A5008796502- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Neuroscience and Neural Engineering
- Chemical Synthesis and Analysis
- Pluripotent Stem Cells Research
- RNA and protein synthesis mechanisms
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Surface Modification and Superhydrophobicity
- Monoclonal and Polyclonal Antibodies Research
- Additive Manufacturing and 3D Printing Technologies
Brigham and Women's Hospital
2024-2025
Harvard University
2024-2025
University of Freiburg
2021-2023
Abstract Droplet‐based bioprinting has shown remarkable potential in tissue engineering and regenerative medicine. However, it requires bioinks with low viscosities, which makes challenging to create complex 3D structures spatially pattern them different materials. This study introduces a novel approach sophisticated volumetric objects by merging droplet‐based cryobioprinting techniques. By leveraging the benefits of cryopreservation, we fabricated, for first time, intricate, self‐supporting...
Electrical stimulation of existing three-dimensional bioprinted tissues to alter tissue activities is typically associated with wired delivery, invasive electrode placement, and potential cell damage, minimizing its efficacy in cardiac modulation. Here, we report an optoelectronically active scaffold based on printed gelatin methacryloyl embedded micro-solar cells, seeded cardiomyocytes form light-stimulable tissues. This enables untethered, noninvasive, damage-free optoelectronic...
Spheroids, organoids, or cell-laden droplets are often used as building blocks for bioprinting, but so far little is known about the spatio-temporal cellular interactions subsequent to printing. We a drop-on-demand bioprinting approach study biological of such in dimensions micrometers. Highly-density (approximately 700 cells 10 nL) multiple cell types were patterned 3D hydrogel matrix with precision up 70 μm. The patterns investigate endothelial (HUVECs) and adipose-derived mesenchymal stem...
In the rapidly expanding field of peptide therapeutics, short in vivo half-life peptides represents a considerable limitation for drug action. D-peptides, consisting entirely dextrorotatory enantiomers naturally occurring levorotatory amino acids (AAs), do not suffer from these shortcomings as they are intrinsically resistant to proteolytic degradation, resulting favourable pharmacokinetic profile. To experimentally identify D-peptide binders interesting therapeutic targets, so-called...
Abstract Spheroids, organoids, or highly-dense cell-laden droplets are often used as building blocks for bioprinting, but so far little is known about the spatio-temporal cellular interactions post printing. We present a drop-on-demand approach to study biological of such in micrometer dimensions. Droplets (containing approximately 700 cells 10 nl) multiple cell types patterned 3D hydrogel matrix with precision less than 70 μm. It applied investigate relevant vascularization approaches. show...