A5025411463- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Marine and fisheries research
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Colorectal and Anal Carcinomas
- Celiac Disease Research and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Crustacean biology and ecology
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Potassium and Related Disorders
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Coral and Marine Ecosystems Studies
- Eosinophilic Esophagitis
- Fish Ecology and Management Studies
- Gastrointestinal disorders and treatments
- Thyroid Cancer Diagnosis and Treatment
- Radiology practices and education
- Surgical site infection prevention
Yale University
2014-2025
Fisheries and Oceans Canada
2025
Providence Portland Medical Center
2024
Curtin University
2024
Yale New Haven Hospital
2017-2024
Surrey and Sussex Healthcare NHS Trust
2023
Yale Cancer Center
2021-2022
St James's University Hospital
2022
Humber Teaching NHS Foundation Trust
2018
Creative Commons
2018
Definition Subacromial shoulder pain is commonly located to the top and lateral side of shoulder. It exaggerated by overhead activity can be associated with night pain. usually full passive range movement glenohumeral joint. The originates from subacromial space shoulder, an area made up rotator cuff tendons bursa. This separate main Pain this mainly caused tendinopathy, also referred as ‘shoulder impingement’. Impingement occurs between undersurface acromion (roof shoulder) tendons. These...
Immune surveillance in tissues is mediated by a long-lived subset of tissue-resident memory T cells (Trm cells). A putative stem characterized the ability to efflux Hoechst dyes and referred as side population (SP) cells. Here, we have SP (Tsp cells) that exhibit quiescent (G0) phenotype humans mice. Human Trm gut BM were enriched Tsp predominantly G0 stage cell cycle. Moreover, histone 2B-GFP mice, label was retained cells, indicative slow-cycling phenotype. displayed distinct...
Podoplanin, recognized by monoclonal antibody D2-40, may be a useful marker for follicular dendritic cell (FDC) tumors. Paraffin sections of 125 cell, histiocytic, and spindle lesions were studied, including 11 FDC tumors, 5 interdigitating 10 histiocytic sarcomas, Langerhans histiocytosis, sinus histiocytosis with massive lymphadenopathy, inflammatory pseudotumors lymph node or spleen, 9 nodal Kaposi 6 myofibroblastic tumors (IMTs), 29 gastrointestinal stromal (GISTs), cases each malignant...
Colorectal polyps containing S-100–positive neural proliferations in the lamina propria that lack ganglion cells have been variously referred to as "neuromas" or "neurofibromas." However, these lesions not systematically examined, and whether they are associated with type 1 neurofibromatosis (NF1) other inherited syndromes is unknown. The aim of this study was evaluate clinicopathologic immunohistochemical features lesions, comparison colorectal neurofibromas from known NF1 patients....
Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide. Several types chronic liver disease predispose to HCC, and several different signalling pathways have been implicated in its pathogenesis, but no common molecular event has identified. Ca
Abstract Background Sex-related differences in colorectal (CRC) incidence and mortality are well-documented. However, the impact of sex on metabolic pathways that drive cancer growth is not well understood. High expression asparagine synthetase ( ASNS ) associated with inferior survival for female CRC patients only. Here, we used a CRISPR/Cas9 technology to generate HCT116 −/− HCT 116 +/+ cell lines. We examine effects deletion tumor subsequent rewiring male Rag2/IL2RG mice. Results loss...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 376:185-192 (2009) - DOI: https://doi.org/10.3354/meps07803 Distinguishing disease impacts from larval supply effects in a lobster fishery collapse Richard A. Wahle1,*, Mark Gibson2, Michael Fogarty3 1Bigelow Laboratory for Ocean Sciences, West Boothbay Harbor, Maine 04575, USA 2Rhode Island Division of Fish...
Mastocytic enterocolitis is a recently described entity defined by chronic diarrhea of unknown etiology and normal colon biopsy results with increased mast cells (MCs) seen on special stains. These patients may benefit from cell stabilizers; however, the clinical utility MC counts remains unknown.To determine colonic biopsies in etiology.Blinded using c-Kit stain were performed 76 consecutive who had 89 control presenting for screening colonoscopy. Mast counted per single high-power field...
Many mechanisms of and treatments for type 1 diabetes studied in the NOD mouse model have not been replicated human disease models. Thus, field research remains hindered by lack an vivo system which to study development onset autoimmune diabetes. To this end, we characterized a using CD4(+) T cells pulsed with autoantigen-derived peptides. Six weeks after injection as few 0.5 × 10(6) antigen-pulsed into NOD-Scid Il2rg(-/-) expressing HLA-DR4 transgene, infiltration islets was seen. Although...
Abstract Objective Diagnoses rendered using the frozen section (FS) technique during surgical procedures are used to guide intraoperative decisions. Therefore, diagnostic FS errors have potential affect patient safety and quality of care. Diagnostic arise due both technical interpretative factors present a challenge pathology laboratories recognize, document, manage in timely fashion. Thus, there is need monitor discrepancies between permanent diagnoses effectively communicate with clinical...
Simpsonaias ambigua (Salamander Mussel) is a freshwater mussel of the Family Unionidae endemic to North America, and it considered endangered across most its range. This species unique among Unionidae, because uses salamander, Necturus maculosus (Mudpuppy), as larval host rather than fish like all other unionids. The overall goal this study was obtain baseline data on current distribution life history traits S. in Ontario, Canada. These are critical for future recovery efforts protect,...
Studies have shown that sex-related differences in asparagine metabolism are associated with gastrointestinal diseases prognosis. However, the effects of exogenous on incidence and phenotype colorectal cancer (CRC) both men women remain unclear. This study describes relationship between supplementation estradiol secretion which is critical for understanding mechanisms sex-dependent signaling events. We show causes pronounced alteration metabolomics using vivo vitro approaches....
Previous studies have shown that hyperplastic and serrated polyps of the colon show variable degrees gastric intestinal differentiation. MUCs are a class approximately 20 genes encode high-molecular-weight glycoproteins, or mucopolysaccharides, widely expressed in epithelial cells organ specificity. The role MUC carcinogenesis is unknown. One previously published study suggested expression MUC6 specific for sessile adenoma/polyps (SSA/Ps) thus can be used to distinguish these lesions from...
Abstract We present results of an international collaboration to survey American lobster Homarus americanus Milne-Edwards, 1837 nurseries in Atlantic Canada and the northeast United States from 2007 2009 under a standardized protocol involving two sampling methods, diver-based suction passive collectors. surveyed young-of-year older juveniles at 191 sites over 39 areas considerably expanding known depth range geographic limits benthic recruitment. Young-of-year densities were strongly...
It is believed that sessile serrated adenomas/polyps lead to the development of microsatellite unstable cancer via a dysplasia-carcinoma sequence. Little known regarding morphologic and biologic features, outcome with dysplasia, or its specific dysplasia subtypes (intestinal versus serrated). The aims this study were analyze compare clinical, pathologic, characteristics intestinal dysplasia. included 86 patients (50 22 14 mixed dysplasia). clinical pathologic prevalence rate prior,...
Refractory celiac disease (RCD) is a rare condition, usually managed at specialized centers. However, gastroenterologists and pathologists in general practices are often the first to consider diagnosis of RCD patients with persistent symptoms. The distinction between type I II crucial as have shortened life expectancy. requires demonstration abnormal intraepithelial lymphocytes and/or monoclonal T-cell populations duodenal biopsies, typically assessed formalin-fixed paraffin-embedded tissue....