A5102869705- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Fetal and Pediatric Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Cleft Lip and Palate Research
- Kruppel-like factors research
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Neurofibromatosis and Schwannoma Cases
- Adrenal and Paraganglionic Tumors
- Epilepsy research and treatment
- Spinal Dysraphism and Malformations
- Craniofacial Disorders and Treatments
- Neuroblastoma Research and Treatments
- Pharmacological Effects and Toxicity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive Health and Contraception
- Neurological Complications and Syndromes
- Biological Stains and Phytochemicals
- Head and Neck Surgical Oncology
- Neonatal and fetal brain pathology
- Vascular Malformations Diagnosis and Treatment
- Spinal Hematomas and Complications
Shenzhen Institutes of Advanced Technology
2024
Chinese Academy of Sciences
2024
First Affiliated Hospital of Zhengzhou University
2017-2024
Tongji University
2023
Third Affiliated Hospital of Zhengzhou University
2021-2022
Kaiser Permanente Baldwin Park Medical Center
2020
Peking Union Medical College Hospital
2016
Chinese Academy of Medical Sciences & Peking Union Medical College
2016
Craniopharyngiomas (CPs) are benign tumors arising from the sellar region. However, little is known about their clinical features and long-term recurrence due to low morbidity lack of large cohort studies. Thus, we aimed develop nomograms accurately predict extent resection tumor using parameters. A total 545 patients diagnosed with CP between 2009 2019 were examined: 381 in development 164 validation cohort. Least absolute shrinkage selection operator (LASSO) Cox regression analyses...
<title>Abstract</title> Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and limited therapeutic options. The blood-brain barrier (BBB) disruption post-ICH exacerbates secondary brain injury, highlighting the need for targeted therapies to preserve BBB integrity. This study aims investigate role of Sphk1/S1P pathway in breakdown following ICH evaluate potential Sphk1 inhibition mitigating this disruption. Using combination human patient samples, mouse models ICH,...
Abstract Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and limited therapeutic options. The blood-brain barrier (BBB) breakdown post-ICH exacerbates secondary brain injury, highlighting the need for targeted therapies to preserve BBB integrity. We aim investigate role of Sphk1/S1P pathway in following ICH evaluate potential Sphk1 inhibition mitigating this breakdown. Using combination human patient samples, mouse models ICH, vitro cellular assays, we assessed...
To investigate the clinicopathological features and related factors affecting microsurgical resection of lesions in cavernous sinus.Clinical data 66 patients undergoing microsurgery for located sinus from January 2011 to December 2017 were retrospectively reviewed.Histopathological examination revealed benign 60 (90.9%) patients, most common histopathological types meningiomas, schwannomas, hemangiomas. Only six (9.1%) had malignant lesions. The gross total rate was 33%, subtotal 21%,...
To compare the sensitivity and specificity between 24 hour urine free cortisol (24 h UFC) serum in dexamethasone suppression test (DST) diagnosis of Cushing syndrome (CS).Combined low dose DST (LDDST) high (HDDST) were carried out 67 cases CS with surgically confirmed recent 3 years(from January 2011 to November 2015). The UFC collected simultaneously for each subject compared.There disease (CD) group (n=53), ectopic adrenocorticotropic hormone (ACTH) (n=7) ACTH-independent according...
To compare and analyze the effects of cranial suture reconstruction frontal frame retraction for surgical treatment premature closure sagittal suture.Infants with were included in this study. All infants underwent preoperative skull model using imaging techniques 3D printing. The then allocated to either experiment group, where was used guide stenosis, or control traditional performed. interventions performed by same operator. two groups compared.Overall, 28 enrolled study, 15 experimental...
Background: Spinal cord glioblastoma multiforme (SCGBM) is an extremely rare malignant tumor. The study aims to present the clinical and imaging features of SCGBM. Methods: magnetic resonance (MRI) characteristics 12 pathologically proven SCBGM patients were retrospectively analyzed. Results: Three major MRI findings are as follows: (1) Mixed hypo-isointense signal on T1-weighted image (T1WI) hyper-isointense T2WI in all cases, (2) All except two demonstrated slight syringomyelia at upper or...
A solid hemangioblastoma (SH) is a benign and highly vascularized tumor. Microsurgical treatment of SH still challenging due to excessive intraoperative bleeding.Sixty-six consecutive patients with were retrospectively analyzed. The volume blood loss (IBL) the features detected by magnetic resonance imaging (MRI) evaluated neurosurgeon multiple neuroradiologists.Four striking MRI features-peritumoral edema, flow-void effect, large draining veins, visible feeding artery-were related IBL....
To predict the therapeutic effect of Cushing's disease after transsphenoidal surgery by using morning serum cortisol level.The clinical data 275 cases that had in Peking Union Medical College Hospital from 2010 to 2014 were analyzed retrospectively.Early level less than 140 nmol/L 3 days postoperation was usedto endocrinological remission. And long-term efficacy evaluated follow-up.Of patients, there 49 males and 226 females; average age 36.5 years old.Remission wasconfirmed 201 cases,...
Objectives: Total anomalous pulmonary venous connection (TAPVC) has no between the plexus and left atrial (PV-LA connection).In contrast, normal atrium a ridge embryologically caused by PV-LA junction.Thus, once is determined in fetal cardiac screening, TAPVC can be denied.We have developed novel autodetecting screening model using artificial intelligence (AI).In this study, we tested whether AI automatically detect PV-Laconnection.Methods: The ultrasound videos of 130 cases 6 were used.We...
Ultrasound examination is a vital tool for monitoring fetal development during pregnancy. However, the process of examining multiple images in specific planes diagnosis and measurement structures can be time-consuming error-prone doctors. In light this, our develop deep learning algorithm through effectively from unlabelled data to enable automatic plane detection improve speed accuracy diagnosis. The proposed approach was validated using maternal-fetal US set. self-supervised pre-trained by...
Abstract Objective Hydrocephalus following intraventricular hemorrhage is the most severe consequence of (IVH) in babies. However, it unclear what causes hydrocephalus. While case series describes hydrocephalus linked to bleeding, investigations have limitations. The authors set out examine morphological and demographic aspects a sizable cohort infants order address this. Methods clinical information 112 patients who were admitted Department Neurosurgery, third affiliated hospital Zhengzhou...
To compare, and to analyze the effects of fronto-orbital band anterior displacement in operation premature closure coronal suture infants.A total 31 infants with were randomly divided into two groups; experimental group (n=16) control (n=15). In group, skull model was reconstructed by an imaging examination three-dimensional (3D) printing technique before operation, anteriorly displaced during guide surgical treatment craniosynostosis. 3D not same operator. The groups compared.During...