A5065099366- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Helicobacter pylori-related gastroenterology studies
- Aortic aneurysm repair treatments
- Health Systems, Economic Evaluations, Quality of Life
- Infectious Aortic and Vascular Conditions
- Infective Endocarditis Diagnosis and Management
- Peripheral Artery Disease Management
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Atrial Fibrillation Management and Outcomes
- Tracheal and airway disorders
- Advanced MRI Techniques and Applications
- Coronary Artery Anomalies
- Amoebic Infections and Treatments
North Bristol NHS Trust
2010-2025
Pakistan Institute of Nuclear Science and Technology
2021-2025
Southmead Hospital
2008-2025
Jackson Memorial Hospital
2024
King Khalid University
2024
National University of Medical Sciences
2024
University of Mississippi Medical Center
2024
Quaid-i-Azam University
2021-2023
University of Münster
2022-2023
University Hospitals Bristol NHS Foundation Trust
2012-2021
GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns patients newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available. This study sought to describe phase baseline data and compare these pre-NOAC era collected during 1. During 2,...
There are limited data on the impact of successful chronic total occlusion (CTO) revascularization by percutaneous coronary intervention (PCI) survival. We performed a retrospective study comparing survival between patients with and failed CTO PCI.Between January 1, 2000 June 30, 2004, 543 5803 (9.4%) underwent PCI for at our center. A was defined as an artery present least 3 months Thrombolysis in Myocardial Infarction flow grade 0 or 1. Patient records were linked to national database...
Introduction The clinical effectiveness of a ‘rule-out’ acute coronary syndrome (ACS) strategy for emergency department patients with chest pain, incorporating single undetectable high-sensitivity cardiac troponin (hs-cTn) taken at presentation, together non-ischaemic ECG, remains unknown. Methods A randomised controlled trial, across eight hospitals in the UK, aimed to establish an hs-cTn and ECG (limit detection discharge (LoDED)) strategy. Eligible adult presented pain; treating clinician...
Healthcare services worldwide have been significantly impacted by the COVID-19 pandemic. Recent reports shown a decline in hospitalization for emergency cardiac conditions. The impact of pandemic on and particularly mortality due to acute heart failure has not thoroughly described.In this single-centre observational study, we examined referrals team over period 16 weeks (7 January 27 April 2020) spanning ongoing pandemic; 283 patients referred our study were included basis typical symptoms,...
Gastroesophageal reflux disease (GERD) manifests in distinct phenotypes, including erosive (ERD) and nonerosive (NERD), which exhibit differences pathophysiology clinical outcomes. This study aims to explore microbial across these phenotypes. RNA sequencing data of 69 esophageal samples from esophagitis (RE) NERD patients were retrieved NCBI SRA identify key taxa. Alpha beta diversity analyses conducted, DESeq2 Lefse used bacterial biomarkers differentiate ER NERD. Five dominant phyla...
The patency of saphenous vein grafts is poor compared with native and arterial bypass grafts. Graft failures are often managed percutaneous coronary intervention (PCI) because the higher risks undergoing redo artery graft surgery. In addition, PCI to has a high incidence stent failure but still sometimes required, especially in refractory angina similar our case. We demonstrate safety feasibility use intravascular lithotripsy as an adjunct for severe calcified in-stent restenosis graft. Our...
<h3>Objective.</h3> Black Africans currently experience a distinctly low frequency of atherosclerotic cardiovascular disease. Whether this protection persists in those with rheumatoid arthritis (RA) is unknown. We compared the carotid atherosclerosis burden and its relationships (CV) risk factors between RA from developing black developed CV population. <h3>Methods.</h3> performed high resolution B-mode ultrasonography assessed 243 patients established RA, whom 121 were 122 white. Data...
A gastric cancer (GC) diagnosis relies on histopathology. Endoscopy rates are increasing. Helicobacter pylori infection is a major GC risk factor. In an effort to elucidate abundant blood biomarkers, and potentially reduce the number of diagnostic surgical interventions, we investigated sera biopsies from cohort 219 H. positive negative patients diagnosed with GC, gastritis, ulcers. This allowed comparative investigation different gastroduodenal diseases, exclusion protein changes resulting...
Visidex (Ames Company, Elkhart, Indiana) and Accu-Chek bG (Bio-Dynamics, Boehringer Mannheim, Indianapolis, Indiana), two new devices for determining blood glucose at home, were compared with older devices, Chemstrip (Bio-Dynamics) Glucometer Company), the standard laboratory glucose-oxidase method (Beckman autoanalyzer, Beckman Instruments, Fullerton, California). Laboratory serum values up to 400 mg/dl had excellent overall correlation (r = 0.974), 0.963), 0.955). For ≤180 mg/dl, best...
Purpose. A case of toxicity encountered with low-dose methotrexate therapy is discussed. Summary. 59-year-old African American woman receiving long-term for psoriasis came to the hospital painful ulcers, difficulty swallowing, cutaneous lesions, and acute renal failure. Her medical history included type 2 diabetes mellitus, hypertension, coronary artery disease, morbid obesity, psoriasis. On admission, patient looked ill had a low-grade fever; maculopapular skin lesions; bullae vesicles in...
The Royal College of Pathologists Thy1-5 thyroid cytology guidance, 2009, second edition 2016, invites audits its use. This report documents the experience one department, assessing percentage usage each Thy category, correlation with subsequent histology and comparison other published studies.Thyroid reports for 7 years (1 January 2008-31 December 2014) were reviewed, excluding referrals. Years 2008-2010 compared 2011-2014.There 1090 specimens in 2008-2010, 1239 2011-2014....
(1) Background: Gastric cancer (GC) is the fourth leading cause of cancer-related deaths worldwide. Helicobacter pylori infection a major risk factor, but other microbial species may also be involved. In context an earlier proteomics study serum and biopsies patients with gastroduodenal diseases, we explored here simplified microbiome in these (H. pylori, Acinetobacter baumannii, Escherichia coli, Fusobacterium nucleatum, Bacteroides fragilis) on protein level. (2) Methods: A cohort 75 was...
Fourteen insulin-dependent diabetic children reused their disposable syringe-needle units an average of 6.3 times per needle. Between uses, the needle was wiped with alcohol and stored in refrigerator. There were no infections reported during study for duration 94 days. Dullness major reason changing to a new one. Recurrent use needles insulin injections appears safe may be advised. It will help decrease some high cost daily care person diabetes.
(1) Background: Untargeted mass spectrometry (MS)-based proteomic analysis is highly amenable to automation. Software algorithms translate raw spectral data into protein information obtained by a comparison sequence databases. However, the technology has limitations, especially for analytes measured at limit of detection. In expression study human gastric biopsies, question arose whether or not it possible, as well sensible, search viral proteins in addition those from host. (2) Methods:...
Background: Out-of-hospital cardiac arrest (OHCA) is associated with very poor clinical outcomes. An optimal pathway of care yet to be defined, but prognostication likely assist in the challenging decision-making required for treatment this high-risk patient cohort. The MIRACLE2 score provides a simple method neuro-prognostication as it has not been externally validated. aim study was therefore retrospectively apply cohort OHCA patients assess predictive ability and accuracy identification...
Introduction Observational data suggest a single high-sensitivity troponin blood test taken at emergency department (ED) presentation could be used to rule out major adverse cardiac events (MACE) in 10%–60% of ED patients with chest pain. This is done using an ‘undetectable’ cut-off (the Limit Detection: LoD). We combined the LoD ECG findings create LoDED strategy. aim establish whether strategy works under real-life conditions, when compared existing strategies, way that cost-effective and...
Metastatic spread of invasive lobular breast carcinoma to stomach is rare especially before diagnosis primary cancer. Incorrect might result in delay appropriate treatment for Recognition this possibility enables better clinical management. A 62-year-old female presented with upper gastrointestinal symptoms and weight loss was referred a gastroenterologist investigation. At the time initial cancer, patient asymptomatic Multiple gastric biopsies taken showed features suspicious metastatic...
Acute rupture of a thoracic mycotic aneurysm is surgical emergency that requires urgent treatment to prevent further bleeding. The results repair are limited by high mortality and paraplegia rates. Endovascular with stent graft deployment has been reported as an alternative high-risk surgery. We present the case patient ruptured aorta complicated aorto-oesophageal fistula. was successful at controlling Oesophagectomy required for persistent leak from oesophagus. remained stable 13 months...