A5044034325- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Gene expression and cancer classification
- Lung Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cervical Cancer and HPV Research
- Molecular Biology Techniques and Applications
- Renal cell carcinoma treatment
- Genetic Mapping and Diversity in Plants and Animals
- Protein Kinase Regulation and GTPase Signaling
- Quinazolinone synthesis and applications
- Melanoma and MAPK Pathways
- Renal and related cancers
- Acute Myeloid Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Blood groups and transfusion
- Musculoskeletal synovial abnormalities and treatments
- Clinical Laboratory Practices and Quality Control
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Vascular Tumors and Angiosarcomas
Loyola University Medical Center
2016-2022
North Shore Hospital
2022
University of Chicago
2020-2021
Kuwait Institute for Medical Specialization
2019
Versiti Blood Center of Wisconsin
2017
Medical College of Wisconsin
2014-2017
Baylor College of Medicine
2016
Stony Brook University
2016
State University of New York
2016
Yale University
2016
Tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) produce objective responses in a minority patients with advanced-stage non-small cell lung cancer (NSCLC), and about half all treated progress within 6 weeks instituting therapy. Because target these agents is known, it should be possible to develop biological predictors response, but EGFR protein levels have not been proven useful as predictor TKI response mechanism primary resistance unclear. We used microarray...
Abstract Mitogen‐activated protein kinases (MAPKs) are regulated by MAPK (MKKs), which in turn MKK (MKKKs). While a single MKKK can regulate several different family members, and MKKKs often activate the same MAPK, emerging evidence indicates unique role for individual acting as signaling nodes to coordinately subsets of MAPKs response specific cellular stimuli. Thus, while there is much apparent overlap regulation MKKKs, each serves purpose functions. The this study was define MEKK2, an...
Abstract Background With the advent of "omics" (e.g. genomics, transcriptomics, proteomics and phenomics), studies can produce enormous amounts data. Managing this diverse data integrating with other biological are major challenges for bioinformatics community. Comprehensive new tools needed to store, integrate analyze efficiently. Description The PhenoGen Informatics website http://phenogen.uchsc.edu is a comprehensive toolbox storing, analyzing microarray related genotype phenotype site...
Pure erythroid leukemia (PEL) is a rare type of acute myeloid (AML) with very aggressive clinical course. Presentation as myeloid/erythroid sarcoma exceedingly rare. We describe an infantile PEL presenting multifocal sarcoma, clinically and pathologically mimicking Ewing sarcoma/PNET family tumors. The patient died 8 weeks after the initial presentation due to widespread disease. Our case shows that needs be considered in differential diagnosis small round blue cell tumors infancy. A...
Background Body fluid cytology (BFC) is an important tool in the diagnosis and staging of malignancy aided by judicious use immunohistochemistry (IHC). The aim this study was to determine usage rates IHC stains BFC, their type indications, diagnostic impact. We also attempted estimate optimal rate BFC comparing entire laboratory's each individual cytopathologist's with respective indeterminate malignant rates. Methods conducted a retrospective stain during 5.5‐year interval (2013‐2018)...
Endolymphatic sac tumor (ELST) is a rare neoplasm arising in the temporal petrous region thought to originate from endolymphatic epithelium. It may arise sporadically or association with Von-Hippel-Lindau syndrome (VHL). The ELST prevalence VHL ranges 3 16% and be initial presentation of disease. Onset usually 3rd 5th decade hearing loss an indolent course. ELSTs present as locally destructive lesions characteristic computed tomography imaging features. Histologically, they show papillary,...
Warthin‐Finkeldey type giant cells were first described in autopsies performed on young children who died during the highly lethal measles epidemic Palermo winter of 1908. The had 8‐15 nuclei without identifiable cytoplasm within germinal centers lymphoid organs resembling megakaryocytes. We describe a case Hashimoto thyroiditis with an enlarging substernal throid mass. resection specimen contained many Warthin‐Finkeldey‐Like Cells (WFLC) extranodal marginal zone lymphoma (MALT type) focal...
Background At times, distinguishing Bowen disease (BD) and benign seborrheic keratosis (SK) is histologically challenging, especially when SK shows clonal features (clonal [CSK]). While p16 often reported as positive in BD negative SK, expression CSK rarely studied. Here we investigate immunohistochemistry CSK, BD. Methods with pattern of was noted for 14 12 18 The degree inflammation among lesions respect to also noted. Results When examining staining nests 57% showed diffuse or...
7027 Background: Gefitinib (Iressa) and other EGFR inhibitors are active in 12–19% of NSCLC patients previously treated with chemotherapy. Currently, there no selection criteria for determining which will benefit from this treatment. expression does not predict sensitivity. Using a panel cell lines varying sensitivity to we defined biomarkers that or resistance. Methods: was determined 18 using MTT assays. Cell were classified as sensitive (IC50<1μM), resistant (IC50>10μM) intermediate (IC50...
<b><i>Background:</i></b> Fine needle aspiration (FNA) of renal masses can distinguish between benign and malignant neoplasms in 73–94% cases. Previous studies suggested the correct subclassification cell carcinomas (RCCs) by cytomorphology be achieved up to 80% However, as RCCs become increasingly subclassified molecular signatures, based on cytology alone is difficult. <b><i>Design:</i></b> Two FNA passes (2 stained with Diff-Quik® 2...
7027 Background: Gefitinib (Iressa) and other EGFR inhibitors are active in 12–19% of NSCLC patients previously treated with chemotherapy. Currently, there no selection criteria for determining which will benefit from this treatment. expression does not predict sensitivity. Using a panel cell lines varying sensitivity to we defined biomarkers that or resistance. Methods: was determined 18 using MTT assays. Cell were classified as sensitive (IC50<1μM), resistant (IC50>10μM) intermediate (IC50...
Abstract Phyllodes tumors (PTs) pose a significant diagnostic challenge in breast pathology as histological criteria and cutoffs for grading are complex arbitrary. Nevertheless, the clinical behavior of PTs varies widely correlates, part, with grade. Methylation signatures have gained interest prognostic tools variety neoplasms. In particular, 5-hydroxymethylcytosine (5-hmC) has been found to be useful biomarker. Herein, we assess 51 varying grades 15 cellular fibroadenomas (cFA) stromal...
The availability of complete genomes and global gene expression profiling has greatly facilitated analysis complex genetic regulatory systems. We describe the use a bioinformatics strategy for analyzing cis-regulatory design genes diferentially regulated during viral infection target cell. large-scale transcriptional activity human embryonic kidney (HEK293) cells to reovirus (serotype 3 Abney) was measured using Affymetrix HU- 95Av2 array. Comparing 2000 base pairs 5 upstream sequence most...
The authors do not have any conflict of interest relevant to this article.
A 62-year-old male with a past medical history of orthotopic heart transplant in 1995, hypertension, ulcerative colitis, prostate cancer (5 years prior to the current episode) treated radiotherapy, hyperlipidemia, and type 2 diabetes mellitus presented April 2011 for evaluation left knee drainage, sore throat, multiple skin lesions. His throat had started several weeks before was associated dry cough, low-grade fever, intermittent chills. The patient denied recent contact persons suffering...
Answer: Alternaria spp. A calcofluor white staining was performed on the synovial fluid sample next day to help in identification of possible causal pathogen. The fluorescent stain showed many true septate hyphae (see Fig. S1 supplemental material) that had been missed