A5008583357- Gut microbiota and health
- Circular RNAs in diseases
- Bone Metabolism and Diseases
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Pregnancy and Medication Impact
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Pregnancy and preeclampsia studies
- Bone health and treatments
- Bone health and osteoporosis research
- Wnt/β-catenin signaling in development and cancer
- Neurological Disease Mechanisms and Treatments
- Ginseng Biological Effects and Applications
- RNA Research and Splicing
- Antibiotics Pharmacokinetics and Efficacy
- Gestational Trophoblastic Disease Studies
- Advanced Nanomaterials in Catalysis
- Hippo pathway signaling and YAP/TAZ
- Nanoparticle-Based Drug Delivery
- Liver physiology and pathology
- Extracellular vesicles in disease
Women's Hospital, School of Medicine, Zhejiang University
2019-2025
China Agricultural University
2024-2025
Chongqing Medical University
2025
Children's Hospital of Chongqing Medical University
2025
Ministry of Agriculture and Rural Affairs
2024
Hebei Eye Hospital
2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
Women's Hospital
2020
Zhejiang University
2020
Background and Purpose Short‐chain fatty acids (SCFAs) are metabolites from gut microbes involved in the host's inflammatory response immunity. The aim of this study was to investigate role SCFAs rheumatoid arthritis (RA) possible mechanisms. Experimental Approach Gut microbiota diversity mice analysed by 16S rDNA sequencing. levels were gas chromatography mass spectrometry. T B cells flow cytometry. Bone damage micro‐CT X‐ray. Histopathological status HE staining. Proteins tissues...
Abstract Recurrent Spontaneous Abortion (RSA) is a common pregnancy complication, that has multifactorial causes, and currently, 40%–50% of cases remain unexplained, referred to as Unexplained RSA (URSA). Due the elusive etiology mechanisms, clinical management exceedingly challenging. In recent years, with progress in reproductive immunology, growing body evidence suggests relationship between URSA maternal‐fetal offering hope for development tailored treatment strategies. This article...
Currently, the precise causes of over 40 % recurrent spontaneous abortion (RSA) cases cannot be identified, leading to term "unexplained RSA" (URSA). Through an exploration gut microbiota, metabolites, and immune cell subsets in URSA, this study establishes a link between microbiota-derived metabolites cells. The results indicate reduced diversity microbiota URSA. Targeted metabolomic analyses reveal decreased levels deoxycholic acid (DCA), glycolithocholic (GLCA), acetate, propionate,...
To observe the effect of pharmacist-led antimicrobial stewardship (AMS) on antibiotic exposure for infants with suspected early-onset sepsis (EOS). A retrospective observational study was performed. The pharmacist responsible development, education, and supervision implementation local EOS management protocol. In phase 1, protocol established completely according to latest domestic consensus. 2, updated defined which steps should be taken specific risk factors situations in antibiotics were...
Abstract Gestational trophoblastic tumors seriously endanger child productive needs and the health of women in childbearing age. Nanodrug-based therapy mediated by transporters provides a novel strategy for treatment tumors. Focusing on overexpression human equilibrative nucleoside transporter 1 (ENT1) membrane choriocarcinoma cells (JEG-3), cytarabine (Cy, substrate ENT1)-grafted liposomes (Cy-Lipo) were introduced targeted delivery methotrexate (Cy-Lipo@MTX) this study. ENT1 has high...
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease and its pathogenesis remains unclear. Fibroblast-like synoviocytes (FLSs) play an important role in the of RA. Proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) adaptor protein, which associated with auto-inflammatory disease. In this study, we selected adjuvant-induced (AIA) as animal model to study PSTPIP2 FLSs. We found that expression was significantly down-regulated synovial tissues FLSs AIA rat...