Abstract Nanomaterials have been widely tested as new generation vaccine adjuvants, but few evoke efficient immunoreactions. Clay nanoparticles, for example, layered double hydroxide (LDH) and hectorite (HEC) shown their potent adjuvanticity in generating effective durable immune responses. However, the mechanism by which clay nanoadjuvants stimulate system is not well understood. Here, it demonstrated that LDH HEC–antigen complexes form loose agglomerates culture medium/serum. They also...

Triamcinolone acetonide (TA), a medium-potency synthetic glucocorticoid, is primarily employed to treat posterior ocular diseases using vitreous injection. This study aimed design novel nanoformulation drug delivery systems PLGA carriers overcome the barrier and facilitate effective into tissues after topical administration. The surface of nanodelivery system was made hydrophilic (2-HP-β-CD) through an emulsified solvent volatilization method, followed by characterization. mechanism cellular...

To review a rare case of lateral neck mass pathologically confirmed as an encapsulated papillary thyroid carcinoma in our center for complementing the lack management cases, and to explore differentiation primary ectopic metastatic disease context presence malignant tumors within situ gland. We searched studies on cancer compare analyze it with gland terms clinical features, imaging manifestations, pathological features at molecular level, treatment principles. Based available data, we...

Atypical meningioma (AM) has a high recurrence rate. This study explored the factors associated with and built predictive model for AM by combining radiomic clinical features. retrospective cohort enrolled 451 adult patients who underwent surgical treatment at three institutions between May 2012 April 2024. The in institution 1 were randomly assigned to training dataset (n = 246) or internal validation 164) ratio of 6:4, 2 3 composed external 41). pathological characteristics collected,...

Background Patients suffering from refractory obsessive-compulsive disorder (OCD) who have undergone deep brain stimulation (DBS) surgery require repeated in-person programming visits. These sessions could be labor-intensive and may not always feasible, particularly when hospital visits are restricted. Telemedicine is emerging as a potential supplementary tool for post-operative care. However, its reliability feasibility still further validation due to the unconventional methods of...

Myocardial ischemia triggers an inflammatory reaction and oxidative stress that increases apoptosis of myocardiocytes. It has been evidenced tanshinone‑IIA (Tan‑IIA) protects against heart failure post‑myocardial infarction via inhibition the apoptotic pathway. The purpose present study was to investigate therapeutic effect Tan‑IIA in a rat model myocardial ischemia, explore possible mechanism established by left anterior descending coronary artery rats received treatment with either (10...

The best surgical treatment of Chiari malformation patients with syringomyelia remains controversial, and whether cerebellar tonsillectomy should be performed has not been decided.To evaluate the efficacy posterior fossa decompression duraplasty (PFDD) Posterior resection tonsils (PFDRT) in type I (CM-I) explore relevant factors affecting prognosis.We retrospectively analyzed 182 adult CM-I who underwent PFDD or PFDRT over a 6-year period, their clinical manifestations, imaging features,...

Cerebral venous thrombosis (CVT), a rare type of cerebrovascular disease, can mimic brain tumor (CVT mimicking [CVTMBT]), due to its space-occupying imaging features. We aimed describe the clinicopathological features and identify thrombophilia-related gene expression changes in following CVT. conducted retrospective qualitative study CVT patients who were misdiagnosed with tumors before surgery at our hospital from 2016 2021. analyzed characteristics cases previously published cases. Five...

This study aimed to analyze the effect of preoperative fine needle aspiration cytology (FNAC) combined with BRAF

Background Remote programming (RP) is an emerging technology that enables the adjustment of implantable pulse generators (IPGs) via Internet for people with Parkinson's disease (PwPD) who have undergone deep brain stimulation (DBS). Previous studies not comprehensively explored effectiveness RP in managing motor symptoms, often omitting assessments such as rigidity and retropulsion tests during follow-up. This study evaluates comprehensive improvements performance potential cost benefits...

The purpose of this study was to investigate the role legumain in formation and stability atherosclerotic plaque, as well explore association between with Smad3 pathway a rat atherosclerosis model. Rat thoracic aorta established received treatment statin (n = 15 each) or controls 10). Serum level determined by enzyme-linked immunosorbent assay. Legumain aortic expression levels were assessed immunohistochemistry fluorescence microscopy. Protein mRNA analyzed using Western blot analysis...

Abstract Background Remote programming enables physicians to adjust implantable pulse generators over the internet for patients with Parkinson disease who have undergone deep brain stimulation (DBS) surgery. Despite these technological advances, demand and attitudes toward remote compared standard among are still not well understood. Objective This study aims investigate preferences perceptions associated 2 methods through a web-based survey. Methods A survey was administered 463 DBS The...

People with Parkinson's disease (PwPD) who undergo deep brain stimulation (DBS) surgery could benefit from remote programming (RP), which has proven to be both effective and economical. However, there is limited research on PwPD DBS implants have completed all sessions exclusively through means (full programming, FRP). This case report documents the experiences of five underwent FRP, four demonstrating improvements in motor symptoms, quality life, medication reduction. A total 22...

Background There is a considerable amount of controversy regarding the treatment and prognosis adult patients with Chiari malformation type I (CM-I) at home abroad; furthermore, no large-sample, long-term, follow-up studies have examined CM-I syringomyelia (SM) comparing posterior fossa decompression resection tonsils (PFDRT) vs. duraplasty (PFDD). Objective This study retrospectively analyzed factors affecting long-term adults combined SM. Methods We data from 158 SM who underwent PFDRT or...

Using unmanned aerial vehicles (UAVs) for bridge inspection is becoming increasingly popular due to its ability improve efficiency and ensure the safety of monitoring personnel. Compared traditional manual methods, UAV inspections are a safer more efficient alternative. This paper examines impact meteorological conditions on UAV-based during specific tasks, with aim enhancing UAV’s costly components. The wake vortex behind structure can vary over time airflow, which have direct flights. To...

To investigate the association of synaptobrevins/vesicle-associated membrane proteins 8 (VAMP8) gene rs1010 polymorphism with coronary heart disease (CHD) in Chinese Han population.The allele and genotype frequencies VAMP8 locus 185 CHD patients 149 controls were analyzed by using polymerase chain reaction-restriction fragment length (PCR-RFLP) DNA sequencing.There was studied population. The distribution genotypes Hardy-Weinberg equilibrium. frequency A group significantly higher than that...

Objective To investigate the correlation between heat-shock protein 70-2 (HSP70-2) gene+1267A/G polymorphism and coronary heart disease (CHD) in Han Chinese population. Methods Using method of polymerase chain reaction-restriction fragment length (PCR-RFLP) , genotype allele distribution HSP70-2 gene + 1267A/G 185 CHD patients 149 controls were analyzed. Results The was found this study population.The genotypes Hardy-Weinberg equilibrium. frequency G group significantly higher than that...

Abstract For Parkinson’s disease (PD) patients undergoing deep brain stimulation (DBS), remote programming (RP) was developed to eliminate the burden of repeat office visits for standard (SP) sessions maximize treatment effect. No studies comparing effects RP with SP directly were performed. Thirty-two propensity score matched retrospectively recruited and allocated or group according their methods, clinical outcomes compared at ~12-month follow-ups between two groups. differences found in...