A5100428320- Nanoplatforms for cancer theranostics
- Photonic and Optical Devices
- Nanoparticle-Based Drug Delivery
- Natural Compound Pharmacology Studies
- Advanced Photonic Communication Systems
- Inflammasome and immune disorders
- Optical Network Technologies
- Estrogen and related hormone effects
- Integrated Energy Systems Optimization
- Microfluidic and Capillary Electrophoresis Applications
- Nanofluid Flow and Heat Transfer
- Heme Oxygenase-1 and Carbon Monoxide
- Dendrimers and Hyperbranched Polymers
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Energy Load and Power Forecasting
- Immunotherapy and Immune Responses
- Water resources management and optimization
- PARP inhibition in cancer therapy
- Gout, Hyperuricemia, Uric Acid
- Acute Kidney Injury Research
- Sphingolipid Metabolism and Signaling
- Epigenetics and DNA Methylation
- Electric Power System Optimization
- RNA Interference and Gene Delivery
Tongji Hospital
2006-2025
Huazhong University of Science and Technology
2006-2025
Beijing National Laboratory for Molecular Sciences
2020
Chinese Academy of Sciences
2020
University of Chinese Academy of Sciences
2020
Wuhan National Laboratory for Optoelectronics
2017
North Carolina State University
2008
Shandong Provincial QianFoShan Hospital
2006
Cancer stem cells (CSCs), a rare population in any type of cancers, including colon cancer, are tumorigenic. It has been thought that CSCs responsible for cancer recurrence, metastasis, and drug resistance. Isolating cancers is challenging, thus the molecular mechanism regulating self-renewing differentiation remains unknown. We cultured DLD-1 cells, one types derived from serum-free medium to obtain spheroid cells. These possessed characteristics CSCs, with expression CD133, CD166, Lgr5,...
Pyroptosis is a recently identified form of programmed cell death (PCD) that exerts vital influence on the antitumor immune response. GA, xanthone structure isolated from gamboge resin, naturally occurring bioactive ingredient with several anticancer activities, such as activities affect cycle arrest, apoptosis, and autophagy. Here, we found GA decreased viability CRC lines, HCT116 CT26, in dose- time-dependent manner, multiple pores large bubbles membranes, which are morphological...
SNS-032 is a synthetic compound that specifically inhibits cyclin-dependent kinases 2, 7 and 9. Its primary anticancer activity involves cell cycle arrest, which prevents tumor growth. However, there are limited reports on whether induces pyroptosis, novel inflammation-mediated programmed death pathway in breast cancer (BC). The present study demonstrated treatment decreased viability by inducing pyroptosis BC cells. Typical morphological indications of were observed, including swelling...
Cyclooxygenase-2 (COX-2) is associated with carcinogenesis. The aim of this study was to investigate the expression COX-2 in four hepatocellular carcinoma (HCC) cell lines, and evaluate effect a selective inhibitor, meloxicam, HepG2, high expressing line.Expression detected using RT-PCR, Western blotting immunohistochemical analysis. Cell proliferation measured MTT assay. cycle distribution determined by flow cytometry. Apoptosis TUNEL method. Expression proliferating nuclear antigen (PCNA),...
Cisplatin-paclitaxel (TP) combination chemotherapy as the first-line therapy for numerous cancers is hindered by its inadequate accumulation in tumors and severe side effects resulting from non-specific distribution. The aim of this study to explore whether TMTP1-modified, cisplatin paclitaxel prodrugs co-loaded nanodrug could improve cervical cancer relieve through active passive tumor targeting controlled drug release.TDNP, with capacities release, was prepared co-deliver prodrugs....
The mortality of ovarian cancer (OC) has long been the highest among gynecological malignancies. Although OC is considered to be an immunogenic tumor, effect immunotherapy not satisfactory. immunosuppressive microenvironment one reason for this, and absence recognized effective antigens vaccines another. Chemotherapy, as most commonly used treatment OC, can produce chemotherapy-associated (CAAs) during show in situ vaccine. Herein, we designed antigen capture nano-vaccine NP-TP1@M-M with...
We propose a fast polarization tracking scheme based on phase locking least mean square (LMS) algorithm and experimentally demonstrate it in real-time implementation with quasi-feed-forward digital signal processing (DSP) architecture. It has the advantages of no frequency/phase offset feedback requirement from carrier recovery stage. The performance proposed is verified both simulation coherent transmission systems. can track state (SOP) variations up to 12 Mrad/s 3.3 100-Gb/s QPSK 400-Gb/s...
Aplastic anemia (AA) is characterized as hypoplasia of bone marrow hematopoietic cells and hematopenia peripheral blood cells.Though the supplement exogenous erythropoietin (EPO) has been clinically approved for AA treatment, side-effects hinder its further application.Here a robust treatment induced by chemotherapy drugs explored using gadofullerene nanoparticles (GFNPs).Methods: The were modified with hydrogen peroxide under alkaline conditions to become water-soluble (GFNPs).The...
To compensate the delay skew and imbalance for received signals, we realize a real-valued equalizer in 10-Gb/s real-time PDM-QPSK coherent systems. It shows better performance than conventional complex-valued with only small resources consumptions increase.
Abstract M1 macrophage, characterized by the production of proinflammatory cytokines, has been reported to exert a critical role in ischemia-reperfusion (I/R)-induced acute kidney injury (AKI). Recently, increasing evidence suggests that aerobic glycolysis plays an important polarization macrophages. However, area still needs continuous studies although it developed lot. Here, we found upregulation ubiquitin-specific protease 25 (USP25), deubiquitinase, was correlated with renal function...