A5103197486- Cardiac Imaging and Diagnostics
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Coronary Interventions and Diagnostics
- Psoriasis: Treatment and Pathogenesis
- Adipokines, Inflammation, and Metabolic Diseases
- Extracellular vesicles in disease
- Cancer Treatment and Pharmacology
- Atherosclerosis and Cardiovascular Diseases
- Advanced X-ray and CT Imaging
- Lipid metabolism and disorders
- Sphingolipid Metabolism and Signaling
- Calcium signaling and nucleotide metabolism
- Cytokine Signaling Pathways and Interactions
- Kruppel-like factors research
- Acute Myocardial Infarction Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Takotsubo Cardiomyopathy and Associated Phenomena
- Antiplatelet Therapy and Cardiovascular Diseases
- Traditional Chinese Medicine Studies
- Metal-Catalyzed Oxygenation Mechanisms
- IL-33, ST2, and ILC Pathways
- Cardiac tumors and thrombi
- Cardiac Fibrosis and Remodeling
- Circular RNAs in diseases
Huazhong University of Science and Technology
2021-2024
Shenzhen University
2024
Union Hospital
2021-2024
ShenZhen People’s Hospital
2019-2021
Neurology, Inc
2021
Military Hospital
2021
Shenzhen University Health Science Center
2021
Guangdong Medical College
2010-2019
Anshan Hospital
2016-2019
Shenzhen Sixth People's Hospital
2013
Intravenous recombinant tissue plasminogen activator (r-tPA) and urokinase (UK) are both recommended for the treatment of acute ischaemic stroke (AIS) in China, but with few comparative outcome data being available. We aimed to compare outcomes these two thrombolytic agents patients within 4.5 hours onset AIS routine clinical practice China.A pre-planned, prospective, nationwide, multicentre, real-world registry consecutive (age ≥18 years) who received r-tPA or UK symptom according local...
Myocardial ischemia triggers an inflammatory reaction and oxidative stress that increases apoptosis of myocardiocytes. It has been evidenced tanshinone‑IIA (Tan‑IIA) protects against heart failure post‑myocardial infarction via inhibition the apoptotic pathway. The purpose present study was to investigate therapeutic effect Tan‑IIA in a rat model myocardial ischemia, explore possible mechanism established by left anterior descending coronary artery rats received treatment with either (10...
Acute myocardial infarction (AMI) is a fatal cardiovascular disease with high mortality rate. The discovery of effective biomarkers crucial for the diagnosis and treatment AMI. In present study, miRNA sequencing reverse transcription-quantitative polymerase chain reaction techniques revealed that expression exosome derived miR-152-5p was significantly downregulated in patients AMI compared healthy controls. A series functional validation experiments were then performed using H9c2...
Abstract Background Early detection of patients concomitant with left main and/or three‐vessel disease (LM/3VD) and high SYNTAX score (SS) is crucial for determining the most effective revascularization options regarding use antiplatelet medications prognosis risk stratification. However, there a lack study predictors LM/3VD SS in non‐ST‐segment elevation myocardial infarction (NSTEMI). We aimed to identify potential factors that could predict (SS > 22) NSTEMI. Methods This dual‐center...
// Tengyu Yang 1, * , Fang 2, Yawen Chen 1 Jing Ma Zhaowen Xiao Songfeng Zou Na Zheng Dewen Yan 4 Songyan Liao Shaoyuan 3 Hongchen Chekmen Yu 2 Jie Liu Ming Dong Division of Pathophysiology, Medical College, Shenzhen University, Shenzhen, Guangdong, China cardiology, Department Medicine and Therapeutics, Prince Wales Hospital, Li Ka Shing Institute Health Sciences, Vascular Medicine, The Chinese University Hong Kong, Cardiology Division, Nanshan Hostipal, Endocrinology, First Affiliated...
Recently, the evidence showed that interleukin-37 (IL-37) was expressed in foam-like cells of atherosclerotic coronary and carotid artery plaques IL-37-transgenic mice, suggesting is involved atherosclerosis-related diseases. The purpose this study to determine change IL-37 plaque, effect atorvastatin on association between Smad3 disease. Rabbits were subjected atherosclerosis by immunologic injury composite with balloon (BI). Some rabbits received treatment from 6 weeks 12 weeks. Serum...
Abstract Background Ischemia with non-obstructive coronary artery disease is a prevalent form of ischemic heart disease. The majority ischemia cases are attributed to underlying factors such as microvascular dysfunction (CMD) and/or spasm. can present various clinical manifestations. Recurrent syncope an atypical complaint in patients Case presentation This case report describes the 58-year-old Chinese male patient who experienced repeated episodes syncope. was found be caused by concomitant...
Objective: Dendritic cells (DCs) activation is important in atherosclerosis and coronary heart disease, but the mechanisms regulating of dendritic remain largely unclear. The aim this study was to evaluate effect transcription factor Kruppel-like 2 (KLF2) proinflammatory DCs acute syndrome. Methods Results: In study, expression CD80 KLF2 detected normal health controls, patients with stable angina (SA), syndrome (ACS). Our found that compared control SA, reduced ACS. Moreover, surface...
The prevention and prognosis of the onset or recurrence acute myocardial infarction (AMI) is a difficult problem in contemporary research.In this study, peripheral blood samples were collected from seven patients with AMI nine healthy adults, exosome microRNAs (miRNAs) extracted. miRNA differential expression profiles serum exosomes obtained by using next-generation sequencing technology combined bioinformatics analysis. Reverse-transcriptase polymerase chain reaction (RT-PCR) was used to...
The purpose of this study was to investigate the role legumain in formation and stability atherosclerotic plaque, as well explore association between with Smad3 pathway a rat atherosclerosis model. Rat thoracic aorta established received treatment statin (n = 15 each) or controls 10). Serum level determined by enzyme-linked immunosorbent assay. Legumain aortic expression levels were assessed immunohistochemistry fluorescence microscopy. Protein mRNA analyzed using Western blot analysis...
1-Aryl-5-fluorouracil derivates are synthesized by the reaction of 5-fluorouracil with diaryliodonium salts.
Coronary artery spasm (CAS), one of the etiologies for myocardial infarction with non-obstructive coronary arteries (MINOCA), is an uncommon cause acute chest pain. Toripalimab, a recombinant monoclonal antibody targeting programmed death receptor 1 (PD-1), exhibits wide range anti-tumor activities, encompassing lung cancer and gastrointestinal tumors. Nevertheless, instances toripalimab-induced cardiotoxicity have been seldom reported. Herein, we present case 60-year-old male patient...
Objective To investigate the effect of interleukin-37(IL-37)/Smad3 on atherosclerosis by detecting expression IL-37 and Smad3 in atherosclerotic plaques. Methods Rabbit abdominal aorta models were established balloon injury. 20 male white rabbits randomly divided into control group (n=4, normal diet), experimental (n=8, high cholesterol drug diet add statin). Blood samples taken at beginning experiment, 6 weeks 12 later. At animals sacrificed obtained. Immunohistochemistry, Western...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”