A5007005285- Ecology and Vegetation Dynamics Studies
- Mycorrhizal Fungi and Plant Interactions
- Forest Ecology and Biodiversity Studies
- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Biological Control of Invasive Species
- Allelopathy and phytotoxic interactions
- Plant Parasitism and Resistance
- Seedling growth and survival studies
- Plant and animal studies
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- Legume Nitrogen Fixing Symbiosis
- Soil Carbon and Nitrogen Dynamics
- Rangeland and Wildlife Management
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Genetics, Bioinformatics, and Biomedical Research
- Fire dynamics and safety research
- Reproductive System and Pregnancy
- Botany and Plant Ecology Studies
- RNA modifications and cancer
U-M Rogel Cancer Center
2024
University of Michigan–Ann Arbor
2024
Michigan Center for Translational Pathology
2024
University of California, Santa Cruz
2012-2021
Northern Arizona University
2017-2019
University of California System
2009-2015
Summary An increasingly recognized impact of plant invaders is the disruption positive interactions between native plants and their belowground mutualistic mycorrhizal fungi. We reviewed 112 studies from 61 publications that report invader impacts on describe emerging patterns frequency negative, neutral effects fungal abundance, richness community composition, we evaluate how these outcomes vary with invasion age. also evidence for three mechanisms disruption: (1) plant‐plant competition...
Immune tolerance mechanisms are shared in cancer and pregnancy. Through cross-analyzing single-cell RNA-sequencing data from multiple human types the maternal-fetal interface, we found B7-H4 (VTCN1) is an onco-fetal immune checkpoint. We showed that genetic deficiency of resulted activation fetal resorption allogeneic pregnancy models. Analogously, contributed to MPA/DMBA-induced breast progression, accompanied by CD8
Immune checkpoint blockade (ICB) triggers tumor ferroptosis. However, most patients are unresponsive to ICB. Tumors might evade ferroptosis in the microenvironment (TME). Here, we discover SLC13A3 is an itaconate transporter cells and endows resistance, diminishing immunity ICB efficacy. Mechanistically, uptake via from tumor-associated macrophages (TAMs), thereby activating NRF2-SLC7A11 pathway escaping immune-mediated Structural modeling molecular docking analysis identify a functional...
Summary Impacts of invasive species may change in magnitude and even direction with invasion age. could increase as the population increases, individuals grow size ecological changes accumulate. We used a chronosequence approach to characterize development soil impacts over time following Cytisus scoparius , widespread nitrogen‐fixing shrub thought limit reforestation success. In greenhouse experiment, we evaluated how abundance ectomycorrhizal fungi, Douglas‐fir performance leaf nitrogen...
Abstract Reforestation is challenging when timber harvested areas have been degraded, invaded by nonnative species, or are of marginal suitability to begin with. Conifers form mutualistic partnerships with ectomycorrhizal fungi ( EMF ) obtain greater access soil resources, and these may be especially important in degraded areas. However, harvest can impact mycorrhizal removing compacting topsoil, host plants, warming drying the soil. We used a field experiment evaluate role Douglas‐fir...
Abstract We conducted a large-scale, multiple-year study in harvested areas of Douglas-fir ( Pseudotsuga menziesii [Mirbel] Franco) forests western Washington, examining the effectiveness control methods on widespread invasive shrub Scotch broom [ Cytisus scoparius (L.) Link]. tested both chemical and physical methods, using three different approaches that are management relevant: (1) triclopyr, POST herbicide, at times year different-sized plants; (2) cutting (or brushcutting) mature...
<div>Abstract<p>Mutations in IFN and MHC signaling genes endow immunotherapy resistance. Patients with colorectal cancer infrequently exhibit gene mutations are generally resistant to immunotherapy. In exploring the integrity of cancer, we found that optineurin was a shared node between two pathways predicted patient outcome. Loss occurs early-stage human cancer. Immunologically, deficiency shown attenuate IFNGR1 MHC-I expression, impair T-cell immunity, diminish efficacy murine...
<p>Supplementary Figure S1-9 and Supplementary Tables S1-8</p>
<div>Abstract<p>Mutations in IFN and MHC signaling genes endow immunotherapy resistance. Patients with colorectal cancer infrequently exhibit gene mutations are generally resistant to immunotherapy. In exploring the integrity of cancer, we found that optineurin was a shared node between two pathways predicted patient outcome. Loss occurs early-stage human cancer. Immunologically, deficiency shown attenuate IFNGR1 MHC-I expression, impair T-cell immunity, diminish efficacy murine...
<p>Supplementary Figure S1-9 and Supplementary Tables S1-8</p>
Author(s): Parker, Ingrid M.; Holloran, Pete; Swope, Sarah Cummings, Justin; Grove, Sara; Fresquez, Carla