A5085490974- Blood Pressure and Hypertension Studies
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Cardiovascular Function and Risk Factors
- Nutritional Studies and Diet
- Asthma and respiratory diseases
- Pregnancy and preeclampsia studies
- Cardiovascular Disease and Adiposity
- Trauma Management and Diagnosis
- Cardiovascular and exercise physiology
- Cardiac electrophysiology and arrhythmias
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Renal function and acid-base balance
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Hemodynamic Monitoring and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Rheumatoid Arthritis Research and Therapies
- Chemokine receptors and signaling
Hospital Clínico Universitario Virgen de la Victoria
2024
Instituto de Salud Carlos III
2013-2024
Hospital for Sick Children
2024
Emory University
2024
Brigham and Women's Hospital
2024
Harvard University
2024
Hospital General Universitario De Valencia
2011-2023
Universitat de València
2012-2023
Einstein Medical Center Philadelphia
2017-2023
University of Illinois Chicago
2023
GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns patients newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available. This study sought to describe phase baseline data and compare these pre-NOAC era collected during 1. During 2,...
The aim of the present study was to analyze relationship between insulin resistance and ambulatory blood pressure components in obese children adolescents. Eighty-seven overweight white adolescents both sexes, European origin from 6 18 years age (mean age: 10.9+/-2.7 years), were selected. Obesity defined on basis a threshold body mass index z score >2 (Cole's least mean square method) with 85th 97th percentile. A validated oscillometric method used measure BP (Spacelabs 90207) during 24...
The present prospective study assessed the impact of birth weight (BW) and postnatal gain on blood pressure metabolic profile during first 5 years life. One hundred thirty-nine newborns (63 women) born at term after uncomplicated pregnancies in absence perinatal illness were included. Subjects divided according to size small, appropriate, large for gestational age. After initial evaluation second day life, infants followed up 6 months 2 years. Anthropometric parameters measured each visit...
Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, risk adverse Asian patients with AF, using data from a global prospective cohort study.From GLORIA-AF Registry Phase II-III (November 2011-December 2014 for II, January 2014-December 2016 III), we analysed according their self-reported ethnicity (Asian vs. non-Asian), as well subgroups (Chinese, Japanese,...
Abstract Objective To investigate the possible association of CT60A/G marker with systemic lupus erythematosus (SLE) in Spanish patients, and to identify CTLA4 haplotype responsible for association, taking into account other polymorphisms described at positions −1722T/C, −319C/T, +49A/G, microsatellite (AT) n 3′‐untranslated region (3′‐UTR) gene. Methods Genotyping CT60 was performed 395 patients SLE 293 healthy controls using polymerase chain reaction (PCR)–restriction fragment length...
Objectives Obesity is an increasingly frequent problem among children and adolescents, may lead to blood pressure (BP) increase. The aim of the present study was assess prevalence hypertension, white-coat masked hypertension in obese adolescents making systematic use both office BP 24-h ambulatory measurement. impact different degrees obesity on heart rate variability also investigated. Methods Office were obtained 285 overweight Caucasian (11–18 years old) 180 age- sex-matched controls....
The aim of this study was to assess the impact obesity and low birth weight on both office ambulatory blood pressure (BP) values, as well aortic-derived parameters in youths. A total 422 white youths, from 10 18 years age, were included. Subjects divided into 4 groups according presence (234; 55%) or absence (188; 45%) (114; 27%) normal (308; 73%, weight. Spacelabs 90207 used measure BP during a 24-hour period. SphygmoCor radial/aortic transform software estimate aortic waveform. Office,...
The objective was to assess the differences between 2016 European Society of Hypertension (ESH) and 2017 American Academy Pediatrics (AAP) hypertension (HTN) guidelines in distribution office blood pressure (BP) categories as well ambulatory BP mismatches.The study included 4940 clinical evaluations performed 2957 youth (5-18 years) both sexes. anthropometric parameters were measured following standard conditions. classification measurements normotension, high-normal, stages 1 2 HTN,...
Abstract Background and purpose Prospectively collected data comparing the safety effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods In GLORIA-AF, a large, prospective, global registry program, consecutive AF were followed for 3 years. The comparative analyses (1) dabigatran vs rivaroxaban or apixaban (2) performed on propensity score (PS)-matched patient...
Aim The present research has been undertaken prospectively to study the impact of birthweight and growth pattern on blood pressure changes from birth through first year life. Methods Parents newborns born at term (gestational age > 37 weeks) after uncomplicated pregnancies in absence perinatal illness were randomly invited allow their children participate study. One hundred forty-nine (84 male 65 female) included analysis. divided into four groups according birthweight: < 2500 g (n = 23);...
Abstract Objectives Pulmonary hypertension (PH) is extremely common in acute decompensated heart failure (ADHF) patients and predicts increased mortality. Obstructive sleep apnea (OSA), highly prevalent congestive patients, may contribute to further elevated pulmonary pressures. This study evaluates the impact of positive airway pressure (PAP) therapy on PH admitted for ADHF with OSA. Methods A two-center randomized control trial comparing standard care (SOC) versus addition PAP concomitant...
Background: Bladder cancer (BC) is a prevalent malignancy with muscle-invasive bladder (MIBC) accounting for 20% of cases and poor prognosis 5-year survival ~50%. Although neoadjuvant chemotherapy (NAC) followed by radical cystectomy recognized as the optimal approach treating locally advanced cancer, it important to acknowledge limitations NAC, which include toxicity lack response in certain individuals. There an unmet need predictive assays stratify patients who are likely benefit from...
The possible role of the functional polymorphism located in regulatory region monocyte chemoattractant protein-1 (MCP-1) gene susceptibility to systemic lupus erythematosus (SLE) was investigated. Two hundred and seventy-six SLE patients (among them, 99 with nephritis 55 cutaneous vasculitis) 194 ethnically matched healthy controls were included study. Genotyping for -2518 (A/G) MCP-1 performed by polymerase chain reaction-restriction fragment length (PCR-RFLP) analysis. No association...
The present prospective study assessed the association of birth weight (BW) and growth pattern on cardiometabolic risk factors in a cohort followed from to 10 years age. One hundred forty-five subjects (73 girls) who fulfilled inclusion criteria had all their data recorded at 5 were enrolled. Of these, 100 (52 also years. Anthropometric measurements, office 24-hour blood pressure, metabolic parameters obtained. At years, both BW current determinants pressure parameters; however, as got...
The underuse of oral anticoagulation in patients with nonvalvular atrial fibrillation (AF) is a major issue that not well understood.
Abstract Droplet‐based bioprinting has shown remarkable potential in tissue engineering and regenerative medicine. However, it requires bioinks with low viscosities, which makes challenging to create complex 3D structures spatially pattern them different materials. This study introduces a novel approach sophisticated volumetric objects by merging droplet‐based cryobioprinting techniques. By leveraging the benefits of cryopreservation, we fabricated, for first time, intricate, self‐supporting...
CD8(+) T lymphocytes recognize infected cells that display virus-derived antigenic peptides complexed with major histocompatibility complex class I molecules. Peptides are mainly byproducts of cellular protein turnover by cytosolic proteasomes. Cytosolic tripeptidyl-peptidase II (TPPII) also participates in degradation. Several peptidic epitopes unexpectedly do not require proteasomes, but it is unclear which proteases generate them. We studied antigen processing influenza virus...
The aim of the present study is to assess whether obesity associated with urinary albumin excretion and what main determinants are.One hundred thirty-four obese white children adolescents both sexes, ranging from 9 18 years age (mean 12.6 ± 2.0), were included in study. Obesity was defined on basis a threshold BMI z-score more than 2 (Cole's LMS method) overweight 85th 95th percentile. Office blood pressure measured using mercury sphygmomanometer. Urinary first voiding urine morning...
Lurbe, Empar; Aguilar, Francisco; Gomez, Ana; Tacons, Jose; Alvarez, Vicente; Redon, Josep Author Information
In patients with heart failure preserved ejection fraction (HFpEF), worse kidney function is associated overall cardiac mechanics. Right ventricular stroke work index (RVSWI) a parameter of right function. The aim our study was to determine the relationship between RVSWI and glomerular filtration rate (GFR) in HFpEF.This single-center cross-sectional study. HFpEF defined as documented > 50% pulmonary wedge pressure 15 mm Hg from catheterization. (normal value 8-12 g/m/beat/m2) calculated...
Objectives Some patients with postural orthostatic tachycardia syndrome (POTS) demonstrate improved dysautonomic symptoms following treatment for pelvic venous insufficiency (PVI). This study assessed the prevalence of significant left common iliac vein (LCIV) compression in POTS patients. Methods Radiologists retrospectively reviewed CT images veins 216 women (191 and 25 age-comparable controls).Quantitative vascular analysis identified percent-diameter LCIV by right artery. Significant was...