A5100320867- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Pregnancy and Medication Impact
- Nanoparticle-Based Drug Delivery
- Systemic Lupus Erythematosus Research
- MicroRNA in disease regulation
- Gynecological conditions and treatments
- Rheumatoid Arthritis Research and Therapies
- Birth, Development, and Health
- Spondyloarthritis Studies and Treatments
- Nanoplatforms for cancer theranostics
- Neonatal Respiratory Health Research
- Signaling Pathways in Disease
- Endometriosis Research and Treatment
- RNA Interference and Gene Delivery
- Ovarian cancer diagnosis and treatment
- Dendrimers and Hyperbranched Polymers
- RNA modifications and cancer
- RNA Research and Splicing
Women's Hospital, School of Medicine, Zhejiang University
2019-2024
Zhejiang University
2023
Ovarian cancer is a common malignancy in the female reproductive system with high mortality rate. The most important reason multidrug resistance (MDR) of chemotherapy. To reduce side effects, reverse and improve efficacy for treatment ovarian cancer, "core-shell" polymeric nanoparticle-mediated curcumin paclitaxel co-delivery platform was designed.Nuclear magnetic resonance confirmed successful grafting polyethylenimine (PEI) stearic acid (SA) (PEI-SA), which designed as mother core...
Abstract Background The cytoskeletal protein, PSTPIP2, is associated with inflammation and predominantly expressed in macrophages. Previous data have shown that PSTPIP2 inhibits articular bone damage arthritic rats. aim of this study to explore the molecular mechanism PSTPIP2’s resistance erosion. Methods In current study, peripheral blood surgically excised synovial tissue from RA patients, DBA/1 mice, Pstpip2 Cre R26- ZsGreen reporter Esr2 fl/fl / Adgre -Cre tool mice were used for vivo...
Mutations or dysregulated expression of NF-kappaB-activating protein (NKAP) family genes have been found in human cancers. How NKAP gene mutations promote tumor initiation and progression remains to be determined. Here, we characterized dNKAP, the Drosophila homolog NKAP, showed that impaired dNKAP function causes genome instability tumorigenic growth a epithelial model. dNKAP-knockdown wing imaginal discs exhibit characteristics, including tissue overgrowth, cell-invasive behavior, abnormal...