A5005076655- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Chemical Synthesis and Analysis
- COVID-19 Clinical Research Studies
- Cell Adhesion Molecules Research
- Viral Infectious Diseases and Gene Expression in Insects
- SARS-CoV-2 detection and testing
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Glycosylation and Glycoproteins Research
- Click Chemistry and Applications
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- vaccines and immunoinformatics approaches
- Chronic Lymphocytic Leukemia Research
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Advanced Biosensing Techniques and Applications
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Protein purification and stability
- Virus-based gene therapy research
Brown Foundation
2022-2024
Institute of Molecular Medicine
2024
The University of Texas Health Science Center at Houston
2023-2024
Institute of Biostructure and Bioimaging
2020-2023
Akebia Therapeutics (United States)
2019-2020
University of Delhi
2016
Immune checkpoint blockade (ICB) triggers tumor ferroptosis. However, most patients are unresponsive to ICB. Tumors might evade ferroptosis in the microenvironment (TME). Here, we discover SLC13A3 is an itaconate transporter cells and endows resistance, diminishing immunity ICB efficacy. Mechanistically, uptake via from tumor-associated macrophages (TAMs), thereby activating NRF2-SLC7A11 pathway escaping immune-mediated Structural modeling molecular docking analysis identify a functional...
Pt(<sc>ii</sc>)-based linkers re-bridge the antibody chains<italic>via</italic>strong Pt–S interaction thereby imparting homogeneity, site-specificity and stability to antibody–drug conjugate.
Bicyclic peptides assembled around small organic scaffolds are gaining an increasing interest as new potent, stable and highly selective therapeutics because of their uncommon ability to specifically recognize protein targets, size that favor tissue penetration the versatility easiness synthesis. We have here rationally designed bicyclic a common tri-bromo-methylbenzene moiety in order mimic structure CFC domain oncogene Cripto-1 and, more specifically, orient most fruitful way hot spot...
Background: Monoclonal antibodies (mAbs) against cancer biomarkers are key reagents in diagnosis and therapy. One such relevant biomarker is a preferentially expressed antigen melanoma (PRAME) that selectively many tumors. Knowing mAb’s epitope of utmost importance for understanding the potential activity therapeutic prospective reagents. Methods: We generated mAb PRAME immunizing mice with fragment 161–415; affinity antibody protein was evaluated by ELISA SPR, its ability to detect cells...
The capacity of SARS-CoV-2 to evolve poses challenges conventional prevention and treatment options such as vaccination monoclonal antibodies, they rely on viral receptor binding domain (RBD) sequences from previous strains. Additionally, animal CoVs, especially those the SARS family, are now appreciated a constant pandemic threat. We present here new antiviral approach featuring inhalation delivery recombinant trap composed ten copies angiotensin-converting enzyme 2 (ACE2) fused IgM Fc....
Abstract Glioblastoma (GBM) is the most aggressive, malignant, primary brain tumor with abysmal overall survival. GBM regarded as an “immune cold” due to poor immune cell infiltration and immunosuppressive signaling in microenvironment (TME). Oncolytic herpes virus (oHSV) therapy has emerged a possible therapeutic avenue for solid tumors such GBM. We have observed that oHSV-treated cells release extracellular ATP (eATP) which functions immunostimulatory molecule. In TME, eATP rapidly...
Drug development in recent years is increasingly focused on developing personalized treatments based blocking molecules selective for therapeutic targets specifically present individual patients. In this perspective, the specificity of and agents plays a crucial role. Monoclonal antibodies (mAbs) their surrogates are used context thanks to ability bind inhibit activity or transport bioactive into compartments which expressed. Small antibody-like molecules, such as Fabs, often certain...
Abstract The capacity of SARS-CoV-2 to evolve poses challenges conventional prevention and treatment options such as vaccination monoclonal antibodies, they rely on viral receptor binding domain (RBD) sequences from previous strains. Additionally, animal CoVs, especially those the SARS family, are now appreciated a constant pandemic threat. We present here new antiviral approach featuring inhalation delivery recombinant trap composed ten copies angiotensin-converting enzyme 2 (ACE2) fused...