A5015898666- Kidney Stones and Urolithiasis Treatments
- Bladder and Urothelial Cancer Treatments
- Pediatric Urology and Nephrology Studies
- Urinary and Genital Oncology Studies
- Parathyroid Disorders and Treatments
- Urological Disorders and Treatments
- Ureteral procedures and complications
- Tissue Engineering and Regenerative Medicine
- Renal and Vascular Pathologies
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Dialysis and Renal Disease Management
- Epigenetics and DNA Methylation
- Medical Imaging and Pathology Studies
- Cancer Research and Treatments
- Magnesium in Health and Disease
- Chronic Kidney Disease and Diabetes
- MRI in cancer diagnosis
- Drug-Induced Hepatotoxicity and Protection
- Therapeutic Uses of Natural Elements
- Memory and Neural Mechanisms
- Prostate Cancer Treatment and Research
- Trace Elements in Health
- Vitamin K Research Studies
- Bone and Dental Protein Studies
Tongji Hospital
2015-2024
Huazhong University of Science and Technology
2015-2024
GlaxoSmithKline (United Kingdom)
2001-2011
Royal Forest Department
2010
Unilever (United Kingdom)
2000-2001
National Institute for Communicable Disease Control and Prevention
1992
Berry extracts rich in anthocyanins have been linked to protective effects including the modulation of age-related neurological dysfunction and improvement resistance red blood cells against oxidative stress vitro . In this study bioavailability, metabolism elimination polyphenols from blackcurrant juice, anthocyanins, flavonols, hydroxycinnamates, were investigated. The four major native anthocyanidin glycosides delphinidin-3-glucoside, delphinidin-3-rutinoside, cyanidin-3-glucoside...
As one of the major risks for urolithiasis, hyperoxaluria can be caused by genetic defect or dietary intake. And high oxalate induced renal epithelial cells injury is related to oxidative stress and mitochondrial dysfunction. Here, we investigated whether MitoTEMPO, a mitochondria‐targeted antioxidant, could protect against mediated in NRK‐52E via inhibiting dysfunction modulating stress. MitoSOX Red was used determine ROS (mtROS) production. Mitochondrial membrane potential (Δ ψ m)...
Hyperoxaluria induces oxidative stress, and inflammation causes renal epithelial cell injury in nephrolithiasis, suggesting that reduced oxalate toxicity may be beneficial. This study aimed to investigate whether nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also called Nfe2l2) induced by dimethyl fumarate (DMF) could protect cells against oxalate-mediated both vivo vitro. Glyoxylic acid monohydrate was intraperitoneally injected into Sprague-Dawley rats with or without intragastric...
Calcium oxalate (CaOx) is the most common type of urinary stone. Increase ROS and NADPH oxidase gives rise to inflammation injury renal tubular cells, which promotes CaOx stone formation. Recent studies have revealed that renin‐angiotensin system might play a role in kidney crystallization production. Here, we investigated involvement Ang II/AT1R losartan NRK‐52E cells were incubated with crystals, glyoxylic acid‐induced hyperoxaluric rats treated losartan. Oxidative stress statuses...
Graphical Abstract
To investigate the associations of serum immunoglobulin (Ig) and complement levels with incident coronary heart disease (CHD), to explore potential mediating role C-reactive protein (CRP). We measured IgA, IgE, IgG, IgM, 3 (C3), 4 (C4), CRP in a nested case-control study within Dongfeng-Tongji cohort, consisting 1605 CHD cases age- sex-matched controls. quantified Ig using conditional logistic regression restricted cubic spline models. Mediation analysis was conducted these associations. The...
Aims: We aimed at exploring the role of nicotinamide adenine dinucleotide phosphate oxidase subunit 4 (Nox4) in regulation hypercalciuria-induced renal oxidative damage and crystal depositions. Results: High calcium activated Nox4 expression through protein kinase C (PKC). Downregulation attenuated osteoblast-associated expression, stress injury, deposition rat kidneys 1,25-dihydroxyvitamin D3 (VitD) urolithiasis model. Further, calcium-induced activation mitogen-activated (MAPK),...
It has been suggested that the memory enhancing effect of glucose follows an inverted U-shaped curve, with 25 g resulting in optimal facilitation healthy young adults. The aim this study was to further investigate dose dependency population across different domains and assess moderation by interindividual differences regulation weight. Following a double-blind, repeated measures design, 30 participants were administered drinks containing five doses (0 g, 15 50 60 g) tested range tasks....
Proteins are the most abundant component of kidney stone matrices and their presence may reflect process stone's formation. Many studies have explored proteomics urinary stones crystals. We sought to comprehensively identify proteins found in new, reliable biomolecules for use nephrolithiasis research.We conducted bioinformatics research November 2020 on used ClusterProfiler R package transform into corresponding genes Ensembl IDs. In each study we located where proteomic results intersected...
Accumulating evidence has suggested the impact of senescence on tumor progression, but no report yet described how shapes microenvironment clear cell renal carcinoma (ccRCC). The objective this study was to delineate features ccRCC and its role in shaping through a comprehensive analysis multiple datasets, including 2,072 samples. Unsupervised consensus clustering identified three subtypes, we found that senescence-activated subtype survived worst, even condition targeted therapy...
To clarify the outcome of flexible ureteroscopy (fURS) for management renal calculi without preoperative stenting.A total 171 patients who received 176 fURS procedures unilateral stones were reviewed. All divided into two groups depending on whether they ureteral stenting preoperatively. Baseline characteristics patients, stone burden, operation time, stone-free rates, and complications compared between both groups.Successful primary access to pelvis was achieved in 104 114 (91.2%) stenting,...
Background. MicroRNAs (miRNAs) influence a variety of biological functions by regulating gene expression post-transcriptionally. Aberrant miRNA has been associated with many human diseases. Urolithiasis is common disease, and idiopathic hypercalciuria (IH) an important risk factor for calcium urolithiasis. However, patterns their in urolithiasis remain unknown. Methods Results. A multi-step approach combining microarray mRNA profile bioinformatics analysis was adopted to analyze dysregulated...
Idiopathic hypercalciuria is an important risk factor for the formation of calcium-containing kidney stones. Matrix metalloproteinase-9 (MMP-9) closely related to cell and tissue remodeling involved in ectopic calcification. However, little known about its role stone formation. In this study, we found that expression MMP-9 osteoblastic-related proteins was increased normal rat epithelial-like (NRK-52E) cells following treatment with a high concentration calcium, while knockout or...
The objective of this research was to measure the effects energising drinks containing caffeine and glucose, upon mental activity during sustained selective attention. Non-invasive electrophysiological brain recordings were made a behavioural study attention in which participants received either or placebo drinks. We tested specifically whether have significant measures performance task requiring visual attention, as well on accompanying components event-related potential (ERPs) related...