A5065720202- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- Neuroscience and Neural Engineering
- Advanced Sensor and Energy Harvesting Materials
- 3D Printing in Biomedical Research
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Congenital Heart Disease Studies
- Tracheal and airway disorders
- Heart Failure Treatment and Management
- Infectious Aortic and Vascular Conditions
- Cardiac pacing and defibrillation studies
- Vascular Procedures and Complications
- Transplantation: Methods and Outcomes
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Pericarditis and Cardiac Tamponade
- Cardiac Arrhythmias and Treatments
- Animal testing and alternatives
- Radiation Dose and Imaging
Houston Institute for Clinical Research
2025
Jesse Brown VA Medical Center
2024
University of Illinois Chicago
2024
St. Luke's Medical Center
2019
Nagasaki University
2018-2019
California Institute for Regenerative Medicine
2018
Tanta University
2018
Currently, most of the artificial airway organs still require scaffolds; however, such scaffolds exhibit several limitations. Alternatively, use an autologous trachea without foreign materials and immunosuppressants may solve these issues constitute a preferred tool. The rationale this study was to develop new scaffold-free approach for using bio-3D printing technology. Here, we assessed circumferential tracheal replacement trachea-like grafts generated from isolated cells in inbred animal...
Heart rate variability (HRV) is a measurement of the fluctuation time between each heartbeat and reflects function autonomic nervous system. HRV an important indicator for both physical mental status broad-scope diseases. In this review, we discuss how wearable devices can be used to monitor HRV, compare monitoring among different devices. addition, have reviewed recent progress in tracking with its value health disease diagnosis. Although many challenges remain, believe promising tool that...
Various strategies have been attempted to replace esophageal defects with natural or artificial substitutes using tissue engineering. However, these methods not yet reached clinical application because of the high risks related their immunogenicity insufficient biocompatibility. In this study, we developed a scaffold-free structure mixture cell types bio-three-dimensional (3D) printing technology and assessed its characteristics in vitro vivo after transplantation into rats. Normal human...
Abstract The need to develop wearable devices for personal health monitoring, diagnostics, and therapy has inspired the production of innovative on‐demand, customizable technologies. Several these technologies enable printing raw electronic materials directly onto biological organs tissues. However, few them have been thoroughly investigated biocompatibility on cellular, tissue, organ levels or with different cell types. In addition, highly accurate multiday in vivo monitoring using such...
Electrical stimulation of existing three-dimensional bioprinted tissues to alter tissue activities is typically associated with wired delivery, invasive electrode placement, and potential cell damage, minimizing its efficacy in cardiac modulation. Here, we report an optoelectronically active scaffold based on printed gelatin methacryloyl embedded micro-solar cells, seeded cardiomyocytes form light-stimulable tissues. This enables untethered, noninvasive, damage-free optoelectronic...
Engineering a bioartificial heart has become possibility in part because of the regenerative medicine approaches to repairing or replacing damaged organs that have evolved over past two decades. With advent inducible pluripotent stem cell technology, it is now possible generate personalized cells make concept autologous tissue engineering imaginable. Scaffolds provide form, function, and biological cues likewise potentially enable biocompatible vascularized solid organs. Decellularized...
Background: Impaired myocardial conduction is the underlying mechanism for re-entrant arrhythmias. Carbon nanotube fibers (CNTfs) combine mechanical properties of suture materials with conductive metals and may form a restorative solution to impaired conduction. Methods: Acute open chest electrophysiology studies were performed in sheep (n=3). Radiofrequency ablation was used create epicardial delay after which CNTf then silk controls applied. CNTfs surgically sewn across right...
Heart rate variability (HRV) is a measurement of the fluctuation time between each heartbeat and reflects function autonomic nervous system. HRV an important indicator for both physical mental status broad-scope diseases. In this review, we discuss how wearable devices can be used to monitor HRV, compare monitoring among different devices. addition, have reviewed recent progress in tracking with its value health disease diagnosis. Although many challenges remain, believe promising tool that...
The ultimate solution for patients with end-stage heart failure is organ transplant. But donor hearts are limited, immunosuppression required, and ultimately rejection can occur. Creating a functional, autologous bio-artificial could solve these challenges. Biofabrication of comprised scaffold cells one option. A natural tissue-specific composition as well micro- macro-architecture be obtained by decellularizing from humans or large animals such pigs. Decellularization involves washing out...
In patients with heart failure, the evaluation of left ventricular (LV) diastolic function is vital, offering crucial insights into hemodynamic impact and prognostic accuracy. Echocardiography stands as primary imaging modality for assessment, using it effectively requires a profound understanding underlying pathology. This review covers four main topics: first, fundamental driving forces behind each phase normal dynamics, along physiological basis two widely used echocardiographic...
In patients with heart failure, the evaluation of left ventricular (LV) diastolic function is vital, offering crucial insights into hemodynamic impact and prognostic accuracy. Echocardiography stands as primary imaging modality for assessment, using it effectively requires a profound understanding underlying pathology. This review covers four main topics: first, fundamental driving forces behind each phase normal dynamics, along physiological basis two widely used echocardiographic...
Left ventricular assist devices (LVADs) are used to treat patients with severe (New York Heart Association class IV) heart failure. Thrombosis and bleeding LVAD-related complications; thus, an effective anticoagulation regimen is crucial for successful postoperative management. The CH-VAD™ (CH Biomedical, Inc.) a small, implantable, full-support (>5 L/min) LVAD centrifugal flow pump that has fully magnetically levitated rotor, which confers superior hemocompatibility. In this study, the was...
Left ventricular assist devices (LVADs) have increasingly been used clinically to treat heart failure patients. However, hemolysis, pump thrombosis, infection and bleeding still persist as major limitations of LVAD technology. Assessing hemocompatibility using a blood shear stress device (BSSD) has clear advantages, the BSSD could provide better experimental platform develop reliable, quantifiable trauma assays perform iterative testing designs. In this study, was proposed with short...