A5100419497- Endoplasmic Reticulum Stress and Disease
- Hippo pathway signaling and YAP/TAZ
- Fish Biology and Ecology Studies
- Aldose Reductase and Taurine
- Cancer, Hypoxia, and Metabolism
- Galectins and Cancer Biology
- Caveolin-1 and cellular processes
- Biochemical effects in animals
- Parasitic Infections and Diagnostics
- Protein Degradation and Inhibitors
- Lipid metabolism and biosynthesis
- Amoebic Infections and Treatments
- Cancer Cells and Metastasis
- Toxoplasma gondii Research Studies
- Nerve injury and regeneration
- TGF-β signaling in diseases
- Coastal and Marine Management
- GABA and Rice Research
- Porphyrin Metabolism and Disorders
- Groundwater and Isotope Geochemistry
- Earthquake Detection and Analysis
- Autophagy in Disease and Therapy
- Machine Learning in Materials Science
- Proteoglycans and glycosaminoglycans research
- Wnt/β-catenin signaling in development and cancer
Ministry of Ecology and Environment
2024
Zunyi Medical University
2022-2024
National Institute of Biological Sciences, Beijing
2019-2024
Affiliated Hospital of Guizhou Medical University
2023
Hainan Normal University
2022
Shenyang Agricultural University
2021
Huzhou University
2019-2020
Shanghai East Hospital
2019
Shanxi University
2019
Beijing University of Chinese Medicine
2018
Abstract Hypoxia and the hypovascular tumor microenvironment are major hallmarks of pancreatic ductal adenocarcinoma (PDAC), in which glycolysis is great importance to survival proliferation. There little research regarding role Nuclear Factor Activated T Cells 5 (NFAT5) relation carcinoma. Here, we explored impact NFAT5 on biological behavior PDAC underlying mechanism. We demonstrated that was highly expressed related poorer prognosis. Knockdown lead impaired proliferation cells caused by...
Carcinoma-associated fibroblasts (CAFs) are critical in determining tumor invasion and metastasis. However the role of CAFs salivary gland adenoid cystic carcinoma (ACC) is poorly understood. In this study, we isolated primary from two ACC patients. ACC-derived expressed typical CAF biomarkers showed increased migration activity. Conditioned medium collected significantly promoted cell invasion. Co-culture with cells a microfluidic device further revealed that localized at front followed...
ABSTRACT Although the Hippo–yes-associated protein (Yap) pathway has been implicated in lung development, specific roles for Yap and its nucleocytoplasmic shuttling developing airway alveolar compartments remain elusive. Moreover, conflicting results from expression studies differences phenotypes of Hippo kinase null mutants caused controversy over dynamics significance subcellular localization lung. Here, we show that aberrant morphogenesis Yap-deficient lungs disruption developmental...
Quantitative Loop-mediated isothermal amplification (qLAMP) is a relatively new method that has gained popularity in recent years, particularly disease identification, including during the SARS-CoV-2 pandemic. Unlike conventional quantitative PCR (qPCR), qLAMP features linear phase before exponential phase. Determining cycle threshold (Ct) values through automatic thresholding may therefore produce inaccurate results, and nature of these thresholds complicates comparability between studies...
Peptides from sesame cake (PSC) have been reported to exert a beneficial effect on aging. Parkinson's disease (PD) is an age-related disorder, which manifests as Lewy body formation and dopaminergic dysfunction. To investigate the effects of PSC PD-associated pathologies identify possible underlying molecular mechanisms, this study employed two transgenic Caenorhabditis elegans models: NL5901, expressed α-synuclein (α-syn) in muscle cells, BZ555, GFP dopamine neuronal soma axons. The results...
Nasopharyngeal carcinoma (NPC) is a head and neck malignant tumor rare throughout most of the world but common in Southeast Asia, especially Southern China. Flotillin-2 (Flot-2) not only an important component cellular membrane, also involves various processes such as membrane trafficking, T cell B activation, regulation several signaling pathways associated with growth transformation, keeping structure junction epidermal cells formation filopodia. Although molecular effects Flot-2 have been...
Cardiac macrophages with different polarization phenotypes regulate ventricular remodeling and neovascularization after myocardial infarction (MI). Annexin A2 (ANXA2) promotes macrophage to the repair phenotype regulates neovascularization. However, whether ANXA2 plays any role in post-MI its underlying mechanism remains obscure. In this study, we observed that expression levels of were dynamically altered mouse hearts upon MI peaked on second day post-MI. Using adeno-associated virus...
Crab-eating frogs (Fejervarya cancrivora) can live in brackish water with a salinity of up to 18‱, although most amphibians are not able tolerate such high saline environments. To investigate its potential osmoregulation, we conducted experiments F. cancrivora and multistriata. The results showed that made use ions (such as Na+ Cl−) increase intracellular concentrations via the Na+/K+-ATPase (NKA) enzyme. mRNA expression aldose reductase (AR) was significantly higher (p < 0.05), indicating...
No any effective treatments can prevent from the motor neuron degeneration in amyotrophic lateral sclerosis (ALS) at present.In order to modulating endogenous neural precursor cells (NPCs) repairing degenerative neurons ALS, we studied alteration of vimentin-containing NPCs olfactory bulb (OB) different stages SOD1 wlid-type and G93A transgenic mice.The results showed that (VCCs) were mainly distributed glomerular layer (Gl), accessory OB (AOB), core, granular cell (GRO) mitral (MI)+the...
Abstract Targeted protein degradation (TPD) has emerged as an effective strategy to eliminate disease-causing proteins by inducing their interactions with the machinery. First-generation TPD agents exploit a limited set of broadly expressed E3 ubiquitin ligases constitutive activity, forbidding application requiring higher levels targeting selectivity. Here, phenotype-based screening, we discovered that antipsychotic drug acepromazine possesses interferon-enhanced cytotoxicity towards cancer...
Abstract The importance of infaunal bioturbators for the functioning marine ecosystems cannot be overstated. Inhabitants estuarine and coastal habitats are expected to show resilience fluctuations in seawater temperature pH, which adds complexity our understanding effects global change drivers. Further, stress responses may propagated through chemical cues within across species, amplify costs life alter species interactions. Research into molecular mechanisms underlying this has been limited...
BackgroundAlzheimer's disease (AD) is a common neurodegenerative with age-related, which accounts for nearly 80% of dementia.Accompanied aging population worldwide and clinical failures in AD drugs, early prevention diagnosis are under main concern.Traditional Chinese medicine (TCM) has long history the cognition declines.In clinic, combination geniposide Panax notoginseng saponin (PNS) clinically e cacious treatment ischemic cerebral stroke vascular dementia.In vivo, preventive strategy,...