A5037794387- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Computational Drug Discovery Methods
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Adipose Tissue and Metabolism
- Mathematical Biology Tumor Growth
- Cancer-related molecular mechanisms research
- Radiation Therapy and Dosimetry
- Mitochondrial Function and Pathology
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Pharmacogenetics and Drug Metabolism
- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- RNA modifications and cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Estrogen and related hormone effects
- Immunotherapy and Immune Responses
- PARP inhibition in cancer therapy
- Virus-based gene therapy research
- Metabolism, Diabetes, and Cancer
- Animal Genetics and Reproduction
Columbia University
2022-2024
Columbia University Irving Medical Center
2021-2023
Mitochondria provide the first line of defense against tumor-promoting effects oxidative stress. Here we show that prostate-specific homeoprotein NKX3.1 suppresses prostate cancer initiation by protecting mitochondria from Integrating analyses genetically engineered mouse models, human cells, and organotypic cultures, find that, in response to stress, is imported via chaperone protein HSPA9, where it regulates transcription mitochondrial-encoded electron transport chain (ETC) genes, thereby...
Abstract Prioritizing treatments for individual patients with cancer remains challenging, and performing coclinical studies using patient-derived models in real time is often unfeasible. To circumvent these challenges, we introduce OncoLoop, a precision medicine framework that predicts drug sensitivity human tumors their preexisting high-fidelity (cognate) model(s) by leveraging perturbation profiles. As proof of concept, applied OncoLoop to prostate genetically engineered mouse (GEMM)...
Abstract To study the progression of bladder cancer from non–muscle-invasive to muscle-invasive disease, we have developed a novel toolkit that uses complementary approaches achieve gene recombination in specific cell populations urothelium vivo, thereby allowing us generate new series genetically engineered mouse models (GEMM) cancer. One method is based on delivery adenoviruses express Cre recombinase selected types urothelium, and second transgenic drivers which activation inducible...
Although localized prostate cancer is relatively indolent, advanced manifests with aggressive and often lethal variants, including neuroendocrine (NEPC). To identify drivers of cancer, we leveraged
Abstract At present, prioritizing cancer treatments at the individual patient level remains challenging, and performing co-clinical studies using patient-derived models in real-time is often not feasible. To circumvent these challenges, we introduce OncoLoop, a precision medicine framework to predict validate drug sensitivity human tumors their pre-existing high-fidelity ( cognate ) model(s) by leveraging perturbational profiles of clinically-relevant oncology drugs. As proof-of-concept,...
<div>Abstract<p>To study the progression of bladder cancer from non–muscle-invasive to muscle-invasive disease, we have developed a novel toolkit that uses complementary approaches achieve gene recombination in specific cell populations urothelium <i>in vivo</i>, thereby allowing us generate new series genetically engineered mouse models (GEMM) cancer. One method is based on delivery adenoviruses express Cre recombinase selected types urothelium, and second transgenic...
<p>Video of mouse procedures for post-surgical steps</p>
<p>Video of mouse procedures for post-surgical steps</p>
<p>Video of mouse procedures for intravesical delivery 4-hydroxy tamoxifen into bladder</p>
<p>Video of mouse procedures for intravesical delivery 4-hydroxy tamoxifen into bladder</p>
<p>Video of mouse surgical procedures for transurethral delivery Adenovirus to bladder</p>
<p>Supplementary of differential gene expression and pathway analyses</p>
<p>Detailed procedures to accompany the videos</p>
<p>Video of mouse surgical procedures for delivery Adenovirus into the bladder lumen.</p>
<p>This file contains an index of all supplementary materials, and the figures, legends, tables.</p>
<p>Video of mouse surgical procedures for transurethral delivery Adenovirus to bladder</p>
<p>Supplementary of differential gene expression and pathway analyses</p>
<p>Detailed procedures to accompany the videos</p>
<p>Video of mouse surgical procedures for delivery Adenovirus into the bladder lumen.</p>
<p>This file contains an index of all supplementary materials, and the figures, legends, tables.</p>
<div>Abstract<p>Mitochondria provide the first line of defense against tumor-promoting effects oxidative stress. Here we show that prostate-specific homeoprotein NKX3.1 suppresses prostate cancer initiation by protecting mitochondria from Integrating analyses genetically engineered mouse models, human cells, and organotypic cultures, find that, in response to stress, is imported via chaperone protein HSPA9, where it regulates transcription mitochondrial-encoded electron transport...
<div>Abstract<p>Prioritizing treatments for individual patients with cancer remains challenging, and performing coclinical studies using patient-derived models in real time is often unfeasible. To circumvent these challenges, we introduce OncoLoop, a precision medicine framework that predicts drug sensitivity human tumors their preexisting high-fidelity (cognate) model(s) by leveraging perturbation profiles. As proof of concept, applied OncoLoop to prostate genetically engineered...
<p>Detailed Materials and Methods</p>
<p>Detailed Materials and Methods</p>