A5013555825- interferon and immune responses
- HIV Research and Treatment
- Inflammasome and immune disorders
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- HIV/AIDS drug development and treatment
- Acute Myeloid Leukemia Research
- Vascular Anomalies and Treatments
- Hydrogels: synthesis, properties, applications
- Ocular Diseases and Behçet’s Syndrome
- NF-κB Signaling Pathways
- Kawasaki Disease and Coronary Complications
- Streptococcal Infections and Treatments
- Silk-based biomaterials and applications
- Immune Response and Inflammation
- Hematopoietic Stem Cell Transplantation
- Otitis Media and Relapsing Polychondritis
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- Electrospun Nanofibers in Biomedical Applications
- Endoplasmic Reticulum Stress and Disease
University of Freiburg
2021-2022
University Medical Center Freiburg
2021
Seoul National University
1995-2021
Human SAMHD1 possesses dual enzymatic functions. It acts as both a dGTP-dependent triphosphohydrolase and an exoribonuclease. The dNTPase function depletes the cellular dNTP pool, which is required for retroviral reverse transcription in differentiated myeloid cells resting CD4(+) T cells; thus this activity mainly plays role SAMHD1-mediated restriction. However, recent study demonstrated that directly targets HIV-1 genomic RNA via its RNase activity, (rather than activity) sufficient While...
The comorbid association of autoimmune diseases with cancers has been a major obstacle to successful anti-cancer treatment. Cancer survival rate decreases significantly in patients preexisting autoimmunity. However, date, the molecular and cellular profiles such comorbidities are poorly understood. We used Aicardi-Goutières syndrome (AGS) as model disease explored underlying mechanisms genome instability AGS-associated-gene-deficient patient cells. found that R-loops highly enriched at...
PURPOSE: To evaluate the radiographic and computed tomographic (CT) findings of patients with thoracic Behçet syndrome. MATERIALS AND METHODS: Chest radiographs CT scans nine syndrome were retrospectively reviewed. Findings compared. RESULTS: Radiographs showed mediastinal widening in five (56%), air-space consolidation lung mass three (33%). that was due to thrombosis four (44%) or narrowing superior vena cava one [11%], which caused edema; (seen on both scans) pulmonary hemorrhage...
The autoimmune disorder Aicardi-Goutières syndrome (AGS) is characterized by a constitutive type I interferon response. SAMHD1 possesses both dNTPase and RNase activities mutations in cause AGS; however, how SAMHD1-deficiency causes the response patients with AGS remains unknown. Here, we show that endogenous RNA substrates accumulated absence of act as major immunogenic source for Reconstitution SAMHD1-negative human cells wild-type but not RNase-defective abolishes spontaneous induction....
Abstract Innate immune sensing of cytosolic DNA via absent in melanoma 2 (AIM2) is a key mechanism leading to inflammatory responses. As aberrant responses by dysregulated AIM2 are associated with autoinflammatory diseases, activation the inflammasome should be tightly controlled. In this study, we discovered that ubiquitination and deubiquitination critical events regulate activation. resting human macrophage cells, constitutively ubiquitinated undergoes proteasomal degradation avoid...
Most antigenic peptides are generated by proteasomes in the cytosol and transported transporter associated with antigen processing (TAP) into endoplasmic reticulum, where they bind nascent major histocompatibilitiy complex class I molecule (MHC-I). Although overall process of peptide-MHC-I assembly is well studied, mechanism which free delivered from TAP to MHC-I unknown. In this study, we investigated possible role protein disulfide isomerase (PDI) as a peptide carrier between MHC-I....
Major histocompatibility complex class I (MHC-I) molecules bind antigens in the endoplasmic reticulum (ER) and deliver them to cell surface for immune surveillance of viruses tumors. Whereas key steps MHC-I assembly its acquisition peptides ER are relatively well defined, little is known about how leave expression. Here, we show that export human classical (HLA-A/-B/-C) regulated by their C-terminal single amino acid, valine or alanine. These acids, conserved nearly all alleles, serve as...