosphoric acid (CPA)-catalyzed enantioselective addition reaction with ninhydrin-derived 3-indolylmethanols. The selection 3-indolylmethanols as suitable electrophiles is based on the consideration that symmetric and bulky moiety ninhydrin would increase steric congestion around axis to generate stable avoid generation central chirality. By this approach, a series were...
A novel single-molecular fluorescent probe was developed for spatiotemporal matrix metalloproteinase-2 (MMP-2) and caspase-3 imaging with distinct fluorescence signals. Due to the multi-Förster resonance energy transfer (FRET) processes, could respond MMP-2 independently high signal-to-noise ratio. Moreover, overexpression of in cancer cell lines cisplatin induced apoptosis were imaged emissions. Because independent process imaging, meet demands precise disease diagnosis theranostic...
The first [4 + 2] cyclization of <italic>para</italic>-quinone methide derivatives with allenes has been established <italic>via</italic> phosphine catalysis, which afforded a series chroman in high yields (up to 97%) and excellent (<italic>E</italic>/<italic>Z</italic>)-selectivities (all >95 : 5 <italic>E</italic>/<italic>Z</italic>).
The title reaction has been established to construct indole-fused five-membered rings in good yields (up 86%).
A catalytic asymmetric substitution of 3-substituted 2-indolylmethanols with 2-naphthols has been established under the catalysis chiral phosphoric acid. By this approach, a series structurally diversified triarylmethane derivatives were obtained in moderate to high yields good enantioselectivities (up 97% yield, 95:5 er). This approach not only enriches chemistry 2-indolylmethanol-inolved substitutions, but also provides useful method for enantioselective synthesis derivatives.
The first application of 3-alkyl-2-vinylindoles in catalytic asymmetric dearomative cycloadditions was established by chiral phosphoric acid (CPA)-catalyzed (2+3) cycloaddition with azoalkenes, leading to the generation pyrroloindolines bearing two tetrasubstituted stereogenic centers good yields (61–96%) and excellent stereoselectivities (all >95:5 dr, 86–99% ee). This reaction has realized enantioselective 3-alkyl-2-vinylindoles, which brings a new reactivity this class vinylindoles will...
The drive to enhance enzyme performance in industrial applications frequently clashes with the practical limitations of exhaustive experimental screening, underscoring urgency for more refined and strategic methodologies engineering. In this study, xylanase Xyl-1 was used as model, coupling evolutionary insights energy functions obtain theoretical potential mutants, which were subsequently validated experimentally. We observed that mutations nonloop region primarily aimed at enhancing...
Abstract Chiral fully‐substituted allenes are synthetically significant and pivotal building blocks that can engage in diverse transformations toward a variety of bioactive molecules. The enantioselective assembly these skeletons using readily available reactants offers advantages but remains challenging. Herein, an asymmetric formal Michael‐type addition alkynyl imines with the key alkylgold intermediates derived situ from N ‐propargylamides is accomplished under gold‐complex chiral...
Most GH11 family endo-β-1,4-xylanases contain a propeptide region linked to the N-terminal region. The mechanistic basis of this harboring key regulation information for enzyme function, however, remains poorly understood. We reported an investigation on allosteric mechanism based biochemical characterization, molecular dynamics simulations, and evolutionary analysis. discovered that mutant truncated shows remarkably increased thermal stability (melting temperature by 11.5 °C) catalytic...
Abstract Accumulating evidence suggests that autophagy plays a protective role in chondrocytes and prevents cartilage degeneration osteoarthritis (OA). The objective of this study was to investigate the effect diazoxide on chondrocyte death determine whether these effects are correlated experimental OA. In study, cellular OA model established by stimulating SW1353 cells with interleukin 1β. A rat generated transecting anterior cruciate ligament combined resection medial menisci, followed...
An asymmetric three-component reaction via Mannich-type interception of an oxonium ylide with a 7-membered imine has been disclosed, providing chiral dibenzoazepine analogues excellent stereoselectivity and structural diversity.