The underlying mechanisms by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to and long-term neurological manifestations remains obscure. We aimed characterize the neuropathological changes in patients with disease 2019 determine pathophysiological mechanisms. In this autopsy study of brain, we characterized vascular pathology, neuroinflammatory cellular humoral immune responses immunohistochemistry. All died during first wave pandemic from March July 2020. were...

To determine whether there is activation of human endogenous retrovirus K (HERV-K) in amyotrophic lateral sclerosis HIV infection and it might respond to treatment with antiretroviral drugs.In this case series, we present 5 patients who subsequently developed motor neuron disease involving both upper lower neurons. We monitored HERV-K levels plasma 4 these patients.Three received therapy had reversal symptoms within 6 months onset neurologic the other 2 slow progression over several years....

Real-world image dehazing remains a challenging task due to the diverse nature of haze degradation and lack large-scale paired datasets. Existing methods based on hand-crafted priors or generative struggle recover accurate backgrounds fine details from dense regions. In this work, we propose novel paradigm, PromptHaze, for real-world via depth prompt Depth Anything model. By employing prompt-by-prompt strategy, our method iteratively updates progressively restores background through network...

The application of shear wave elastography (SWE) in assessment the musculoskeletal system is affected by various factors. This study aimed to explore influence machines, probes, region interest (ROI) sizes, and acquisition angles on muscle speed (SWS).The SWS ex vivo isolated muscles were acquired using 3 different machines (Aixplorer system, SuperSonic Imagine; Acuson S3000, Siemens Healthcare; Resona 7, Mindray) 2 linear probes SL 10-2 15-4). Also, 4 ROI sizes (diameter 1-10 mm) 9 (0-40°)...

Subgroup J avian leukemia virus (ALV-J) and chicken infectious anemia (CIAV) are widely acknowledged as significant immunosuppressive pathogens that commonly co-infect chickens, causing substantial economic losses in the poultry industry. However, whether co-infection of ALV-J CIAV have synergistic pathogenicity remains uncertain. To explore their pathogenesis, we established a model HD11 cells specific-pathogen-free (SPF) chickens. We discovered can synergistically promote secretion IL-6,...

Shear wave elastography is a promising method to diagnose early musculoskeletal lesions. We aimed explore the feasible depth and acceptable precompression applied by probe couplant for soft tissues in present system.Ex-vivo muscles were evaluated at depths of 0.5-6 cm 3 operators, using 1-5 mm thickness 0-3.0 kPa pressure. compared shear speed (SWS) used intraclass correlation coefficients assess reproducibility. In vivo skin subcutaneous superficial fascia from volunteers tested ranging...

In recent years, superinfections of avian leukosis virus subgroup J (ALV-J) and infectious bursal disease (IBDV) have been frequently observed in nature, which has led to the increasing virulence infected chickens. However, reason for enhanced pathogenicity remained unclear. this study, we demonstrated an effective candidate model studying outcome with ALV-J IBDV cells specific-pathogen-free (SPF) chicks. Through vitro experiments, found that can establish superinfection models...

To explore the influence of surrounding environment target tissue, lesion size, and rectangular sampling box size on shear wave speed (SWS).The tendon SWS was acquired ex-vivo. Then tendons were dissected buried in couplant (gel) evaluated by two-dimensional elastography (2D-SWE). Finally, placed isolated muscles to simulate intramuscular lesions, their elasticity tested under two conditions. The complete liver acquired. Similarly, large small pieces livers cut out, muscles, assessed SWE...

There are no representative studies on the mental health status of persons with disabilities in China.Estimate prevalence depressive symptoms and identify factors associated a sample individuals serious visually Wuhan, China.A multi-stage stratified cluster sampling method was used to 1200 disabled from among 22,000 visual who were registered Wuhan Disabled Persons' Federation. Identified administered Center for Epidemiological Studies Depression Scale (CES-D) Revised Eysenck Personality...

Viscoelasticity is an essential feature of nerves, although little known about their viscous properties. The discovery shear wave dispersion (SWD) imaging has presented a new approach for the non-invasive evaluation tissue viscosity. present study investigated feasibility using SWD to evaluate diabetic neuropathy sciatic nerve in rat model.This included 11 rats group and 12 healthy control group. Bilateral nerves were evaluated 3 months after treatment with streptozotocin. We measured...

Osteoarthritis is a chronic degenerative disease with an incidence of 50% in people over 65 years old and 80% 80 worldwide. It the second leading reason loss working capacity after cardiovascular diseases severely affects society families. Therefore, finding biological markers related to diagnosis treatment osteoarthritis great significance clinical practice.To observe changes value serum inflammatory factors miR-145 expression patients before treatment.Eighty-three knee (observation group)...

Hepatic acute graft-versus-host disease (aGVHD) is a major life-threatening complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). We hypothesized that contrast-enhanced ultrasound (CEUS) could serve as new imaging biomarker in early diagnosis hepatic aGVHD by detecting liver microcirculation.Thirty Wistar rats received allo-HSCT were finally included after excluding 9 rats, and they randomly divided into 5 groups (1- to 5-week groups, 6 per group). Six used for the...

Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by high relapse. Therefore, the present study aimed to investigate ultrasonographic features of contrast-enhanced ultrasonography (CEUS) in sacroiliac joint (SIJ) patients with AS remission after discontinuation anti-tumor necrosis factor (TNF) therapy, and also examined role CEUS predicting relapse.In this prospective observational study, 130 SIJs 65 (according modified New York criteria) satisfying Spondylitis...

Our study investigates the feasibility of using quantitative evaluation for nerve entrapment visualization by shear wave elastography (SWE) in diabetic rats.A total 24 male Sprague-Dawley (SD) rats were included this study. Before injection streptozotocin (STZ), experimental groups assigned as compression (DNC) group (DNC, n=18) and control (CON, n=6). The DNC model was created wrapping a silicone tube around nerve, then divided into 2-week (DNC2W, n=6), 4-week (DNC4W, 8-week (DNC8W, n=6)...

To investigate the efficacy of 135° hip screw, 95° intramedullary screw (IMHS) and in treatment intertrochanteric reverse dip fracture femur.We retrospectively analyzed 125 matched pairs human femurs (median age 64 years) which were osteotomized at a 33° angle left femur extended downward from minor trochanter to simulate oblique fracture. The right served as control. (n=4) was implanted with or IMHS. A strain detector placed distal site monitor fragment strain. lateral displacement proximal...

To investigate the feasibility of using shear wave dispersion (SWD) imaging to evaluate hepatic acute graft-versus-host disease (aGVHD) in a rat model.To establish an aGVHD model, 30 Wistar rats were subjected bone marrow transplantation, 10 Fischer 344 used as donors, and 6 control group. Each week, randomly chosen divided into groups 1 week (1 w) 5 weeks (5 w). For each subgroup, received clinical index assessment examination with 2 quantitative values, (SW) speed SWD slope. The...

Viral co-infections pose significant challenges, causing substantial economic losses worldwide in the poultry industry. Among these, avian lLeukosis virus subgroup J (ALV-J) and chicken infectious anemia (CIAV) are particularly concerning, as they frequently lead to chickens, further compromising their immune defenses, increasing susceptibility secondary infections diminishing vaccine efficacy. While our previous studies have examined pathogenicity immunosuppressive effects of these vitro...