A5055061011- Immunodeficiency and Autoimmune Disorders
- Muscle metabolism and nutrition
- Cancer, Lipids, and Metabolism
- Genetics and Physical Performance
- Peptidase Inhibition and Analysis
- Physical Activity and Health
- Adipose Tissue and Metabolism
- Eating Disorders and Behaviors
- Immune Cell Function and Interaction
- High Altitude and Hypoxia
- Virology and Viral Diseases
- Sports Performance and Training
- Cytomegalovirus and herpesvirus research
- Cancer, Hypoxia, and Metabolism
- Diabetes and associated disorders
- RNA and protein synthesis mechanisms
- Hematopoietic Stem Cell Transplantation
- Virus-based gene therapy research
- Complement system in diseases
- RNA modifications and cancer
- Obesity, Physical Activity, Diet
- Signaling Pathways in Disease
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- Acute Myeloid Leukemia Research
Technical University of Munich
2022-2025
University of Freiburg
2021-2024
Rockefeller University
2024
Institute of Medical Microbiology and Hygiene
2024
University Medical Center Freiburg
2024
Leukemia relapse is a major cause of death after allogeneic hematopoietic cell transplantation (allo-HCT). We tested the potential targeting TIM-3 for improving graft-versus-leukemia (GVL) effects. observed differential expression ligands when stem cells overexpressed certain oncogenic-driver mutations. Anti-TIM-3 Ab-treatment improved survival mice bearing leukemia with oncogene-induced ligand expression. Conversely, low were anti-TIM-3 treatment-resistant. In vitro, blockade or genetic...
Cancer cells, immune and stromal cells within the tumor microenvironment (TME) collaboratively influence disease progression therapeutic responses. The nutrient-limited conditions of TME, particularly scarcity glucose, amino acids, lipids, challenge cancer cell survival. However, metabolic constraints faced by in comparison to how these limitations affect outcomes, remain poorly understood. Here, we introduce Dual Ribosome Profiling (DualRP), a method that allows for simultaneous analysis...
ABSTRACT Purpose The purpose was to evaluate the individual and combined use of Low Energy Availability in Females Questionnaire (LEAF-Q) Brief Eating Disorder Athletes (BEDA-Q) detect clinical indicators associated with Relative Deficiency Sport (REDs). Methods In this cross-sectional study, 50 female endurance athletes training ≥4x/week completed LEAF-Q BEDA-Q were assessed for presence selected REDs indicators. meeting criteria mild or more severe severity/risk according International...
SYNTAXIN-11 (STX11) is a SNARE protein that mediates the fusion of cytotoxic granules with plasma membrane at immunological synapses CD8 T or NK cells. Autosomal recessive inheritance deleterious STX11 variants impairs granule exocytosis, causing familial hemophagocytic lymphohistiocytosis type 4 (FHL-4). In several FHL-4 patients, we also observed hypogammaglobulinemia, elevated frequencies naive B cells, and increased double-negative DN2:DN1 cell ratios, indicating hitherto unrecognized...
In the rapidly expanding field of peptide therapeutics, short in vivo half-life peptides represents a considerable limitation for drug action. D-peptides, consisting entirely dextrorotatory enantiomers naturally occurring levorotatory amino acids (AAs), do not suffer from these shortcomings as they are intrinsically resistant to proteolytic degradation, resulting favourable pharmacokinetic profile. To experimentally identify D-peptide binders interesting therapeutic targets, so-called...
Alpine skiing is characterized by phases of demanding on-snow glacier training and competitions in extreme environments, where maintaining body composition (BC) crucial for performance may play a role injury prevention. However, sport-specific literature on energy balance (EB) strategies to avoid unfavorable changes BC are still lacking. PURPOSE: To analyze EB during camp at altitude over the course competitive season. METHODS: In prospective observational study, active male (n = 9, 27 ± 2.9...
The competitive season in long-distance triathlon is characterized by increases training load and volume from off- to peak-season, when athletes enter their primary competition. When fail meet the increased energy demand through diet, either unintentionally or attempts improve performance means of weight loss, they are at an risk for low availability (LEA), which can negatively impact health performance. PURPOSE: To analyze changes body composition over course investigate indicators LEA...