A5030705558- Neuroscience and Neural Engineering
- MXene and MAX Phase Materials
- Advanced Memory and Neural Computing
- EEG and Brain-Computer Interfaces
- Advanced Sensor and Energy Harvesting Materials
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neurological disorders and treatments
- Graphene and Nanomaterials Applications
- Mechanical Circulatory Support Devices
- Epilepsy research and treatment
- Conducting polymers and applications
- Neuroscience and Neuropharmacology Research
- Tissue Engineering and Regenerative Medicine
- Advanced biosensing and bioanalysis techniques
- Lipid Membrane Structure and Behavior
- Electrospun Nanofibers in Biomedical Applications
- Molecular Communication and Nanonetworks
- Neural Networks and Applications
- Neural and Behavioral Psychology Studies
- Electrochemical sensors and biosensors
- Blood properties and coagulation
- Nanoplatforms for cancer theranostics
- Functional Brain Connectivity Studies
- Ferroelectric and Negative Capacitance Devices
Philadelphia VA Medical Center
2018-2025
University of Pennsylvania
2016-2025
California University of Pennsylvania
2018-2024
Translational Therapeutics (United States)
2024
UCLouvain
2023-2024
Veterans Health Administration
2020-2023
Rice University
2013-2021
Hospital of the University of Pennsylvania
2018
Sapienza University of Rome
2010-2013
University of Naples Federico II
2003
The development of microelectrodes capable safely stimulating and recording neural activity is a critical step in the design many prosthetic devices, brain-machine interfaces, therapies for neurologic or nervous-system-mediated disorders. Metal electrodes are inadequate prospects miniaturization needed to attain neuronal-scale stimulation because their poor electrochemical properties, high stiffness, propensity fail due bending fatigue. Here we demonstrate using carbon nanotube (CNT) fiber...
High-resolution neural interfaces are essential tools for studying and modulating circuits underlying brain function disease. Because electrodes miniaturized to achieve higher spatial resolution channel count, maintaining low impedance high signal quality becomes a significant challenge. Nanostructured materials can address this challenge because they combine electrical conductivity with mechanical flexibility interact biological systems on molecular scale. Unfortunately, fabricating...
The major limitation of current engineered myocardial patches for the repair heart defects is that insulating polymeric scaffold walls hinder transfer electrical signals between cardiomyocytes. This loss in signal transduction results arrhythmias when scaffolds are implanted. We report small, subtoxic concentrations single-walled carbon nanotubes, on order tens parts per million, incorporated a gelatin-chitosan hydrogel act as nanobridges cardiomyocytes, resulting enhanced coupling,...
A scalable neural interface technology projected to last at least 6 years in the body samples over a thousand brain sites using flexible electronics.
Soft bioelectronic interfaces for mapping and modulating excitable networks at high resolution large scale can enable paradigm-shifting diagnostics, monitoring, treatment strategies. Yet, current technologies largely rely on materials fabrication schemes that are expensive, do not scale, critically limit the maximum attainable coverage. Solution processing is a cost-effective manufacturing alternative, but biocompatible conductive inks matching performance of conventional metals lacking....
Soft and conductive nanomaterials like carbon nanotubes, graphene, nanowire scaffolds have expanded the family of ultraflexible microelectrodes that can bend flex with natural movement brain, reduce inflammatory response, improve stability long-term neural recordings. However, current methods to implant these highly flexible electrodes rely on temporary stiffening agents temporarily increase electrode size stiffness thus aggravating damage during implantation, which lead cell loss glial...
The chemistry that governs the dissolution of device-grade, monocrystalline silicon nanomembranes into benign end products by hydrolysis serves as foundation for fully eco/biodegradable classes high-performance electronics. This paper examines these processes in aqueous solutions with chemical compositions relevant to groundwater and biofluids. results show presence Si(OH)4 proteins can slow rates ion-specific effects associated Ca2+ significantly increase rates. information allows effective...
Abstract Implantable deep brain stimulation (DBS) systems are utilized for clinical treatment of diseases such as Parkinson’s disease and chronic pain. However, long-term efficacy DBS is limited, neuroplastic changes associated therapeutic mechanisms not well understood. Fundamental mechanistic investigation, typically accomplished in small animal models, difficult because the need stimulators that currently require either frequent handling test subjects to charge battery-powered or...
Very little is known about the atherosclerotic risk in patients with childhood-onset growth hormone deficiency (GHD). Such data may be relevant to reconstructing natural course of cardiovascular abnormalities associated GHD. To this end, intima-media thickness (IMT) carotid arteries and vascular factors were evaluated 14 GHD (age 25 +/- 1 yr, BMI 22 0.6 Kg/m2) age-, sex-, BMI-matched control subjects. IMT was greater (0.83 0.06 0.81 mmol/L for right left artery) than controls (0.64 0.03 0.64...
In NIH3T3 cells, 0.001 nM of the synthetic androgen R1881 induces and stimulates association receptor (AR) with Src phosphatidylinositol 3-kinase (Pl3-kinase), respectively, thereby triggering S-phase entry. 10 Rac activity membrane ruffling in absence receptor–Src–PI3-kinase complex assembly. The antiandrogen Casodex specific inhibitors PI3-kinase prevent both hormonal effects, DNA synthesis cytoskeletal changes. Neither low nor high concentration allows nuclear translocation...
Objective. Implanting subdural and penetrating electrodes in the brain causes acute trauma inflammation that affect intracranial electroencephalographic (iEEG) recordings. This behavior its potential impact on clinical decision-making algorithms for implanted devices have not been assessed detail. In this study we aim to characterize temporal spatial variability of continuous, prolonged human iEEG Approach. Intracranial electroencephalography from 15 patients with drug-refractory epilepsy,...
Understanding cellular electrical communications in both health and disease necessitates precise subcellular electrophysiological modulation. Nanomaterial-assisted photothermal stimulation was demonstrated to modulate activity with high spatiotemporal resolution. Ideal candidates for such an application are expected have absorbance at the near-infrared window, conversion efficiency, straightforward scale-up of production allow future translation. Here, we demonstrate two-dimensional Ti3C2Tx...
Smart wearable electronic accessories (e.g., watches) have found wide adoption; conversely, progress in textiles has been slow due to the difficulty of embedding rigid materials into flexible fabrics. Electronic clothing requires fibers that are conductive, robust, biocompatible, and can be produced on a large scale. Here, we create sewable electrodes signal transmission wires from neat carbon nanotube threads (CNTT). These soft like standard sewing thread, but they metal-level conductivity...
Neurophotonics was launched in 2014 coinciding with the launch of BRAIN Initiative focused on development technologies for advancement neuroscience. For last seven years, Neurophotonics' agenda has been well aligned this focus neurotechnologies featuring new optical methods and tools applicable to brain studies. While 2.0 is pivoting towards applications these novel quest understand brain, article we review an extensive diverse toolkit explore function that have emerged from related...
Flexible fiber-based microelectrodes allow safe and chronic investigation modulation of electrically active cells tissues. Compared to planar electrodes, they enhance targeting precision while minimizing side effects from the device-tissue mechanical mismatch. However, current manufacturing methods face scalability, reproducibility, handling challenges, hindering large-scale deployment. Furthermore, only a few designs can record electrical biochemical signals necessary for understanding...
Objective. The vision of bioelectronic medicine is to treat disease by modulating the signaling visceral nerves near various end organs. In small animal models, interest can have diameters and limited surgical access. New high-resolution methods for building nerve interfaces are desirable. this study, we present a novel interface demonstrate its use stimulation recording in nerves. Approach. We design fabricate micro-scale electrode-laden nanoclips capable interfacing with as 50 µm diameter....
Abstract Wearable sensors for surface electromyography (EMG) are composed of single‐ to few‐channel large‐area contacts, which exhibit high interfacial impedance and require conductive gels or adhesives record high‐fidelity signals. These devices also limited in their ability activation across large muscle groups due poor spatial coverage. To address these challenges, a novel high‐density EMG array is developed based on titanium carbide (Ti 3 C 2 T x ) MXene encapsulated parylene‐C. Ti 2D...
Advanced Healthcare MaterialsVolume 14, Issue 4 2570021 Inside Front CoverFree Access Transparent MXene Microelectrode Arrays for Multimodal Mapping of Neural Dynamics (Adv. Mater. 4/2025) Sneha Shankar, ShankarSearch more papers by this authorYuzhang Chen, Yuzhang ChenSearch authorSpencer Averbeck, Spencer AverbeckSearch authorQuincy Hendricks, Quincy HendricksSearch authorBrendan Murphy, Brendan MurphySearch authorBenjamin Ferleger, Benjamin FerlegerSearch authorNicolette Driscoll,...