A5069143625- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- RNA Research and Splicing
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- Hippo pathway signaling and YAP/TAZ
- Cell Adhesion Molecules Research
- dental development and anomalies
- Developmental Biology and Gene Regulation
- Nuclear Receptors and Signaling
- Cutaneous Melanoma Detection and Management
- Cellular Mechanics and Interactions
- Axon Guidance and Neuronal Signaling
- 14-3-3 protein interactions
- Chemical Synthesis and Analysis
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
Midwestern University
2018-2022
University of Arizona
2012
Background Recently, MicroRNAs (miR) and AMP-kinase (AMPK) have emerged as prominent players in the development of cardiac hypertrophy heart failure. We hypothesized that components adenosine monophosphate-activated kinase pathway are targeted by miRs alter AMPK signaling during pathological stress. Methodology/Principal Findings Using a mouse model hypertrophic cardiomyopathy (HCM), we demonstrated early elevation miR-195 miR-451 HCM hearts, which targets MO25, central component...
Bicyclic peptides assembled around small organic scaffolds are gaining an increasing interest as new potent, stable and highly selective therapeutics because of their uncommon ability to specifically recognize protein targets, size that favor tissue penetration the versatility easiness synthesis. We have here rationally designed bicyclic a common tri-bromo-methylbenzene moiety in order mimic structure CFC domain oncogene Cripto-1 and, more specifically, orient most fruitful way hot spot...
Oral squamous cell carcinoma (OSCC) is a common epithelial malignancy of the oral cavity. Nodal and Cripto-1 (CR-1) are important developmental morphogens expressed in several adult cancers associated with disease progression. Whether CR-1 simultaneously same tumor how this affects cancer biology unclear. We investigate expression potential role both human OSCC. Immunohistochemistry results show that OSCC sample intensity staining correlated advanced-stage disease. However, was not observed...
Netrin-1 is a neural guidance factor that regulates migration and positioning of crest-derived cells during embryonic development. Depending on the type receptor expression, are either attracted or repulsed by Netrin-1. Postnatal expression detected in brain, colon, liver, kidney, which common sites cancer metastasis, including melanoma. Thus, understanding dynamics between its receptors could explain attraction melanoma towards these Netrin-1-expressing tissues. Here, we investigate whether...
Melanoma is a lethal form of skin cancer triggered by genetic and environmental factors. Excision early-stage, poorly aggressive melanoma often leads to successful outcome; however, left undiagnosed these lesions can progress metastatic disease. This research investigates whether the exposure certain normal cells explain how non-metastatic becomes more while still confined skin. To this end, we used serial co-culture approach sequentially expose from two different, human cell lines against...
Presenilin-1 (PS-1), a component of the gamma (γ)-secretase catalytic complex, has been implicated in Alzheimer's disease (AD) and tumorigenesis. Interestingly, AD risk is inversely related to melanoma, suggesting that AD-related factors, such as PS-1, may affect melanomagenesis. PS-1 shown reduce Wnt activity by promoting degradation beta-catenin (β-catenin), an important signaling partner. Since known enhance progression different cancers, including we hypothesized could Wnt-associated...
Objectives: MicroRNAs (miRs) have been identified as chief post-transcriptional regulators of cardiac disease progression. In addition, a critical role the adenosine monophosphate-activated kinase (AMPK) pathway in development myocardial hypertrophy has revealed. Yet, regulation AMPK by miRs heart not addressed. We hypothesized that components are targeted and alter signaling mouse model hypertrophic cardiomyopathy (HCM). Methods results: Using real-time PCR, candidate miR screen included 22...
Abstract The diagnosis of melanoma is increasing and current therapies for advanced disease remain unsuccessful. Thus, research aimed at developing novel targeting approaches needed. Cripto-1 (CR-1), an epidermal growth factor (EGF)-like developmental morphogen, functions as a co-receptor the tumor (TGF)-beta related molecule, Nodal. CR-1/Nodal signaling pathways can induce cell survival, proliferation migration cancer cells. Studies have shown that Nodal expressed high levels in melanoma....