A5100439711- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Cancer, Stress, Anesthesia, and Immune Response
- Extracellular vesicles in disease
- Transgenic Plants and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- X-ray Diffraction in Crystallography
- Microbial Metabolism and Applications
- Virus-based gene therapy research
- Adenosine and Purinergic Signaling
- 3D Printing in Biomedical Research
- Click Chemistry and Applications
- Animal Genetics and Reproduction
- Cardiovascular Health and Risk Factors
- Cardiac Valve Diseases and Treatments
- Protein Tyrosine Phosphatases
- Supramolecular Self-Assembly in Materials
Wuhan University
2007-2025
Hubei University
2020-2025
Southwest Hospital
2024
Army Medical University
2024
KTH Royal Institute of Technology
2024
Dalian University
2022
Dalian University of Technology
2022
Northeast Agricultural University
2015
Iowa State University
2007-2009
Peking University
2009
Abstract A photothermal bacterium (PTB) is reported for tumor‐targeted therapy (PTT) by using facultative anaerobic Shewanella oneidensis MR‐1 ( S. MR‐1) to biomineralize palladium nanoparticles (Pd NPs) on its surface without affecting bacterial activity. It found that PTB possesses superior property in near infrared (NIR) regions, as well preferential tumor‐targeting capacity. Zeolitic imidazole frameworks‐90 (ZIF‐90) encapsulating photosensitizer methylene blue (MB) are hybridized the of...
Abstract Cancer has been the most deadly disease, and 13 million cancer casualties are estimated to occur each year by 2030. Gold nanoparticles (AuNPs)‐based photothermal therapy (PTT) attracted great interest due its high spatiotemporal controllability noninvasiveness. Due trade‐off between particle size efficiency of AuNPs, rational design is needed realize aggregation AuNPs into larger particles with desirable NIR adsorption in tumor site. Exploiting bioorthogonal “Click Release” (BCR)...
Carbon monoxide (CO) is regarded as a potential therapeutic agent with multiple beneficial functions for biomedical applications. In this study, versatile CO nanogenerator (designated PPOSD) was fabricated and developed tumor therapy anti-inflammation. Partially oxidized tin disulfide (SnS2) nanosheets (POS NSs) were decorated tumor-targeting polymer (polyethylene glycol-cyclo(Asp-d-Phe-Lys-Arg-Gly), PEG-cRGD), followed by the loading of chemotherapeutic drug doxorubicin (DOX) to prepare...
Although vascular disrupting agents (VDAs) have been extensively implemented in current clinical tumor therapy, the notable adverse events caused by long-term dosing severely limit therapeutic efficacy. To improve this we report a strategy for VDA-induced aggregation of gold nanoparticles to further destroy photothermal effect. This could effectively disrupt and cut off nutrition supply after just one treatment. In murine model, results growth inhibition gives rise 92.7% suppression growth....
Photothermal therapy (PTT) is an effective treatment modality with high selectivity for tumor suppression. However, the inflammatory responses caused by PTT may lead to adverse reactions including recurrence and therapeutic resistance, which are regarded as major problems PTT. Here, a near-infrared (NIR) light-responsive nanoreactor (P@DW/BC) fabricated simultaneously realize carbon monoxide (CO)-mediated anti-inflammatory therapy. Defective tungsten oxide (WO3) nanosheets (DW NSs) decorated...
Abstract Immunogenic cell death (ICD) induced by specific chemotherapeutic agents is often hampered the immunosuppressive tumor microenvironment (TME). Here, a bacterial bioreactor E@Fe‐DOX, developed, to enhance ICD‐mediated antitumor immunity in situ manipulation of metabolism‐immune interactions. The E@Fe‐DOX constructed depositing doxorubicin‐loaded iron‐polyphenol nanoparticles on Eubacterium hallii , which can specifically target hypoxic regions and release doxorubicin Fe 3+ induce...
The effectiveness of various cancer therapies for solid tumors is substantially limited by the highly hypoxic tumor microenvironment (TME). Here, a microalgae-integrated living hydrogel (ACG gel) developed to concurrently enhance hypoxia-constrained starvation therapy and immunotherapy. ACG gel formed in situ following intratumoral injection biohybrid fluid composed alginate, Chlorella sorokiniana, glucose oxidase, facilitated crossing-linking between divalent ions within alginate....
Abstract By leveraging the ability of bacteria to express therapeutic protein cytolysin A (ClyA) through plasmid transformation, a thermally‐activated biohybrid (TAB@Au) is constructed by biomineralizing gold nanoparticles (AuNPs) on E. coli surface. Due feature anaerobic homing tumor microenvironments, bacteria‐based antitumor vehicles can be efficaciously accumulated at sites. Under NIR laser irradiation, biomineralized AuNPs harvest transdermal photons and convert them into local heat for...
Abstract Given the special microenvironment of solid tumors, live microorganisms have emerged as drug delivery vehicles and therapeutic agents. Here, an acid‐induced platform is constructed using attenuated Escherichia coli to express cytolysin A protein. The bacteria can target colonize tumor tissues without causing notable host toxicity. Bacterial infection disrupt blood vessels trigger thrombosis in tissues, resulting cut‐off nutrient supply cells arrest growth. expression induced by...
The interaction between platelets and circulating tumor cells (CTCs) contributes to distal metastasis by protecting CTCs from immunological assault shear stress, which can be disrupted nitric oxide (NO) through inhibiting platelet-mediated adhesion. To eradicate primitive tumors inhibit CTC-based pulmonary metastasis, a novel biomimetic nanomedicine (mCuMNO) is designed encapsulating Cu+ -responsive S-nitrosoglutathione as NO donor into copper-based metal-organic framework (CuM). This work...
Hypoxia-related adenosine (Ado) exerts an immunosuppressive effect in tumors by binding to the metabolic checkpoint Ado A2A receptors (A2AR), thereby hindering activation of antitumor immunity induced immunogenic cell death (ICD). In this study, a MnO2-assisted photosynthetic bacteria (PSB) biohybrid (MnO2@PSB) is developed enhance tumor photothermal immunotherapy interfering with Ado-A2AR pathway. Specifically, manganese dioxide (MnO2) nanoflowers are conjugated onto PSB carbodiimide...