A5008647675- Glycosylation and Glycoproteins Research
- Nanoplatforms for cancer theranostics
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Congenital Heart Disease Studies
- Remote Sensing and Land Use
- Nanoparticle-Based Drug Delivery
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Genomics and Phylogenetic Studies
- Soft tissue tumor case studies
- Electrocatalysts for Energy Conversion
- Digital Imaging for Blood Diseases
- IgG4-Related and Inflammatory Diseases
- T-cell and B-cell Immunology
- Pharmacology and Obesity Treatment
- Environmental Quality and Pollution
- Drug-Induced Ocular Toxicity
- Colorectal Cancer Screening and Detection
- Cancer, Lipids, and Metabolism
- Remote-Sensing Image Classification
China University of Geosciences
2021-2024
Hubei University
2020-2024
Shanghai Children's Hospital
2020-2024
Shanghai Jiao Tong University
2004-2024
Shanghai International Studies University
2022
Dalian University
2022
Dalian University of Technology
2022
Ningxia Medical University
2018-2022
Fudan University
2016-2021
Zhongnan Hospital of Wuhan University
2020
Abstract By leveraging the ability of bacteria to express therapeutic protein cytolysin A (ClyA) through plasmid transformation, a thermally‐activated biohybrid (TAB@Au) is constructed by biomineralizing gold nanoparticles (AuNPs) on E. coli surface. Due feature anaerobic homing tumor microenvironments, bacteria‐based antitumor vehicles can be efficaciously accumulated at sites. Under NIR laser irradiation, biomineralized AuNPs harvest transdermal photons and convert them into local heat for...
Abstract Given the special microenvironment of solid tumors, live microorganisms have emerged as drug delivery vehicles and therapeutic agents. Here, an acid‐induced platform is constructed using attenuated Escherichia coli to express cytolysin A protein. The bacteria can target colonize tumor tissues without causing notable host toxicity. Bacterial infection disrupt blood vessels trigger thrombosis in tissues, resulting cut‐off nutrient supply cells arrest growth. expression induced by...
When it comes to the application of photon data gathered by Ice, Cloud, and Land Elevation Satellite-2 (ICESat-2), accurately removing noise is crucial. In particular, conventional denoising algorithms based on local density are susceptible missing some signal photons when there uneven distribution, as well being misclassifying near photons; deep learning remains untapped in this domain well. To solve these problems, a method for extracting GoogLeNet model fused with Convolutional Block...
Purpose: Gastric cancer (GC), one of the world's top five most common cancers, is third leading cause related death. It urgent to identify non-invasive biomarkers for GC. The objective our study was find out early detection and surveillance GC based on glycomic analysis. Method: Ethyl esterification derivatization combined with MALDI-TOF MS analysis employed comprehensive serum in order investigate glycan markers that would indicate onset progression gastric cancer. Upon discovery candidate...
The interaction between platelets and circulating tumor cells (CTCs) contributes to distal metastasis by protecting CTCs from immunological assault shear stress, which can be disrupted nitric oxide (NO) through inhibiting platelet-mediated adhesion. To eradicate primitive tumors inhibit CTC-based pulmonary metastasis, a novel biomimetic nanomedicine (mCuMNO) is designed encapsulating Cu+ -responsive S-nitrosoglutathione as NO donor into copper-based metal-organic framework (CuM). This work...
Ovarian cancer is one of the most lethal gynecological malignancies, in which platinum resistance a common cause its relapse and death. Glycosylation has been reported to be involved drug resistance, glycomic analyses ovarian may improve our understanding mechanisms underlying cell provide potential biomarkers therapeutic targets. The serous line A2780 platinum-resistant counterpart A2780-cp were used this study. We performed lectin array analysis compare glycosylation patterns two lines,...
Uraemic pruritus (UP) is one of the most common problems in patients with chronic renal failure. Owing to complexity UP, no specific treatment currently available. Recently, accumulated toxins mid and macro molecules advanced failure have been proposed play an important role mediation pruritus.To evaluate effect high permeability haemodialysis (HPHD) against conventional (CHD) on UP.A randomized, prospective, double-blind study was performed compare efficacy HPHD CHD UP. In total, 116 UP...
Background: Peritoneal metastasis, associated with poor prognosis in gastric cancer, is difficult to discriminate from advanced cancer preoperatively.However, operative diagnosis could bring both mental and physical trauma economic burden for patients.Consequently, a non-invasive biomarker necessary reduce the of improve survival quality patients.This study aims elucidate correlation between Immunoglobulin G (IgG) N-glycome peritoneal metastasis find potential biomarkers preoperative...
Neoadjuvant chemotherapy (NACT) could improve prognosis and survival quality of patients with local advanced gastric cancer (LAGC) by providing an opportunity radical operation for them. However, no effective method predict the efficacy NACT before surgery to avoid potential toxicity, time-consuming economic burden ineffective chemotherapy. Some research has been investigated about correlation between serum IgG glycosylation cancer, but question whether glycome can reflect tumor response is...
The rapid development of fintech has significantly impacted the traditional financial market and brought technological opportunities for commercial banks. In this context, based on a sample 36 Chinese banks from 2003-2019, paper empirically investigates impact performance through textual analysis. results show that effects banks' are mixed, where technology basis significant negative performance, electronic payment can enhance earnings. addition, both effect positive bank more substantial...
Although nerve damage/toxicity has been shown to be one of the side effects in patients given prolonged antibiotic treatment, mechanisms action antibiotics on neuron cells are not clear. In this work, we investigated toxicity piperacillin (an that can penetrate blood-brain barrier) and its underlying mechanisms. We show clinically relevant doses induce apoptosis SH-SY5Y human primary through activating caspase-3 activity decreasing Mcl-1 Bcl-2 levels. addition, causes mitochondrial...
Peritoneal metastasis (PM) in gastric cancer (GC) remains an untreatable disease, and is difficult to diagnose preoperatively. Here, we aim establish a novel prediction model.The clinicopathologic characteristics of cohort that included 86 non-metastatic GC patients 43 PMGC from Zhongshan Hospital were retrospectively analysed identify PM associated variables. Additionally, mass spectrometry glycomic analysis applied the same find biomarkers serum for diagnosis PM. A nomogram was established...
Background: Neuroblastoma (NB) is the most frequent pediatric malignant neoplasm that originates from embryonic neural crest cells. Urinary catecholamines in 24-h urine are commonly analyzed for diagnosis of neuroblastoma at good sensitivity; however, it challenging to collect samples a population. Therefore, development more rapid, non-invasive and cost-effective tools NB remains needed. Serum immunoglobulin G (IgG) galactosylation have been found highly associated with adult cancers our...
Ovarian cancer is the most lethal gynecological malignancy due to its frequent recurrence and drug resistance even after successful initial treatment. Accumulating scientific evidence indicates that subpopulations of cells with stem cell-like properties, such as so-called side population (SP) cells, are primarily responsible for these recurrences. A better understanding SP may provide new clues detecting targeting cancer-initiating ultimately help eradicate cancer. Changes in glycosylation...
Urban change detection (CD) using remote sensing images is of great significance for monitoring and analyzing the spatial temporal distribution changes within cities, which can be used to guide urban management. In order reduce false detections improve CD automation, a novel framework high resolution proposed in this article. First, multilevel matching feature presented, combining structural invariant features with multiscale dense comprehensively describe properties ground objects at...
Background: Although Carbohydrate antigen 19-9 (CA19-9) is considered clinically useful and informative for pancreatic carcinoma (PC), false positive results, negative results have restricted its clinical use. Especially missed or delayed diagnosis of PC patients with CA19-9 value limited the utility. To improve prognosis patients, discovery reliable biomarkers to assist desired. Serum IgG galactosylation based on our previous report was altered in comparing healthy controls. The objective...
A targeted drug delivery system with lessened side effects and real-time monitoring of tumor cell apoptosis is highly desirable for precision therapy. Herein, we developed a traceable self-assembled micelle (TPR@DOX) by grafting Arg-Gly-Asp (RGD) peptide tetraphenylethene (TPE) fluorophore on both axial positions amphiphilic polymers. The aggregation-induced emission (AIE) characteristics TPE makes the visible high-quality imaging, indicating loading release doxorubicin (DOX) during process....
This study investigated the effects of alprostadil combined with calcium dobesilate on treatment diabetic nephropathy. We recruited 80 patients nephropathy, who were randomly divided into experimental (n=40) and control groups. Patients received high-quality low-protein diet intervention subcutaneous injection insulin to adjust blood glucose, antihypertensive, antiplatelet drugs, other comprehensive treatments. The group dobesilate. Both groups treated for 12 weeks as one cycle. time...