A5072119475- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- RNA Research and Splicing
- Biomedical Research and Pathophysiology
- Cancer-related gene regulation
- Pharmacological Effects and Toxicity Studies
- RNA modifications and cancer
- Neurological Complications and Syndromes
- Cellular transport and secretion
- Receptor Mechanisms and Signaling
- Autoimmune Neurological Disorders and Treatments
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Trace Elements in Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Hereditary Neurological Disorders
- Gut microbiota and health
- Inflammasome and immune disorders
- Cannabis and Cannabinoid Research
Chongqing Medical University
2018-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2018-2024
Abstract It is long been suggested that one‐carbon metabolism (OCM) associated with Alzheimer's disease (AD), whereas the potential mechanisms remain poorly understood. Taking advantage of chemical biology, mitochondrial serine hydroxymethyltransferase (SHMT2) directly regulated translation ADAM metallopeptidase domain 10 (ADAM10), a therapeutic target for AD reported. That small‐molecule kenpaullone (KEN) promoted ADAM10 via 5′ untranslated region (5′UTR) and improved cognitive functions in...
Epilepsy is a common disease of the nervous system. Autophagy degradation process involved in epilepsy, and turn, seizures can activate autophagy. Beclin1 plays critical role autophagy participates numerous physiological pathological processes. However, mechanism underlying effect on epilepsy remains unclear. In this study, we detected increased expression brain tissues from patients with temporal lobe (TLE). Heterozygous disruption beclin1 decreased susceptibility to suppressed seizure...
Abstract Epilepsy is a common nervous system disease, and the existing theory does not fully clarify its pathogenesis. Recent research suggests that intestinal microbes may be involved in development of epilepsy, but which microbe remains unclear. We used 16s rRNA sequencing to identify most relevant gut microbe. To determine relationship between this we an animal model. In addition, western blotting immunofluorescence, as well inhibitor studies, were evaluate confirm role microglia process....
The imbalance between excitation and inhibition is a defining feature of epilepsy. GluA1 an AMPA receptor subunit that can strengthen excitatory synaptic transmission when upregulated in the postsynaptic membrane, which has been implicated pathogenesis cGKII, cGMP-dependent protein kinase, regulates levels at plasma membrane.To explore role cGKII epilepsy, we investigated expression patients with temporal lobe epilepsy (TLE) pilocarpine-induced rat model then performed behavioral,...